Swiss-Prot entry
ID HNF4_DROME STANDARD; PRT; 666 AA.
AC P49866; Q9VLI8;
DT 01-OCT-1996 (Rel. 34, Created)
DT 16-OCT-2001 (Rel. 40, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Transcription factor HNF-4 homolog (dHNF4).
GN Name=Hnf4; Synonyms=NR2A4; ORFNames=CG9310;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary;
RX MEDLINE=93178427; PubMed=8440243 [NCBI, ExPASy, EBI, Israel, Japan];
RA Zhong W., Sladek F.M., Darnell J.E. Jr.;
RT "The expression pattern of a Drosophila homolog to the mouse
RT transcription factor HNF-4 suggests a determinative role in gut
RT formation.";
RL EMBO J. 12:537-544(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., MosHREFi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan];
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Transcriptionally controlled transcription factor.
CC Important for the differentiation of various specialized cell
CC types that arise from both endoderm and mesoderm. May have a role
CC in early gut formation.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- TISSUE SPECIFICITY: In developing embryos it is expressed in mid-
CC gut, fat bodies and the distal region of Malpighian tubules.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; U70874; AAB09592.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AE003622; AAF52703.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S36218; S36218.
DR HSSP; P22449; 1M7W. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR TRANSFAC; T02739; -.
DR Ensembl; CG9310; Drosophila_melanogaster
DR FlyBase; FBgn0004914; Hnf4.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; NAS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR000003; RtnoidX_receptor.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00545; RETINOIDXR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P49866.
DR BLOCKS; P49866.
DR ProtoNet; P49866.
DR ProtoMap; P49866.
DR PRESAGE; P49866.
DR DIP; P49866.
DR ModBase; P49866.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DNA_BIND 101 176 Nuclear receptor-type.
FT ZN_FING 104 124 C4-type.
FT ZN_FING 140 164 C4-type.
FT DOMAIN 66 69 Poly-Asn.
FT DOMAIN 89 99 Poly-Gln.
FT DOMAIN 511 517 Poly-Ala.
FT DOMAIN 519 523 Poly-Ser.
FT DOMAIN 553 556 Poly-Gln.
FT DOMAIN 601 606 Poly-Gly.
FT CONFLICT 75 75 N -> Y (in Ref. 1).
FT CONFLICT 79 79 S -> N (in Ref. 1).
SQ SEQUENCE 666 AA; 71900 MW; 97D9A44B7634BACD CRC64;
MHADALASAY PAASQPHSPI GLALSPNGGG LGLSNSSNQS SENFALCNGN GNAGSAGGGS
ASSGSNNNNS MFSPNNNLSG SGSGTNSSQQ QLQQQQQQQS PTVCAICGDR ATGKHYGASS
CDGCKGFFRR SVRKNHQYTC RFARNCVVDK DKRNQCRYCR LRKCFKAGMK KEAVQNERDR
ISCRRTSNDD PDPGNGLSVI SLVKAENESR QSKAGAAMEP NINEDLSNKQ FASINDVCES
MKQQLLTLVE WAKQIPAFNE LQLDDQVALL RAHAGEHLLL GLSRRSMHLK DVLLLSNNCV
ITRHCPDPLV SPNLDISRIG ARIIDELVTV MKDVGIDDTE FACIKALVFF DPNAKGLNEP
HRIKSLRHQI LNNLEDYISD RQYESRGRFG EILLILPVLQ SITWQMIEQI QFAKIFGVAH
IDSLLQEMLL GGELADNPLP LSPPNQSNDY QSPTHTGNME GGNQVNSSLD SLATSGGPGS
HSLDLEVQHI QALIEANSAD DSFRAYAAST AAAAAAAVSS SSSAPASVAP ASISPPLNSP
KSQHQHQQHA THQQQQESSY LDMPVKHYNG SRSGPLPTQH SPQRMHPYQR AVASPVEVSS
GGGGLGLRNP ADITLNEYNR SEGSSAEELL RRTPLKIRAP EMLTAPAGYG TEPCRMTLKQ
EPETGY
//