Swiss-Prot entry

ID   ESR1_MICUN     STANDARD;      PRT;   525 AA.
AC   P57753;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Estrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Fragment).
GN   Name=ESR1; Synonyms=ESR, NR3A1;
OS   Micropogonias undulatus (Atlantic croaker).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; 
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; 
OC   Sciaenidae; Micropogonias. 
OX   NCBI_TaxID=29154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver;
RX   MEDLINE=20461442; PubMed=11005855 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.97.20.10751;
RA   Hawkins M.B., Thornton J.W., Crews D., Skipper J.K., Dotte A.,
RA   Thomas P.;
RT   "Identification of a third distinct estrogen receptor and
RT   reclassification of estrogen receptors in teleosts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:10751-10756(2000).
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in
CC       the regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       beta (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Abundant in the liver, less abundant in the
CC       testes and barely detectable in the ovary and brain.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF298183; AAG16713.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P03372; 1ERR. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P57753; 78-150.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR000324; VitD_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; PARTIAL.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P57753.
DR   ProtoNet; P57753.
DR   ProtoMap; P57753.
DR   PRESAGE; P57753.
DR   DIP; P57753.
DR   ModBase; P57753.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc-finger.
FT   NON_TER       1      1
FT   DOMAIN       <1     82       Modulating.
FT   DNA_BIND     83    148       Nuclear receptor-type.
FT   ZN_FING      83    103       C4-type.
FT   ZN_FING     119    143       C4-type.
FT   DOMAIN      149    209       Hinge.
FT   DOMAIN      210    525       Steroid-binding.
FT   DOMAIN      192    197       Poly-Ser.
SQ   SEQUENCE   525 AA;  57638 MW;  2DD254E5083707C7 CRC64;
     PTSPLVFVPS SPRLSPFMHP PSHHYLETTS TPVYRSSVSS SQQQLSREDQ CGTSDDSYSV
     GESGAGAGAG AGGFEMAKEM RFCAVCSDYA SGYDYGVWSC EGCKAFFKRS IQGHNDYMCP
     ATNQCTIDRN RRKSCQACRL RKCYQVGMMK GGVRKDRGRV LRRDKRRTGT SDKASKDLEH
     RTAPPQDRRK HSSSSSSAGG GGKSSIIGMS PDQVLLLLQG AEPPVLCSRQ KLSRPYTEVT
     MMTLLTSMAD KELVHMIAWA KKLPGFLQLS LHDQVQLLES SWLEVLMIGL IWRSIHCPGK
     LIFAQDLILD RSEGDCVEGM AEIFDMLLAT TSRFRMLKLK TEEFVCLKAI ILLNSGAFSF
     CTGTMEPLHD GAAVQNMLDT ITDALIHHIS QSGCSAQQQS RRQAHLLLLL SHIRHMSNKG
     MEHLYSMKCK NKVPLYDLLL EMLDAHRIHR PDRPAESWSQ ADREPPYTTS NNNNSSSSSG
     GGDGGPSSAG SGSGPRVNHE SLSRAPTGPG VLQYGGPRSD CTHIL
//