Swiss-Prot entry
ID HR96_DROME STANDARD; PRT; 723 AA.
AC Q24143; Q9VBZ7;
DT 01-NOV-1997 (Rel. 35, Created)
DT 01-NOV-1997 (Rel. 35, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Nuclear hormone receptor HR96 (dHR96).
GN Name=Hr96; Synonyms=NR1J1; ORFNames=CG11783;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION.
RX MEDLINE=96068664; PubMed=7479849 [NCBI, ExPASy, EBI, Israel, Japan];
RA Fisk G.J., Thummel C.S.;
RT "Isolation, regulation, and DNA-binding properties of three Drosophila
RT nuclear hormone receptor superfamily members.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:10604-10608(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., MosHREFi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan];
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX MEDLINE=22426066; PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan];
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Binds selectively to the HSP27 20E response element.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- DEVELOPMENTAL STAGE: Highest expression in third-instar larvae and
CC prepupae.
CC -!- INDUCTION: By 20-hydroxyecdysone (20HE) 106 hours after egg
CC laying.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; U36792; AAC46928.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AE003750; AAF56379.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AY051486; AAK92910.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P11473; 1KB2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR TRANSFAC; T02756; -.
DR Ensembl; CG11783; Drosophila_melanogaster
DR FlyBase; FBgn0015240; Hr96.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; NAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; Q24143.
DR BLOCKS; Q24143.
DR ProtoNet; Q24143.
DR ProtoMap; Q24143.
DR PRESAGE; Q24143.
DR DIP; Q24143.
DR ModBase; Q24143.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DNA_BIND 4 79 Nuclear receptor-type.
FT ZN_FING 7 27 C4-type.
FT ZN_FING 43 67 C4-type.
SQ SEQUENCE 723 AA; 81029 MW; 439CC96A723AE9B6 CRC64;
MSPPKNCAVC GDKALGYNFN AVTCESCKAF FRRNALAKKQ FTCPFNQNCD ITVVTRRFCQ
KCRLRKCLDI GMKSENIMSE EDKLIKRRKI ETNRAKRRLM ENGTDACDAD GGEERDHKAP
ADSSSSNLDH YSGSQDSQSC GSADSGANGC SGRQASSPGT QVNPLQMTAE KIVDQIVSDP
DRASQAINRL MRTQKEAISV MEKVISSQKD ALRLVSHLID YPGDALKIIS KFMNSPFNAL
TVFTKFMSSP TDGVEIISKI VDSPADVVEF MQNLMHSPED AIDIMNKFMN TPAEALRILN
RILSGGGANA AQQTADRKPL LDKEPAVKPA APAERADTVI QSMLGNSPPI SPHDAAVDLQ
YHSPGVGEQP STSSSHPLPY IANSPDFDLK TFMQTNYNDE PSLDSDFSIN SIESVLSEVI
RIEYQAFNSI QQAASRVKEE MSYGTQSTYG GCNSAANNSQ PHLQQPICAP STQQLDRELN
EAEQMKLREL RLASEALYDP VDEDLSALMM GDDRIKPDDT RHNPKLLQLI NLTAVAIKRL
IKMAKKITAF RDMCQEDQVA LLKGGCTEMM IMRSVMIYDD DRAAWKVPHT KENMGNIRTD
LLKFAEGNIY EEHQKFITTF DEKWRMDENI ILIMCAIVLF TSARSRVIHK DVIRLEQNSY
YYLLRRYLES VYSGCEARNA FIKLIQKISD VERLNKFIIN VYLNVNPSQV EPLLREIFDL
KNH
//