Swiss-Prot entry

ID   MCR_XENLA      STANDARD;      PRT;   612 AA.
AC   Q91573; Q91723;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Mineralocorticoid receptor (MR) (Fragment).
GN   Name=NR3C2; Synonyms=MLR;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=95258646; PubMed=7740172 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Csikos T., Tay J., Danielsen M.;
RT   "Expression of the Xenopus laevis mineralocorticoid receptor during
RT   metamorphosis.";
RL   Recent Prog. Horm. Res. 50:393-396(1995).
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC       aldosterone and glucocorticoids (GC) such as corticosterone or
CC       cortisol. Binds to mineralocorticoid response elements (MRE) and
CC       transactivates target genes. The effect of MC is to increase ion
CC       and water transport and thus raise extracellular fluid volume and
CC       blood pressure and lower potassium levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear in the absence of
CC       ligand; nuclear after ligand-binding (By similarity).
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U15133; AAA75574.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; U15135; AAA75575.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P06536; 1RGD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q91573; 224-303.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q91573.
DR   ProtoNet; Q91573.
DR   ProtoMap; Q91573.
DR   PRESAGE; Q91573.
DR   DIP; Q91573.
DR   ModBase; Q91573.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Metal-binding; Nuclear protein; Receptor;
KW   Steroid-binding; Trans-acting factor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   NON_TER       1      1
FT   DOMAIN       <1    228       Modulating.
FT   DNA_BIND    229    298       Nuclear receptor-type.
FT   ZN_FING     229    249       C4-type.
FT   ZN_FING     269    293       C4-type.
FT   DOMAIN      299    360       Hinge.
FT   DOMAIN      361    612       Steroid-binding.
SQ   SEQUENCE   612 AA;  67946 MW;  CDD66DDC0A5FBA08 CRC64;
     GNEIADSTVS LVKFIKPDPD AIFSSTCFGD TVSSDPAFSI PIKQESCKNT CSSALFKGSQ
     SANPFPFMDG SYFAFMDDKD YYSLSGILGP PVSSFGDGFE GNGFSNQSLN VAIKQETEDS
     SFYPENNMPS SAIVGVNSCG QSFHYRIGAQ GTISLSRPLN RDQSFQNLSS FPPMSSLVES
     WKTQSELAQN TLSSRRNDGF PVPGYIPENM SSTTLRSMST GPSRPSKVCL VCGDEASGCH
     YGVVTCGSCK VFFKRAVEGK CSRQHSYLCA GRNDCIIDKI RRKNCPACRL QKCLQAGMNL
     GARKSKKLGK LKGVHEEHPQ QPLQQTPTAS PKEDTTLTSS SKEPSANSNS LVPLISAVSP
     AITLSAAVIL ENIEPEIVYA GYDNTQPDTA ENLLSSLNQL AGKQMVQVVK WAKVIPGFRN
     LPLEDQITLI QYSWMCLSSF ALSWRSYKHA SSQFLYFAPD LIFNEERMRQ SAMYDLCQGM
     QQISLEFSRL QLTFEEYTLM KVLLLLSTVP KDGLKCQAAF EEMRVNYIKE LRKVLLKSPH
     NSGQSWQRYF QLTKLLDSMQ DLVGDLLEFC FYTFRESQAL KVEFPAMLVE IISDQLPKVE
     SGIAKPLYFH RK
//