Swiss-Prot entry
ID NHR23_CAEEL STANDARD; PRT; 588 AA.
AC P41828; Q17380; Q17584; Q9BJL3;
DT 01-NOV-1995 (Rel. 32, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Nuclear hormone receptor family member nhr-23 (Steroid hormone
DE receptor family member chr-3).
GN Name=nhr-23; Synonyms=chr-3; ORFNames=C01H6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM B).
RC STRAIN=Bristol N2;
RX MEDLINE=95116514; PubMed=7816808 [NCBI, ExPASy, EBI, Israel, Japan];
RA Kostrouch Z., Kostrouchova M., Rall J.E.;
RT "Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:156-159(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM A).
RA Bogan A., Maina C.V., Yamamoto K., Cohen F., Sluder A.E.;
RT "Caenorhabditis elegans nuclear receptor sequences exhibit biophysical
RT compatibility with the ligand-binding domain fold.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP SPLICING.
RC STRAIN=Bristol N2;
RX MEDLINE=99069613; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan];
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 36-73.
RC STRAIN=Bristol N2;
RA Kostrouchova M., Kostrouch Z., Krause M., Rall J.E.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nuclear (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P41828-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P41828-2; Sequence=VSP_003722;
CC -!- TISSUE SPECIFICITY: Expressed in both larval and adult tissues.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; U13075; AAA96983.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U51231; AAA97463.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U51136; AAA96057.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF332203; AAK17974.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF332202; AAK17973.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; Z71258; CAD30427.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; Z71258; CAA95782.2; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR WormBase; WBGene00003622; C01H6.5.
DR WormPep; C01H6.5a; CE24775. [WormPep / WormBase / WorfDB]
DR WormPep; C01H6.5b; CE30478. [WormPep / WormBase / WorfDB]
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P41828.
DR BLOCKS; P41828.
DR ProtoNet; P41828.
DR ProtoMap; P41828.
DR PRESAGE; P41828.
DR DIP; P41828.
DR ModBase; P41828.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; DNA-binding; Nuclear protein; Receptor;
KW Transcription; Transcription regulation; Zinc-finger.
FT DNA_BIND 160 235 Nuclear receptor-type.
FT ZN_FING 163 183 C4-type.
FT ZN_FING 199 223 C4-type.
FT VARSPLIC 1 35 Missing (in isoform b).
FT /FTId=VSP_003722.
FT CONFLICT 17 23 EMSSFVY -> YPPVTNS (in Ref. 2; AAK17973).
FT CONFLICT 565 565 R -> Q (in Ref. 1).
SQ SEQUENCE 588 AA; 65332 MW; 065075FF428DF6EB CRC64;
MACKVTGPNR HLTSVLEMSS FVYWPRSRQQ AHNFPMQAVE QKLADATRTL HAKSSLQPSL
SIETPKSKEN DESGCESSNC MFHPHTIKSE PNFCFAREFK SVPDDFRIGG GDLQMGNNSK
RLTCVIDTNR VDMAGILPDN MSFRGLPENK SLLVSAQIEV IPCKVCGDKS SGVHYGVITC
EGCKGFFRRS QSSIVNYQCP RQKNCVVDRV NRNRCQYCRL KKCIELGMSR DAVKFGRMSK
KQREKVEDEV RMHKELAANG LGYQAIYGDY SPPPSHPSYC FDQSMYGHYP SGTSTPVNGY
SIAVAATPTT PMPQNMYGAT PSSTNGTQYV AHQATGGSFP SPQVPEEDVA TRVIRAFNQQ
HSSYTTQHGV CNVDPDCIPH LSRAGGWELF ARELNPLIQA IIEFAKSIDG FMNLPQETQI
QLLKGSVFEL SLVFAAMYYN VDAQAVCGER YSVPFACLIA EDDAEMQLIV EVNNTLQEIV
HLQPHQSELA LLAAGLILEQ VSSSHGIGIL DTATIATAET LKNALYQSVM PRIGCMEDTI
HRIQDVETRI RQTARLHQEA LQNFRMSDPT SSEKLPALYK ELFTADRP
//