Swiss-Prot entry
ID ESR2_RAT STANDARD; PRT; 530 AA.
AC Q62986; O35784; O35785; O55015; O55016; O70195; Q9R185;
DT 15-JUL-1999 (Rel. 38, Created)
DT 15-JUL-1999 (Rel. 38, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Estrogen receptor beta (ER-beta).
GN Name=Esr2; Synonyms=Erbeta, Nr3a2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE OF 46-530 (ISOFORM 1).
RC STRAIN=Sprague-Dawley; TISSUE=Prostate;
RX MEDLINE=96234066; PubMed=8650195 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.93.12.5925;
RA Kuiper G.G.J.M., Enmark E., Pelto-Huikko M., Nilsson S.,
RA Gustafsson J.-A.;
RT "Cloning of a novel receptor expressed in rat prostate and ovary.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:5925-5930(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 46-530 (ISOFORM 2).
RC STRAIN=Wistar; TISSUE=Ovary;
RX MEDLINE=98262932; PubMed=9600083 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1006/bbrc.1998.8590;
RA Maruyama K., Endoh H., Sasaki-Iwaoka H., Kanou H., Shimaya E.,
RA Hashimoto S., Kato S., Kawashima H.;
RT "A novel isoform of rat estrogen receptor beta with 18 amino acid
RT insertion in the ligand binding domain as a putative dominant negative
RT regular of estrogen action.";
RL Biochem. Biophys. Res. Commun. 246:142-147(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 2).
RC STRAIN=Wistar; TISSUE=Prostate;
RA Aldridge T.C.;
RT "Tissue specific responses to estrogen: an explanation based on
RT differential activation of multiple estrogen receptors with different
RT estrogen response elements.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE OF 46-530 (ISOFORMS 1; 3 AND 4).
RC STRAIN=Sprague-Dawley;
RX MEDLINE=98151005; PubMed=9492041 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/en.139.3.1082;
RA Petersen D.N., Tkalcevic G.T., Koza-Taylor P.H., Turi T.G.,
RA Brown T.A.;
RT "Identification of estrogen receptor beta2, a functional variant of
RT estrogen receptor beta expressed in normal rat tissues.";
RL Endocrinology 139:1082-1092(1998).
RN [5]
RP PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 5).
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Price R., Handa R.J.;
RT "A novel splice variant of estrogen receptor beta found in rat
RT brain.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH UBE1C.
RX PubMed=11818503 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1210/me.16.2.315;
RA Fan M., Long X., Bailey J.A., Reed C.A., Osborne E., Gize E.A.,
RA Kirk E.A., Bigsby R.M., Nephew K.P.;
RT "The activating enzyme of NEDD8 inhibits steroid receptor function.";
RL Mol. Endocrinol. 16:315-330(2002).
CC -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-
CC alpha, and activates expression of reporter genes containing
CC estrogen response elements (ERE) in an estrogen-dependent manner.
CC Isoform 3 and isoform 4 are unable to bind DNA and activate
CC transcription due to the truncation of the DNA binding domain.
CC Isoform 2 shows loss of ligand binding affinity and suppresses ER-
CC alpha and ER-beta1 mediated transcriptional activation and may act
CC as a dominant negative regulator of estrogen action.
CC -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with
CC ESR1. Can also form heterodimers between isoform 1 and isoform 2.
CC Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a
CC strong increase of transcription of target genes (By similarity).
CC Binds UBE1C.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=Additional isoforms seem to exist;
CC Name=1; Synonyms=Beta1;
CC IsoId=Q62986-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta2;
CC IsoId=Q62986-2; Sequence=VSP_003699;
CC Name=3; Synonyms=Beta1-delta3;
CC IsoId=Q62986-3; Sequence=VSP_003697;
CC Name=4; Synonyms=Beta2-delta3;
CC IsoId=Q62986-4; Sequence=VSP_003697, VSP_003699;
CC Name=5; Synonyms=Beta1-delta4;
CC IsoId=Q62986-5; Sequence=VSP_003698;
CC -!- TISSUE SPECIFICITY: Expressed in prostate, ovary, lung, liver,
CC kidney, fat, bone, brain, uterus and testis.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; U57439; AAC52602.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AB012721; BAA25431.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ002602; CAA05631.1; ALT_INIT. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ002603; CAA05632.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF042058; AAB97424.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF042059; AAB97425.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF042060; AAB97426.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF042061; AAB97427.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF161187; AAD47637.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PDB; 1HJ1; X-ray; A=255-509. [ExPASy / RCSB]
DR PDB; 1QKN; X-ray; A=255-509. [ExPASy / RCSB]
DR SMR; Q62986; 144-216.
