Swiss-Prot entry

ID   HR78_DROME     STANDARD;      PRT;   601 AA.
AC   Q24142; Q24108;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Nuclear hormone receptor HR78 (dHR78) (Nuclear receptor XR78E/F).
GN   Name=Hr78; Synonyms=Hr78D, NR2D1;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; 
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; 
OC   Ephydroidea; Drosophilidae; Drosophila. 
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION.
RX   MEDLINE=96068664; PubMed=7479849 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Fisk G.J., Thummel C.S.;
RT   "Isolation, regulation, and DNA-binding properties of three Drosophila
RT   nuclear hormone receptor superfamily members.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:10604-10608(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=96068638; PubMed=7479823 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Zelhof A.C., Yao T.P., Evans R.M., McKeown M.;
RT   "Identification and characterization of a Drosophila nuclear receptor
RT   with the ability to inhibit the ecdysone response.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:10477-10481(1995).
CC   -!- FUNCTION: Binds to direct repeats of the sequence 5'-AGGTCA-3'.
CC       Inhibits the ecdysone response.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- DEVELOPMENTAL STAGE: Highest expression in third-instar larvae and
CC       prepupae.
CC   -!- INDUCTION: By 20-hydroxyecdysone (20HE) 106 hours after egg
CC       laying.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U36791; AAC46927.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; U31517; AAC46924.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P19793; 2NLL. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   TRANSFAC; T02759; -.
DR   Ensembl; CG7199; Drosophila_melanogaster
DR   FlyBase; FBgn0015239; Hr78.
DR   GO; GO:0005634; C:nucleus; IDA.
DR   GO; GO:0004879; F:ligand-dependent nuclear receptor activity; IDA.
DR   GO; GO:0035071; P:salivary gland cell death; IEP.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   CMR; Q24142.
DR   BLOCKS; Q24142.
DR   ProtoNet; Q24142.
DR   ProtoMap; Q24142.
DR   PRESAGE; Q24142.
DR   DIP; Q24142.
DR   ModBase; Q24142.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DNA_BIND     49    124       Nuclear receptor-type.
FT   ZN_FING      52     72       C4-type.
FT   ZN_FING      88    112       C4-type.
FT   DOMAIN      215    226       Poly-Gln.
FT   CONFLICT    142    142       G -> S (in Ref. 2).
FT   CONFLICT    178    188       ATPPVHSAPAT -> PRLQCTARQQR (in Ref. 2).
FT   CONFLICT    194    197       ENIF -> AEYI (in Ref. 2).
FT   CONFLICT    277    277       A -> V (in Ref. 2).
FT   CONFLICT    517    517       L -> F (in Ref. 2).
FT   CONFLICT    519    519       Q -> H (in Ref. 2).
SQ   SEQUENCE   601 AA;  65335 MW;  AFE0D82CEEEA0654 CRC64;
     MDGVKVETFI KSEENRAMPL IGGGSASGGT PLPGGGVGMG AGASATLSVE LCLVCGDRAS
     GRHYGAISCE GCKGFFKRSI RKQLGYQCRG AMNCEVTKHH RNRCQFCRLQ KCLASGMRSD
     SVQHERKPIV DRKEGIIAAA GGSSTSGGGN GSSTYLSGKS GYQQGRGKGH SVKAESAATP
     PVHSAPATAF NLNENIFPMG LNFAELTQTL MFATQQQQQQ QQQHQQSGSY SPDIPKADPE
     DDEDDSMDNS STLCLQLLAN SASNNNSQHL NFNAGEAPTA LPTTSTMGLI QSSLDMRVIH
     KGLQILQPIQ NQLERNGNLS VKPECDSEAE DSGTEDAVDA ELEHMELDFE CGGNRSGGSD
     FAINEAVFEQ DLLTDVQCAF HVQPPTLVHS YLNIHYVCET GSRIIFLTIH TLRKVPVFEQ
     LEAHTQVKLL RGVWPALMAI ALAQCQGQLS VPTIIGQFIQ STRQLADIDK IEPLKISKMA
     NLTRTLHDFV QELQSLDVTD MEFGLLRLIL LFNPTLLQQR KERSLRGYVR RVQLYALSSL
     RRQGGIGGGE ERFNVLVARL LPLSSLDAEA MEELFFANLV GQMQMDALIP FILMTSNTSG
     L
//