Swiss-Prot entry
ID NR1D2_HUMAN STANDARD; PRT; 579 AA.
AC Q14995; O00402; Q86XD4;
DT 15-JUL-1999 (Rel. 38, Created)
DT 15-JUL-1999 (Rel. 38, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear
DE hormone receptor BD73).
GN Name=NR1D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Kamizono A., Shuichiro K., Kohei U.;
RT "Isolation of a novel member of the thyroid/steroid hormone receptor
RT superfamily from human osteoblastic osteosarcoma HOS cell.";
RL Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood lymphocytes;
RX MEDLINE=95089782; PubMed=7997240 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.8.8.996;
RA Dumas B., Harding H.P., Choi H.-S., Lehmann K.A., Chung M.,
RA Lazar M.A., Moore D.D.;
RT "A new orphan member of the nuclear hormone receptor superfamily
RT closely related to Rev-Erb.";
RL Mol. Endocrinol. 8:996-1005(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [4]
RP INTERACTION WITH NCOA5.
RX MEDLINE=20565767; PubMed=11113208 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1128/MCB.21.1.343-353.2001;
RA Sauve F., McBroom L.D.B., Gallant J., Moraitis A.N., Labrie F.,
RA Giguere V.;
RT "CIA, a novel estrogen receptor coactivator with a bifunctional
RT nuclear receptor interacting determinant.";
RL Mol. Cell. Biol. 21:343-353(2001).
CC -!- FUNCTION: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-
CC ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR
CC alpha function (By similarity).
CC -!- SUBUNIT: Interacts with NCOA5 coactivator, leading to a strong
CC increase of transcription of target genes.
CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; D16815; BAA20088.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; L31785; AAA65937.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC045613; AAH45613.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A57057; A57057.
DR HSSP; P20393; 1A6Y. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; Q14995; 98-181.
DR TRANSFAC; T02747; -.
DR Ensembl; ENSG00000174738; Homo_sapiens
DR Genew; HGNC:7963; NR1D2.
DR CleanEx; HGNC:7963; NR1D2.
DR MIM; 602304; -. [NCBI / EBI]
DR GeneCards; NR1D2.
DR GeneLynx; NR1D2.
DR GenAtlas; NR1D2.
DR SOURCE; NR1D2.
DR GO; GO:0005634; C:nucleus; TAS.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; TAS.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; TAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; Q14995.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q14995.
DR ProtoNet; Q14995.
DR ProtoMap; Q14995.
DR PRESAGE; Q14995.
DR DIP; Q14995.
DR ModBase; Q14995.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Repressor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DOMAIN 13 20 Poly-Ser.
FT DOMAIN 35 39 Poly-Ser.
FT DNA_BIND 100 176 Nuclear receptor-type.
FT ZN_FING 103 123 C4-type.
FT ZN_FING 140 164 C4-type.
FT CONFLICT 21 21 P -> H (in Ref. 3).
FT CONFLICT 282 282 Q -> K (in Ref. 3).
FT CONFLICT 288 288 P -> R (in Ref. 3).
FT CONFLICT 519 520 IE -> NRK (in Ref. 2).
SQ SEQUENCE 579 AA; 64643 MW; 38F82863D7F8E00F CRC64;
MEVNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL
ANIEGILKND RIDCSMKTSK SSAPGMTKSH SGVTKFSGMV LLCKVCGDVA SGFHYGVHAC
EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP
KREKQRMLIE MQSAMKTMMN SQFSGHLQND TLVEHHEQTA LPAQEQLRPK PQLEQENIKS
SSPPSSDFAK EEVIGMVTRA HKDTFMYNQE QQENSAESMQ PQRGERIPKN MEQYNLNHDH
CGNGLSSHFP CSESQQHLNG QFKGRNIMHY PNGHAICIAN GHCMNFSNAY TQRVCDRVPI
DGFSQNENKN SYLCNTGGRM HLVCPMSKSP YVDPHKSGHE IWEEFSMSFT PAVKEVVEFA
KRIPGFRDLS QHDQVNLLKA GTFEVLMVRF ASLFDAKERT VTFLSGKKYS VDDLHSMGAG
DLLNSMFEFS EKLNALQLSD EEMSLFTAVV LVSADRSGIE NVNSVEALQE TLIRALRTLI
MKNHPNEASI FTKLLLKLPD LRSLNNMHSE ELLAFKVHP
//