Swiss-Prot entry

ID   ESR2_SPAAU     STANDARD;      PRT;   559 AA.
AC   Q9W6M2;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Estrogen receptor beta (ER-beta).
GN   Name=ESR2; Synonyms=NR3A2;
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; 
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; 
OC   Sparidae; Sparus. 
OX   NCBI_TaxID=8175;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary;
RX   MEDLINE=21060884; PubMed=10927619 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Socorro S., Power D.M., Olsson P.-E., Canario A.V.M.;
RT   "Two estrogen receptors expressed in the teleost fish, Sparus aurata:
RT   cDNA cloning, characterization and tissue distribution.";
RL   J. Endocrinol. 166:293-306(2000).
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-
CC       alpha, and activates expression of reporter genes containing
CC       estrogen response elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       alpha (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF136980; AAD31033.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P03372; 1ERR. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q9W6M2; 152-223.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PIRSF; PIRSF002527; ER-ab; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9W6M2.
DR   ProtoNet; Q9W6M2.
DR   ProtoMap; Q9W6M2.
DR   PRESAGE; Q9W6M2.
DR   DIP; Q9W6M2.
DR   ModBase; Q9W6M2.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DOMAIN        1    155       Modulating.
FT   DNA_BIND    156    221       Nuclear receptor-type.
FT   ZN_FING     156    176       C4-type.
FT   ZN_FING     192    216       C4-type.
FT   DOMAIN      222    559       Steroid-binding.
SQ   SEQUENCE   559 AA;  62698 MW;  65612384B71DF76D CRC64;
     MAVACSPEKD QSLLQLQKVD SSRVILSPVL SSPMETNQPI CIPSPYTDRG HDFPTIPFYS
     ATNFSYANPP AISDRPSVHQ TLSPSLFWPS HGHVGTTLPL HHLQARPQHG QAVQSPWVEL
     SPLDNVLTSS KSARRRSQEN EEGEVSSGGK ADLHFCAVCH DYASGYHYGV WSCEGCKAFF
     KRSIQRHNDY ICPATNQCTI DKNRRKSCQA CRLHKCYNVG MTKCGMRKER GNFRDPQMRR
     VTRLSSQGRT SGPSVLNGPA VGPLNTPQPP ALTSKQLIER IMEAEPPEIY LMKDMRRPLT
     EANIMMSLTN LADKELVHMI TWAKKIPGFL ELGLLDQVHL LECCWLEVLM IGLMWRSVDH
     PGKLIFSPDL SLSREEGSCV QGFLEIFDML IAATSRVREL KLQREEYVCL KAMILLNSNM
     CLSSSEGSEE LQSRSKLLRL LDAVTDALVW AIAKTGLTFR QQYTRLAHLL MLLSHIRHVS
     NKGMDHLHGM KMKNMVPLYD LLLEMLDAHI MHSSRLPRRS PQQETVEQCD APARPHSPGT
     SGPTNTWTPS CTGGRGEPQ
//