Swiss-Prot entry

ID   NR1I3_MOUSE    STANDARD;      PRT;   358 AA.
AC   O35627; O35628;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Orphan nuclear receptor NR1I3 (Constitutive androstane receptor)
DE   (CAR).
GN   Name=Nr1i3; Synonyms=Car;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORMS CAR1 AND CAR2).
RC   TISSUE=Liver;
RX   MEDLINE=97442417; PubMed=9295294 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1074/jbc.272.38.23565;
RA   Choi H.-S., Chung M., Tzameli I., Simha D., Lee Y.-K., Seol W.,
RA   Moore D.D.;
RT   "Differential transactivation by two isoforms of the orphan nuclear
RT   hormone receptor CAR.";
RL   J. Biol. Chem. 272:23565-23571(1997).
RN   [2]
RP   FUNCTION.
RX   MEDLINE=99393281; PubMed=10462436 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1006/abbi.1999.1351;
RA   Waxman D.J.;
RT   "P450 gene induction by structurally diverse xenochemicals: central
RT   role of nuclear receptors CAR, PXR, and PPAR.";
RL   Arch. Biochem. Biophys. 369:11-23(1999).
CC   -!- SUBUNIT: Heterodimer of NR1I3 and RXR.
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=CAR1;
CC         IsoId=O35627-1; Sequence=Displayed;
CC       Name=CAR2;
CC         IsoId=O35627-2; Sequence=VSP_003671, VSP_003672;
CC         Note=Does not seem to act as a transactivator. Lacks the
CC         C-terminal portion of the ligand binding/dimerization domain;
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in liver.
CC   -!- DOMAIN: Composed by a short N-terminal domain followed by the DNA
CC       binding, hinge, and ligand binding/dimerization domains.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF009327; AAC53349.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; AF009328; AAC53350.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P11473; 1KB2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O35627; 117-358.
DR   TRANSFAC; T02755; -.
DR   Ensembl; ENSMUSG00000005677; Mus_musculus
DR   MGD; MGI:1346307; Nr1i3.
DR   GeneLynx; Nr1i3..
DR   SOURCE; Nr1i3..
DR   GO; GO:0005829; C:cytosol; IDA.
DR   GO; GO:0005634; C:nucleus; IDA.
DR   GO; GO:0005515; F:protein binding; IPI.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; O35627.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O35627.
DR   ProtoNet; O35627.
DR   ProtoMap; O35627.
DR   PRESAGE; O35627.
DR   DIP; O35627.
DR   ModBase; O35627.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Activator; Alternative splicing; DNA-binding; Nuclear protein;
KW   Receptor; Transcription; Transcription regulation; Zinc-finger.
FT   DNA_BIND     18     93       Nuclear receptor-type.
FT   ZN_FING      21     41       C4-type.
FT   ZN_FING      57     81       C4-type.
FT   VARSPLIC    281    286       DRPGVT -> GFCMQS (in isoform CAR2).
FT                                /FTId=VSP_003671.
FT   VARSPLIC    287    358       Missing (in isoform CAR2).
FT                                /FTId=VSP_003672.
SQ   SEQUENCE   358 AA;  40895 MW;  4F07730FF78CADBC CRC64;
     MTAMLTLETM ASEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS KTIGPICPFA
     GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR RARQAQRRAE KASLQLNQQQ
     KELVQILLGA HTRHVGPLFD QFVQFKPPAY LFMHHRPFQP RGPVLPLLTH FADINTFMVQ
     QIIKFTKDLP LFRSLTMEDQ ISLLKGAAVE ILHISLNTTF CLQTENFFCG PLCYKMEDAV
     HAGFQYEFLE SILHFHKNLK GLHLQEPEYV LMAATALFSP DRPGVTQREE IDQLQEEMAL
     ILNNHIMEQQ SRLQSRFLYA KLMGLLADLR SINNAYSYEL QRLEELSAMT PLLGEICS
//