Swiss-Prot entry

ID   GCR_PAROL      STANDARD;      PRT;   807 AA.
AC   O73673;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Glucocorticoid receptor (GR).
GN   Name=NR3C1; Synonyms=GRL;
OS   Paralichthys olivaceus (Japanese flounder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; 
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Pleuronectiformes; 
OC   Pleuronectoidei; Paralichthyidae; Paralichthys. 
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver;
RA   Tokuda Y.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of
CC       action: as a transcription factor that binds to glucocorticoid
CC       response elements (GRE) and as a modulator of other transcription
CC       factors. Affects inflammatory responses, cellular proliferation
CC       and differentiation in target tissues (By similarity).
CC   -!- SUBUNIT: Heteromultimeric cytoplasmic complex with HSP90. Upon
CC       ligand binding the complex undergoes a conformation change and
CC       moves to the nucleus, where it dissociates. Binds to DNA as a
CC       homodimer, and as heterodimer with NR3C2. Interaction with
CC       numerous other transcription factors modulates transcription
CC       activation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic in the absence of ligand;
CC       nuclear after ligand-binding (By similarity).
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AB013444; BAA25997.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P06536; 1RGD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O73673; 439-524, 555-807.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O73673.
DR   ProtoNet; O73673.
DR   ProtoMap; O73673.
DR   PRESAGE; O73673.
DR   DIP; O73673.
DR   ModBase; O73673.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Trans-acting factor; Transcription; Transcription regulation;
KW   Zinc-finger.
FT   DOMAIN        1    444       Modulating.
FT   DNA_BIND    445    519       Nuclear receptor-type.
FT   ZN_FING     445    465       C4-type.
FT   ZN_FING     490    514       C4-type.
FT   DOMAIN      520    560       Hinge.
FT   DOMAIN      561    807       Steroid-binding.
SQ   SEQUENCE   807 AA;  88986 MW;  F075E7784A394728 CRC64;
     MDQGGLKRNC NRDDSLTFGE TAVGVGSDTG DTAGSLLQPA AMHLPSPSSL PQLTVAPNGG
     AGTKDQGEFG GLFESPRGQC EGSEMKEGKI IRLQKRKHHL DIGMFNMEDN LSLLNQNISD
     LNRTSTSVIS TSDTSVLGKL PLPNLFPQHI KQEGGFSLEK ELGTYGGHTG GGPCDLDGNS
     GHLIEDTEIW QDLDLPNSLP EISDFELDSE VAHLDNILHD SSGGCGPDGS LLKETKVLVG
     NGGNCTDVNG TDQQHPLQHH QHQQQQHRHL LQHQQHQLHH QHQQPPSLLS SVMIKEEKDH
     DNSFIHIRTP GVVKQEKQEN GSFCQSQCLQ SSMSSLHGGG PMSSTMGAGA VPGYHYKASP
     SSTVGLQDQK PFGIFSNLPA VAESWTRGGR FGEPSGIQRG NDGLPSAAMS PFSVSFSSSS
     PRTGENSSSA VPGLSKPSGP THKICLVCSD EASGCHYGVV TCGSCKVFFK RAVEGWRARQ
     NTDGQHNYLC AGRNDCIIDK IRRKNCPACR FRKCLQAGMN LEARKNKKLI KMKVHRPTGS
     AEPISNMPVP VIPRMPQLVP TMLSVLKAIE PEIIYSGYDS TLPDTSTRLM TTLNRLGGQQ
     VISAVKWAKS LPGFRNLHLD DQMTLLQCSW LFLMSFSLGW RSYEQCNGNM LCFAPDLVIN
     KERMKLPFMT DQCEQMLKIC NEFVRLQVSY DEYLCMKVLL LLSTVPKDGL KSQAVFDEIR
     MTYIKELGKA IVKREENASQ NWQRFYQLTK LLDSMQEMVE GLLQICFYTF VNKTLSVEFP
     EMLAEIITNQ IPKFKDGSVK PLLFHQK
//