Swiss-Prot entry

ID   NR1D2_MOUSE    STANDARD;      PRT;   576 AA.
AC   Q60674; Q60646;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor
DE   RVR).
GN   Name=Nr1d2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c; TISSUE=Brain;
RX   MEDLINE=95140028; PubMed=7838156 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.8.9.1234;
RA   Retnakaran R., Flock G., Giguere V.;
RT   "Identification of RVR, a novel orphan nuclear receptor that acts as a
RT   negative transcriptional regulator.";
RL   Mol. Endocrinol. 8:1234-1244(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 35-576.
RC   STRAIN=C57BL/6 X CBA; TISSUE=Liver;
RX   MEDLINE=95140030; PubMed=7838158 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.8.9.1253;
RA   Forman B.M., Chen J., Blumberg B., Kliewer S.A., Henshaw R., Ong E.,
RA   Evans R.M.;
RT   "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear
RT   receptors.";
RL   Mol. Endocrinol. 8:1253-1261(1994).
CC   -!- FUNCTION: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-
CC       ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR
CC       alpha function.
CC   -!- SUBUNIT: Interacts with NCOA5 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U12142; AAA79513.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; U09504; AAC52144.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; A57048; A57048.
DR   PDB; 1EFJ; Model; A=243-263, B=393-576. [ExPASy / RCSB]
DR   SMR; Q60674; 98-181.
DR   TRANSFAC; T04896; -.
DR   Ensembl; ENSMUSG00000041882; Mus_musculus
DR   MGD; MGI:2449205; Nr1d2.
DR   GeneLynx; Nr1d2..
DR   SOURCE; Nr1d2..
DR   GO; GO:0003700; F:transcription factor activity; IDA.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IDA.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001728; ThyrH_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; Q60674.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q60674.
DR   ProtoNet; Q60674.
DR   ProtoMap; Q60674.
DR   PRESAGE; Q60674.
DR   DIP; Q60674.
DR   ModBase; Q60674.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   3D-structure; DNA-binding; Nuclear protein; Receptor; Repressor;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DOMAIN       13     20       Poly-Ser.
FT   DOMAIN       35     39       Poly-Ser.
FT   DNA_BIND    100    176       Nuclear receptor-type.
FT   ZN_FING     103    123       C4-type.
FT   ZN_FING     140    164       C4-type.
SQ   SEQUENCE   576 AA;  64302 MW;  6620629052D2CD42 CRC64;
     MELNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNCD ANGNPKNADI
     SSIDGVLKSD RTDCPVKTGK TSAPGMTKSH SGMTKFSGMV LLCKVCGDVA SGFHYGVHAC
     EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP
     KREKQRMLIE MQSAMKTMMN TQFSGHLQND TLAEQHDQSA LPAQEQLRPK SQLEQENIKN
     TPSDFAKEEV IGMVTRAHKD TFLYNQEHRE NSSESMPPQR GERIPRNMEQ YNLNQDHRGS
     GIHNHFPCSE RQQHLSGQYK GRNIMHYPNG HAVCIANGHC MNFSSAYTQR VCDRIPVGGC
     SQTENRNSYL CNTGGRMHLV CPMSKSPYVD PQKSGHEIWE EFSMSFTPAV KEVVEFAKRI
     PGFRDLSQHD QVNLLKAGTF EVLMVRFASL FDAKERTVTF LSGKKYSVDD LHSMGAGDLL
     SSMFEFSEKL NALQLSDEEM SLFTAVVLVS ADRSGIENVN SVEALQETLI RALRTLIMKN
     HPNEASIFTK LLLKLPDLRS LNNMHSEELL AFKVHP
//