Swiss-Prot entry

ID   NR1I3_RAT      STANDARD;      PRT;   358 AA.
AC   Q9QUS1;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Orphan nuclear receptor NR1I3 (Constitutive androstane receptor)
DE   (CAR).
GN   Name=Nr1i3; Synonyms=Car;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fischer, and Wistar Kyoto; TISSUE=Liver;
RX   MEDLINE=21106302; PubMed=11160864 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Yoshinari K., Sueyoshi T., Moore R., Negishi M.;
RT   "Nuclear receptor CAR as a regulatory factor for the sexually
RT   dimorphic induction of CYB2B1 gene by phenobarbital in rat livers.";
RL   Mol. Pharmacol. 59:278-284(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wistar; TISSUE=Liver;
RA   Kanno Y., Aoki S., Nakahama T., Inouye Y.;
RT   "Role of the defective splicing of mRNA in the lack of pulmonary
RT   expression of constitutively active receptor in rat.";
RL   J. Health Sci. 49:541-546(2003).
CC   -!- FUNCTION: Binds and transactivates the retinoic acid response
CC       elements that control expression of the retinoic acid receptor
CC       beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the
CC       phenobarbital responsive element module of the human CYP2B6 gene
CC       and the CYP3A4 xenobiotic response element (By similarity).
CC   -!- SUBUNIT: Heterodimer of NR1I3 and RXR (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- DOMAIN: Composed by a short N-terminal domain followed by the DNA
CC       binding, hinge, and ligand binding/dimerization domains.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; AF133095; AAF22567.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF133094; AAF22566.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AB104736; BAC82431.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AB105071; BAC84955.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P11473; 1KB2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q9QUS1; 117-358.
DR   TRANSFAC; T05312; -.
DR   Ensembl; ENSRNOG00000003260; Rattus_norvegicus
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; Q9QUS1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9QUS1.
DR   ProtoNet; Q9QUS1.
DR   ProtoMap; Q9QUS1.
DR   PRESAGE; Q9QUS1.
DR   DIP; Q9QUS1.
DR   ModBase; Q9QUS1.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     18     93       Nuclear receptor-type.
FT   ZN_FING      21     41       C4-type.
FT   ZN_FING      57     81       C4-type.
SQ   SEQUENCE   358 AA;  40923 MW;  13691F49CAD8F1ED CRC64;
     MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS KTIGPICPFA
     GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR RARQARRRAQ KASLQLSQQQ
     KELIQTLLGA HTRHVGPMFD QFVQFRPPAY LFSHHRPFQP LAPVLPLLTH FADINTFMVQ
     QIIKFTKDLP LFRSLTMEDQ ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV
     HVGFQYEFLE LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL
     ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM PLLGEICS
//