Swiss-Prot entry

ID   NR1H2_RAT      STANDARD;      PRT;   446 AA.
AC   Q62755; Q62694;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan
DE   receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (UR)
DE   (Orphan nuclear receptor OR-1).
GN   Name=Nr1h2; Synonyms=Lxrb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   MEDLINE=95199298; PubMed=7892230 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Teboul M., Enmark E., Li Q., Wikstrom A.C., Pelto-Huikko M.,
RA   Gustafsson J.-A.;
RT   "OR-1, a member of the nuclear receptor superfamily that interacts
RT   with the 9-cis-retinoic acid receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley; TISSUE=Vagina;
RX   MEDLINE=95062154; PubMed=7971966 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Song C., Kokontis J.M., Hiipakka R.A., Liao S.;
RT   "Ubiquitous receptor: a receptor that modulates gene activation by
RT   retinoic acid and thyroid hormone receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994).
CC   -!- FUNCTION: Orphan receptor. Binds preferentially to double-stranded
CC       oligonucleotide direct repeats having the consensus half-site
CC       sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).
CC   -!- SUBUNIT: Forms a heterodimer with RXR.
CC   -!- SUBCELLULAR LOCATION: Nuclear (Potential).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U20389; AAA69522.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; U14533; AAA52361.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; I59354; I59354.
DR   HSSP; P55055; 1P8D. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q62755; 205-445.
DR   TRANSFAC; T04451; -.
DR   Ensembl; ENSRNOG00000019812; Rattus_norvegicus
DR   RGD; 61906; Nr1h2.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; Q62755.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q62755.
DR   ProtoNet; Q62755.
DR   ProtoMap; Q62755.
DR   PRESAGE; Q62755.
DR   DIP; Q62755.
DR   ModBase; Q62755.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     75    152       Nuclear receptor-type.
FT   ZN_FING      78     98       C4-type.
FT   ZN_FING     116    140       C4-type.
FT   DOMAIN      216    446       Ligand-binding (Potential).
FT   DOMAIN      162    168       Poly-Gln.
FT   DOMAIN      169    172       Poly-Pro.
FT   CONFLICT     33     33       G -> V (in Ref. 2).
FT   CONFLICT     52     54       Missing (in Ref. 2).
FT   CONFLICT    219    219       A -> V (in Ref. 2).
SQ   SEQUENCE   446 AA;  49736 MW;  13DF6DC2F0F5FA4D CRC64;
     MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI VVILEPEDEP
     ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVHGG AGRYACRGSG
     TCQMDAFMRR KCQLCRLRKC KEAGMREQCV LSEEQIRKKK IQKQQQQQPP PPTEPASGSS
     ARPAASPGTS EASSQGSGEG EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG
     ADPQSRDARQ QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
     TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL DDAEYALLIA
     INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ LRFPRMLMKL VSLRTLSSVH
     SEQVFALRLQ DKKLPPLLSE IWDVHE
//