Swiss-Prot entry
ID MCR_MOUSE STANDARD; PRT; 978 AA.
AC Q8VII8; Q8VII9;
DT 10-OCT-2003 (Rel. 42, Created)
DT 10-OCT-2003 (Rel. 42, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Mineralocorticoid receptor (MR).
GN Name=Nr3c2; Synonyms=Mlr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The mouse genome sequencing consortium;
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE OF 5-109 AND 182-288.
RC STRAIN=C57BL/6 X DBA/2; TISSUE=Heart;
RX MEDLINE=22008052; PubMed=11997477 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.102673599;
RA Beggah A.T., Escoubet B., Puttini S., Cailmail S., Delage V.,
RA Ouvrard-Pascaud A., Bocchi B., Peuchmaur M., Delcayre C., Farman N.,
RA Jaisser F.;
RT "Reversible cardiac fibrosis and heart failure induced by conditional
RT expression of an antisense mRNA of the mineralocorticoid receptor in
RT cardiomyocytes.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:7160-7165(2002).
CC -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as
CC aldosterone and glucocorticoids (GC) such as corticosterone or
CC cortisol. Binds to mineralocorticoid response elements (MRE) and
CC transactivates target genes. The effect of MC is to increase ion
CC and water transport and thus raise extracellular fluid volume and
CC blood pressure and lower potassium levels (By similarity).
CC -!- SUBUNIT: Heteromultimeric cytoplasmic complex with HSP90, HSP70,
CC and FKBP4, in the absence of ligand. After ligand binding, it
CC translocates to the nucleus and binds to DNA as a homodimer and as
CC a heterodimer with NR3C1. Binds the coactivator NCOA2. May
CC interact with HSD11B2 in the absence of ligand. Binds the
CC coactivators NCOA1, TIF1 and NRIP1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear in the absence of
CC ligand; nuclear after ligand-binding. When bound to HSD11B2, it is
CC found associated with the endoplasmic reticulum membrane (By
CC similarity).
CC -!- TISSUE SPECIFICITY: Expressed in heart.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC -!- PTM: Phosphorylated (By similarity).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC -!- CAUTION: This is a conceptual translation.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AC119248; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080033; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080036; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080039; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080042; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080047; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080050; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080053; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080056; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080059; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080062; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01080065; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01100710; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01129938; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01140030; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01163128; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01172228; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01183864; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01198618; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01203955; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01204039; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01215941; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; CAAA01219625; -; NOT_ANNOTATED_CDS. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ311855; CAC86374.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ311856; CAC86375.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P06536; 1RGD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; Q8VII8; 598-675.
DR Ensembl; ENSMUSG00000031618; Mus_musculus
DR MGD; MGI:99459; Nr3c2.
DR GeneLynx; Nr3c2..
DR SOURCE; Nr3c2..
DR GO; GO:0005515; F:protein binding; IPI.
DR GO; GO:0005496; F:steroid binding; IDA.
DR GO; GO:0007588; P:excretion; IMP.
DR GO; GO:0006883; P:sodium ion homeostasis; IMP.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; Q8VII8.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q8VII8.
DR ProtoNet; Q8VII8.
DR ProtoMap; Q8VII8.
DR PRESAGE; Q8VII8.
DR DIP; Q8VII8.
DR ModBase; Q8VII8.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Metal-binding; Nuclear protein; Phosphorylation;
KW Receptor; Steroid-binding; Trans-acting factor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT DOMAIN 1 602 Modulating.
FT DNA_BIND 603 666 Nuclear receptor-type.
FT ZN_FING 603 623 C4-type.
FT ZN_FING 637 661 C4-type.
FT DOMAIN 667 726 Hinge.
FT DOMAIN 727 978 Steroid-binding.
FT CONFLICT 103 103 E -> Q (in Ref. 2; CAC86374).
FT CONFLICT 106 106 G -> D (in Ref. 2; CAC86374).
SQ SEQUENCE 978 AA; 106447 MW; 4D6F2C870FB4050A CRC64;
METKGYHSLP EGLDMERRWS QVSQTLERSS LGPAERTNEN SYMEIVNVSC VSGATPNNST
QGSSKEKHEL LPCLQQDNSR SGILPSDIKT ELESKELSAT VAESMGLYMD SVRDAEYTYD
QQNQQGSLSP AKIYQNMEQL VKFYKENGHR SSTLSAISRP LRSFMPDSGT SMNGGALRAI
VKSPIICHEK SPSVCSPLNM PSSVCSPAGI NSMSSSTASF GSFPVHSPIT QGTSLTCSPS
VENRGSRSHS PVHASNVGSP LSSPLSSMKS PISSPPSHCS VKSPVSSPNN VPLRSSVSSP
ANLNNSRCSV SSPSNTNNRS TLSSPTASTV GSIGSPISNA FSYTTSGASA GAGAIQDMVP
SPDTHEKGAH DVPFPKTEEV EKAISNGVTG QLNIVQYIKP EPDGAFSSSC LGGNNKINPS
SPFSVPIKQE SSKHSCSGAS FKGNPTVNPF PFMDGSYFSF MDDKDYYSLS GILGPPVPGF
DSSCEGSAFP GGIKQEPDDG SYFPETSIPS SAIIGVNSGG QSFHYRIGAQ GTISLSRSPR
DQSFQHLSSF PPVNALVESW KPHGDLSSRR SDGYPVLEYI PENVSSSTLR SVSTGSSRPS
KICLVCGDEA SGCHYGVVTC GSCKVFFKRA VEHNYLCAGR NDCIIDKIRR KNCPACRLQK
CLQAGMNLGA RKSKKLGKLK GLHEEQPQQP PPPPPQSPEE GTTYIAPTKE PSVNSALVPQ
LASITRALTP SPSMILENIE PEIVYAGYDN SKPDTAESLL STLNRLAGKQ MIQVVKWAKV
LPGFKNLPLE DQITLIQYSW MCLSSFALSW RSYKHTNSQF LYFAPDLVFN EEKMHQSAMY
ELCQGMRQIS LQFVRLQLTF EEYSIMKVLL LLSTVPKDGL KSQAAFEEMR TNYIKELRKM
VTKCPNSSGQ SWQRFYQLTK LLDSMHDLVN DLLEFCFYTF RESQALKVEF PAMLVEIISD
QLPKVESGNA KPLYFHRK
//