Swiss-Prot entry

ID   ECR_MANSE      STANDARD;      PRT;   556 AA.
AC   P49883;
DT   01-OCT-1996 (Rel. 34, Created)
DT   01-OCT-1996 (Rel. 34, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Ecdysone receptor (Ecdysteroid receptor) (20-hydroxy-ecdysone
DE   receptor) (20E receptor) (EcRH).
GN   Name=EcR; Synonyms=NR1H1;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; 
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Sphingoidea; 
OC   Sphingidae; Sphinginae; Manduca. 
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=95360028; PubMed=7633469 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0965-1748(95)00023-O;
RA   Fujiwara H., Jindra M., Newitt R., Palli S.R., Hiruma K.,
RA   Riddiford L.M.;
RT   "Cloning of an ecdysone receptor homolog from Manduca sexta and the
RT   developmental profile of its mRNA in wings.";
RL   Insect Biochem. Mol. Biol. 25:845-856(1995).
CC   -!- FUNCTION: Receptor for ecdysone. Binds to ecdysone response
CC       elements (ECRES).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: It is found in both larval wing disks and
CC       pupal wings and in prothoracic glands.
CC   -!- DEVELOPMENTAL STAGE: In the wing disks levels increase on day 2
CC       fifth larval instar reaching a maximum on day 5, and then decrease
CC       sharply on day 6. In the prothoracic glands levels increase
CC       sharply on day 2 then remain high throughout the larval-pupal
CC       transformation and after pupal ecdysis.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U19812; AAA86699.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P20393; 1A6Y. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P49883; 145-230, 287-530.
DR   InterPro; IPR000536; Hrmon_recept_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01283; ECDYSTEROIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   BLOCKS; P49883.
DR   ProtoNet; P49883.
DR   ProtoMap; P49883.
DR   PRESAGE; P49883.
DR   DIP; P49883.
DR   ModBase; P49883.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   DNA-binding; Nuclear protein; Receptor; Transcription;
KW   Transcription regulation; Zinc-finger.
FT   DOMAIN        1    146       Modulating (Potential).
FT   DNA_BIND    147    219       Nuclear receptor-type.
FT   ZN_FING     147    167       C4-type.
FT   ZN_FING     183    207       C4-type.
FT   DOMAIN      305    528       Hormone-binding (Potential).
FT   DOMAIN       75     84       Poly-Gln.
FT   DOMAIN      258    261       Poly-Pro.
FT   DOMAIN      326    332       Poly-Glu.
SQ   SEQUENCE   556 AA;  62830 MW;  9AF83AA33D551EB1 CRC64;
     MRRRWSNNGC FPLRMFEESS SEVTSSSAFG MPAAMVMSPE SLASPEYGGL ELWSYDETMT
     NYPAQSLLGA CNAPQQQQQQ QQQQPSAQPL PSMPLPMPPT TPKSENESMS SGREELSPAS
     SINGCSTDGE PRRQKKGPAP RQQEELCLVC GDRASGYHYN ALTCEGCKGF FRRSVTKNAV
     YICKFGHACE MDMYMRRKCQ ECRLKKCLAV GMRPECVVPE STCKNKRREK EAQREKDKLP
     VSTTTVDDHM PAIMQCDPPP PEAARIHEVV PRFLTEKLME QNRLKNVTPL SANQKSLIAR
     LVWYQEGYEQ PSEEDLKRVT QTWQLEEEEE EETDMPFRQI TEMTILTVQL IVEFAKGLPG
     FSKISQSDQI TLLKASSSEV MMLRVARRYD AATDSVLFAN NQAYTRDNYR KAGMSYVIED
     LLHFCRCMYS MSMDNVHYAL LTAIVIFSDR PGLEQPLLVE EIQRYYLKTL RVYILNQHSA
     SPRCAVLFGK ILGVLTELRT LGTQNSNMCI SLKLKNRKLP PFLEEIWDVA EVSTTQPTPG
     VAAQVTPIVV DNPAAL
//