Swiss-Prot entry
ID HR3_DROME STANDARD; PRT; 487 AA.
AC P31396; Q9V5I0;
DT 01-JUL-1993 (Rel. 26, Created)
DT 01-JUL-1993 (Rel. 26, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Probable nuclear hormone receptor HR3 (dHR3).
GN Name=Hr46; Synonyms=Hr3, NR1F4; ORFNames=CG11823;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92335259; PubMed=1631105 [NCBI, ExPASy, EBI, Israel, Japan];
RA Koelle M.R., Segraves W.A., Hogness D.S.;
RT "DHR3: a Drosophila steroid receptor homolog.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:6167-6171(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., MosHREFi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan];
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Putative receptor whose ligand is not yet known.
CC -!- SUBCELLULAR LOCATION: Nuclear (Potential).
CC -!- INDUCTION: The expression of this protein is developmentally
CC regulated showing peaks at midembryogenesis. HR3 transcription is
CC ecdysone-induced.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; M90806; AAA28461.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AE003830; AAF58826.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A46146; A46146.
DR HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR TRANSFAC; T02750; -.
DR Ensembl; CG33183; Drosophila_melanogaster
DR FlyBase; FBgn0000448; Hr46.
DR GO; GO:0005634; C:nucleus; IDA.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; IDA.
DR GO; GO:0046698; P:metamorphosis (sensu Insecta); TAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P31396.
DR BLOCKS; P31396.
DR ProtoNet; P31396.
DR ProtoMap; P31396.
DR PRESAGE; P31396.
DR DIP; P31396.
DR ModBase; P31396.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DNA_BIND 48 123 Nuclear receptor-type.
FT ZN_FING 51 71 C4-type.
FT ZN_FING 87 111 C4-type.
FT DOMAIN 255 487 Ligand-binding (Potential).
SQ SEQUENCE 487 AA; 55285 MW; 774587D2E79204EC CRC64;
MYTQRMFDMW SSVTSKLEAH ANNLGQSNVQ SPAGQNNSSG SIKAQIEIIP CKVCGDKSSG
VHYGVITCEG CKGFFRRSQS SVVNYQCPRN KQCVVDRVNR NRCQYCRLQK CLKLGMSRDA
VKFGRMSKKQ REKVEDEVRF HRAQMRAQSD AAPDSSVYDT QTPSSSDQLH HNNYNSYSGG
YSNNEVGYGS PYGYSASVTP QQTMQYDISA DYVDSTTYEP RSTIIDPEFI SHADGDINDV
LIKTLAEAHA NTNTKLEAVH DMFRKQPDVS RILYYKNLGQ EELWLDCAEK LTQMIQNIIE
FAKLIPGFMR LSQDDQILLL KTGSFELAIV RMSRLLDLSQ NAVLYGDVML PQEAFYTSDS
EEMRLVSRIF QTAKSIAELK LTETELALYQ SLVLLWPERN GVRGNTEIQR LFNLSMNAIR
QELETNHAPL KGDVTVLDTL LNNIPNFRDI SILHMESLSK FKLQHPNVVF PALYKELFSI
DSQQDLT
//