Swiss-Prot entry
ID NR1D1_HUMAN STANDARD; PRT; 614 AA.
AC P20393; Q15304;
DT 01-FEB-1991 (Rel. 17, Created)
DT 01-FEB-1991 (Rel. 17, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Orphan nuclear receptor NR1D1 (V-erbA related protein EAR-1) (Rev-
DE erbA-alpha).
GN Name=NR1D1; Synonyms=EAR1, HREV, THRAL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE, FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX MEDLINE=89195219; PubMed=2539258 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0092-8674(89)90169-4;
RA Miyajima N., Horiuchi R., Shibuya Y., Fukushige S.-I.,
RA Matsubara K.-I., Toyoshima K., Yamamoto T.;
RT "Two erbA homologs encoding proteins with different T3 binding
RT capacities are transcribed from opposite DNA strands of the same
RT genetic locus.";
RL Cell 57:31-39(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE, AND FUNCTION.
RC TISSUE=Fetal skeletal muscle;
RX MEDLINE=90262650; PubMed=1971514 [NCBI, ExPASy, EBI, Israel, Japan];
RA Lazar M.A., Jones K.E., Chin W.W.;
RT "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from
RT the noncoding DNA strand of a thyroid hormone receptor gene results in
RT a related protein that does not bind thyroid hormone.";
RL DNA Cell Biol. 9:77-83(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 549-614.
RX MEDLINE=91212192; PubMed=1850510 [NCBI, ExPASy, EBI, Israel, Japan];
RA Laudet V., Begue A., Henry C., Joubel A., Martin P., Stehelin D.,
RA Saule S.;
RT "Genomic organization of the human thyroid hormone receptor alpha (c-
RT erbA-1) gene.";
RL Nucleic Acids Res. 19:1105-1112(1991).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 123-215.
RX MEDLINE=98325398; PubMed=9660968 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S1097-2765(00)80084-2;
RA Zhao Q., Khorasanizadeh S., Miyoshi Y., Lazar M.A., Rastinejad F.;
RT "Structural elements of an orphan nuclear receptor-DNA complex.";
RL Mol. Cell 1:849-861(1998).
CC -!- FUNCTION: Possible receptor for triiodothyronine.
CC -!- SUBCELLULAR LOCATION: Nuclear (Potential).
CC -!- TISSUE SPECIFICITY: Expressed in all tissues and cell lines
CC examined. Expressed at high levels in some squamous carcinoma cell
CC lines.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; M24898; AAA52335.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M24900; AAA52332.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X55066; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X55067; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X72631; CAB53540.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC056148; AAH56148.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M34339; AAA36561.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M34340; AAA36562.2; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A32286; A32608.
DR PDB; 1A6Y; X-ray; A/B=123-216. [ExPASy / RCSB]
DR PDB; 1EF6; Model; A=281-301, B=430-614. [ExPASy / RCSB]
DR PDB; 1GA5; X-ray; A/B/E/F=123-216. [ExPASy / RCSB]
DR PDB; 1HLZ; X-ray; A/B=123-216. [ExPASy / RCSB]
DR TRANSFAC; T02746; -.
DR Ensembl; ENSG00000126368; Homo_sapiens
DR Genew; HGNC:7962; NR1D1.
DR CleanEx; HGNC:7962; NR1D1.
DR MIM; 602408; -. [NCBI / EBI]
DR GeneCards; NR1D1.
DR GeneLynx; NR1D1.
DR GenAtlas; NR1D1.
DR SOURCE; NR1D1.
DR GO; GO:0005634; C:nucleus; TAS.
DR GO; GO:0003707; F:steroid hormone receptor activity; TAS.
DR GO; GO:0003714; F:transcription corepressor activity; TAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P20393.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P20393.
DR ProtoNet; P20393.
DR ProtoMap; P20393.
DR PRESAGE; P20393.
DR DIP; P20393.
DR ModBase; P20393.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW 3D-structure; DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DOMAIN 82 93 Poly-Ser.
FT DNA_BIND 129 205 Nuclear receptor-type.
FT ZN_FING 132 152 C4-type.
FT ZN_FING 169 193 C4-type.
FT CONFLICT 147 147 H -> L (in Ref. 2).
FT CONFLICT 564 564 E -> Q (in Ref. 2).
FT STRAND 131 131
FT TURN 133 135
FT STRAND 138 138
FT STRAND 143 143
FT TURN 144 145
FT STRAND 146 146
FT HELIX 150 160
FT TURN 161 161
FT TURN 170 171
FT TURN 179 184
FT HELIX 186 196
FT TURN 197 197
FT TURN 200 201
SQ SEQUENCE 614 AA; 66805 MW; 67C71758E166508A CRC64;
MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDNSNGS FQSLTQGCPT YFPPSPTGSL
TQDPARSFGS IPPSLSDDGS PSSSSSSSSS SSSFYNGSPP GSLQVAMEDS SRVSPSKSTS
NITKLNGMVL LCKVCGDVAS GFHYGVHACE GCKGFFRRSI QQNIQYKRCL KNENCSIVRI
NRNRCQQCRF KKCLSVGMSR DAVRFGRIPK REKQRMLAEM QSAMNLANNQ LSSQCPLETS
PTQHPTPGPM GPSPPPAPVP SPLVGFSQFP QQLTPPRSPS PEPTVEDVIS QVARAHREIF
TYAHDKLGSS PGNFNANHAS GSPPATTPHR WENQGCPPAP NDNNTLAAQR HNEALNGLRQ
APSSYPPTWP PGPAHHSCHQ SNSNGHRLCP THVYAAPEGK APANSPRQGN SKNVLLACPM
NMYPHGRSGR TVQEIWEDFS MSFTPAVREV VEFAKHIPGF RDLSQHDQVT LLKAGTFEVL
MVRFASLFNV KDQTVMFLSR TTYSLQELGA MGMGDLLSAM FDFSEKLNSL ALTEEELGLF
TAVVLVSADR SGMENSASVE QLQETLLRAL RALVLKNRPL ETSRFTKLLL KLPDLRTLNN
MHSEKLLSFR VDAQ
//