Swiss-Prot entry

ID   ESR2_CHICK     STANDARD;      PRT;   472 AA.
AC   Q9PTU5;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Estrogen receptor beta (ER-beta) (cERb).
GN   Name=ESR2; Synonyms=NR3A2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; 
OC   Gallus. 
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=White leghorn; TISSUE=Testis;
RA   Suzuki M., Mizuno S., Nakabayashi O.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-
CC       alpha, and activates expression of reporter genes containing
CC       estrogen response elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       alpha.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AB036415; BAA88667.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q9UHD3; 1L2J. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q9PTU5; 100-172, 213-451.
DR   Ensembl; ENSGALG00000011801; Gallus_gallus
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PIRSF; PIRSF002527; ER-ab; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9PTU5.
DR   ProtoNet; Q9PTU5.
DR   ProtoMap; Q9PTU5.
DR   PRESAGE; Q9PTU5.
DR   DIP; Q9PTU5.
DR   ModBase; Q9PTU5.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   DOMAIN        1    104       Modulating.
FT   DNA_BIND    105    170       Nuclear receptor-type.
FT   ZN_FING     105    125       C4-type.
FT   ZN_FING     141    165       C4-type.
FT   DOMAIN      171    472       Steroid-binding.
SQ   SEQUENCE   472 AA;  53439 MW;  A8CBBB8CACA65650 CRC64;
     MAFCSPAMLN YNIASNFGDS ESASVRQTSS PSVLWSAPGH LSPLTLHCQS SLLYAEQPKS
     PWCEVRPLDP VLPVTRETLK RKTNGSDCTS PIASNPGSKR DAHFCAVCSD YASGYHYGVW
     SCEGCKAFFK RSIQGHNDYI CPATNQCTID KNRRKSCQAC RLRKCYEVGM MKCGSRRERC
     GYRILRRHRN SEDCMGKTKK YNEAATRVKE ILLSTVSPEQ FVLTLLEAEP PNVLVSRPSK
     PFTEASMMMS LTKLADKELV HMIGWAKKIP GFIDLSLYDQ VRLLESCWME VLMIGLMWRS
     IDHPGKLIFA PDLVLDRDEG KCVEGILEIF DMLLAMTSRF RELKLQHKEY LCVKAMILLN
     SSMFPLSPEE PESNRKLHHL LNVVTDALVW VIAKSGIPSQ QQTTRLANLL MLLSHVRHAS
     NKGMEHLLSM KCKNVVPVYD LLLEMLNAHT LRGQRKSPVT HPEFEQVSHF QV
//