Swiss-Prot entry

ID   ESR1_SHEEP     STANDARD;      PRT;   111 AA.
AC   P49885;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Estrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Fragment).
GN   Name=ESR1; Synonyms=ESR, NR3A1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; 
OC   Pecora; Bovidae; Caprinae; Ovis. 
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=96432314; PubMed=8835380 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Ing N.H., Spencer T.E., Bazer F.W.;
RT   "Estrogen enhances endometrial estrogen receptor gene expression by a
RT   posttranscriptional mechanism in the ovariectomized ewe.";
RL   Biol. Reprod. 54:591-599(1996).
CC   -!- FUNCTION: Nuclear hormone receptor. The steroid hormones and their
CC       receptors are involved in the regulation of eukaryotic gene
CC       expression and affect cellular proliferation and differentiation
CC       in target tissues.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with
CC       ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading
CC       to a strong increase of transcription of target genes. Binds UBE1C
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; U30299; AAB52517.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P03372; 1HCQ. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P49885; 45-111.
DR   InterPro; IPR001292; Oestrgn_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF02159; Oest_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P49885.
DR   ProtoNet; P49885.
DR   ProtoMap; P49885.
DR   PRESAGE; P49885.
DR   DIP; P49885.
DR   ModBase; P49885.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   NON_TER       1      1
FT   DOMAIN       <1     49       Modulating.
FT   DNA_BIND     50   >111       Nuclear receptor-type.
FT   ZN_FING      50     70       C4-type.
FT   ZN_FING      86    110       C4-type.
FT   NON_TER     111    111
SQ   SEQUENCE   111 AA;  12527 MW;  FA5C1443A8320ECE CRC64;
     PSGYAVREAG PPAYYRPNSD NRRQGGRERL ASTSDKGSMA VESAKETRYC AVCNDYASGY
     HYGVWSCEGC KAFFKRSIQG HNDYMCPATN QCTIDKNRRK SCQACRLRKC Y
//