Swiss-Prot entry
ID NR1D2_RAT STANDARD; PRT; 578 AA.
AC Q63504; Q62756; Q63542;
DT 15-JUL-1999 (Rel. 38, Created)
DT 15-JUL-1999 (Rel. 38, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR4).
GN Name=Nr1d2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX MEDLINE=96340938; PubMed=8747539 [NCBI, ExPASy, EBI, Israel, Japan];
RA Giambiagi N., Cassia R., Petropoulos I., Part D., Cereghini S.,
RA Zakin M.M., Ochoa A.;
RT "Rev-erb beta 2, a novel isoform of the Rev-erb family of orphan
RT nuclear receptors.";
RL Biochem. Mol. Biol. Int. 37:1091-1102(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 46-578.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX MEDLINE=95032132; PubMed=7945391 [NCBI, ExPASy, EBI, Israel, Japan];
RA Enmark E., Kainu T., Pelto-Huikko M., Gustafsson J.-A.;
RT "Identification of a novel member of the nuclear receptor superfamily
RT which is closely related to Rev-ErbA.";
RL Biochem. Biophys. Res. Commun. 204:49-56(1994).
CC -!- FUNCTION: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-
CC ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR
CC alpha function.
CC -!- SUBUNIT: Interacts with NCOA5 coactivator, leading to a strong
CC increase of transcription of target genes (By similarity).
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Rev-erb-beta-1;
CC IsoId=Q63504-1; Sequence=Displayed;
CC Name=Rev-erb-beta-2;
CC IsoId=Q63504-2; Sequence=VSP_003650, VSP_003651;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; X82777; CAA58021.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X78135; CAA55014.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U20796; AAA62508.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S52913; S52913.
DR HSSP; P20393; 1A6Y. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; Q63504; 98-181.
DR RGD; 628828; Nr1d2.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; Q63504.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q63504.
DR ProtoNet; Q63504.
DR ProtoMap; Q63504.
DR PRESAGE; Q63504.
DR DIP; Q63504.
DR ModBase; Q63504.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; DNA-binding; Nuclear protein; Receptor;
KW Repressor; Transcription; Transcription regulation; Zinc-finger.
FT DOMAIN 13 20 Poly-Ser.
FT DOMAIN 35 39 Poly-Ser.
FT DNA_BIND 100 176 Nuclear receptor-type.
FT ZN_FING 103 123 C4-type.
FT ZN_FING 140 164 C4-type.
FT VARSPLIC 383 383 C -> Q (in isoform Rev-erb-beta-2).
FT /FTId=VSP_003650.
FT VARSPLIC 384 578 Missing (in isoform Rev-erb-beta-2).
FT /FTId=VSP_003651.
FT CONFLICT 46 46 S -> R (in Ref. 2).
SQ SEQUENCE 578 AA; 64192 MW; E2E5370D1617AB35 CRC64;
MELNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNCD ANGNPKNTDV
SSIDGVLKSD RTDCPVKTGK PGAPGMTKSH SGMTKFSGMV LLCKVCGDVA SGFHYGVHAC
EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP
KREKQRMLIE MQSAMKTMMS TQFGGHLQSD TLAEPHEQSV PPAQEQLRPK PQLEQENIKS
TPPPSDFAKE EVIGMVTRAH KDTFLYNQEH RENSSESMPP HRGERIPRNV EQYNLNHDHR
GGGLHSHFPC SESQQHLSGQ YKGRNMMHYP NGHTVCISNG HCVNFSSAYP QRVCDRIPVG
GCSQTESRNS YLCSTGGRMH LVCPMSKSPY VDPQKSGHEI WEEFSMSFTP AVKEVVEFAK
RIPGFRDLSQ HDQVNLLKAG TFEVLMVRFA SLFDAKERTV TFLSGKKYSV DDLHSMGAGD
LLSSMFEFSE KLNGLQLSDE EMSLFTAVVL VSADRSGIEN VNSVEALQET LIRALRTLIM
KNHPNEASIF TKLLLKLPDL RSLNNMHSEE LLAFKVHP
//