DR Ensembl; ENSRNOG00000005343; Rattus_norvegicus
DR RGD; 2582; Esr2.
DR GO; GO:0005634; C:nucleus; ISS.
DR GO; GO:0030284; F:estrogen receptor activity; TAS.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; ISS.
DR GO; GO:0048019; F:receptor antagonist activity; ISS.
DR GO; GO:0005496; F:steroid binding; ISS.
DR GO; GO:0030528; F:transcription regulator activity; TAS.
DR GO; GO:0030520; P:estrogen receptor signaling pathway; TAS.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; ISS.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR000324; VitD_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PIRSF; PIRSF002527; ER-ab; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; Q62986.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q62986.
DR ProtoNet; Q62986.
DR ProtoMap; Q62986.
DR PRESAGE; Q62986.
DR DIP; Q62986.
DR ModBase; Q62986.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW 3D-structure; Alternative splicing; DNA-binding; Nuclear protein;
KW Phosphorylation; Receptor; Steroid-binding; Transcription;
KW Transcription regulation; Zinc-finger.
FT DOMAIN 1 148 Modulating.
FT DNA_BIND 149 214 Nuclear receptor-type.
FT ZN_FING 149 169 C4-type.
FT ZN_FING 185 209 C4-type.
FT DOMAIN 215 530 Steroid-binding.
FT MOD_RES 87 87 Phosphoserine (By similarity).
FT MOD_RES 488 488 Phosphotyrosine (By similarity).
FT VARSPLIC 179 217 Missing (in isoform 3 and isoform 4).
FT /FTId=VSP_003697.
FT VARSPLIC 219 318 Missing (in isoform 5).
FT /FTId=VSP_003698.
FT VARSPLIC 364 364 R -> RSSEDPHWHVAQMKSAAPR (in isoform 2
FT and isoform 4).
FT /FTId=VSP_003699.
FT CONFLICT 72 72 L -> Q (in Ref. 3 and 4).
FT CONFLICT 150 150 P -> A (in Ref. 3 and 4).
FT CONFLICT 165 165 S -> P (in Ref. 3; CAA05631).
FT CONFLICT 505 505 S -> P (in Ref. 3; CAA05631).
FT HELIX 265 275
FT STRAND 283 283
FT HELIX 291 315
FT TURN 317 318
FT HELIX 319 321
FT HELIX 324 347
FT TURN 348 349
FT TURN 351 352
FT STRAND 353 357
FT TURN 358 358
FT STRAND 359 363
FT HELIX 364 368
FT TURN 371 372
FT HELIX 374 389
FT TURN 390 391
FT HELIX 394 406
FT TURN 407 407
FT HELIX 416 442
FT TURN 443 444
FT HELIX 448 477
FT TURN 478 478
SQ SEQUENCE 530 AA; 59152 MW; 36F269D9FD773DA9 CRC64;
MEIKNSPSSL SSPASYNCSQ SILPLEHGPI YIPSSYVDNR HEYSAMTFYS PAVMNYSVPG
STSNLDGGPV RLSTSPNVLW PTSGHLSPLA THCQSSLLYA EPQKSPWCEA RSLEHTLPVN
RETLKRKLSG SSCASPVTSP NAKRDAHFCP VCSDYASGYH YGVWSCEGCK AFFKRSIQGH
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSSSEQVH
CLSKAKRNGG HAPRVKELLL STLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLASANQEA
ESSRKLTHLL NAVTDALVWV IAKSGISSQQ QSVRLANLLM LLSHVRHISN KGMEHLLSMK
CKNVVPVYDL LLEMLNAHTL RGYKSSISGS ECSSTEDSKN KESSQNLQSQ
//