Swiss-Prot entry

ID   ESR1_SALSA     STANDARD;      PRT;   535 AA.
AC   P50242;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Estrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Fragment).
GN   Name=ESR1; Synonyms=ESR, NR3A1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; 
OC   Protacanthopterygii; Salmoniformes; Salmonidae; Salmo. 
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC   TISSUE=Liver;
RX   MEDLINE=20362504; PubMed=10818271 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0305-0491(99)00184-4;
RA   Rogers S.A., Llewellyn L., Wigham T., Sweeney G.E.;
RT   "Cloning of the Atlantic salmon (Salmo salar) estrogen receptor-alpha
RT   gene.";
RL   Comp. Biochem. Physiol. 125B:379-385(2000).
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in
CC       the regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       beta (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Highest expression in brain and liver.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X89959; CAA61999.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; S58224; S58224.
DR   HSSP; P03372; 1UOM. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P50242; 101-172.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P50242.
DR   ProtoNet; P50242.
DR   ProtoMap; P50242.
DR   PRESAGE; P50242.
DR   DIP; P50242.
DR   ModBase; P50242.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   NON_TER       1      1
FT   DOMAIN       <1    104       Modulating (Potential).
FT   DNA_BIND    105    170       Nuclear receptor-type.
FT   ZN_FING     105    125       C4-type.
FT   ZN_FING     141    165       C4-type.
FT   DOMAIN      171    236       Hinge.
FT   DOMAIN      237    535       Steroid-binding (Potential).
SQ   SEQUENCE   535 AA;  58900 MW;  669F13D7B243B612 CRC64;
     SRMLTDPPRI GSMQSLGSSP TGPLVFVSSS PQLSPFLHPP GHHGLPSQSY YLETSSTPLY
     RSSVVTNQLS ASEEKLCITS NRQQSYAAAG SGVRVFEMAN ETRYCAVCSD FASGYHYGFW
     SCEGCKAFFK RSIQGHNDYM CPATNQCTMD RNRRKSCQAC RLRKCYEVGM VKGGLRKDRG
     GRVLRKDKRY CGPAGDREKP YGDLEHRTAP PQDGGRNSSS SSLSGGGGWC GPRITMPPEQ
     VLFLLQGAEP PALCSRQKVA RPYTEVTMMT LLTSMADKEL VHMIAWAKKV PGFQELSLHD
     QVQLLESSWL EVLMIGLIWR SIHCPGKLIF AQDLILDRSE GDCVEGMAEI FDMLLATVSR
     FRMLKLKPEE FVCLKAIILL NSGAFSFCSN SVESLHNSSA VESMLDNITD ALIHHISHSG
     ASVQQQPRRQ VQLLLLLSHI RHMSNKGMEH LYSIKCKNKV PLYDLLLEML DGHRLQSPGK
     VAQAGEQTEG PSTTTTTSTG SSIGPMRGSQ DTHIRSPGSG VLQYGSPSSD QMPIP
//