Swiss-Prot entry
ID E75B_DROME STANDARD; PRT; 1394 AA.
AC P17672;
DT 01-AUG-1990 (Rel. 15, Created)
DT 01-AUG-1990 (Rel. 15, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Ecdysone-induced protein 75B isoform B (E75-B).
GN Name=Eip75B; Synonyms=NR1D3;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING.
RC STRAIN=Canton-S;
RX MEDLINE=90249727; PubMed=2110921 [NCBI, ExPASy, EBI, Israel, Japan];
RA Segraves W.A., Hogness D.S.;
RT "The E75 ecdysone-inducible gene responsible for the 75B early puff in
RT Drosophila encodes two new members of the steroid receptor
RT superfamily.";
RL Genes Dev. 4:204-219(1990).
RN [2]
RP DEVELOPMENTAL STAGE.
RX MEDLINE=94038699; PubMed=8223281 [NCBI, ExPASy, EBI, Israel, Japan];
RA Huet F., Ruiz C., Richards G.;
RT "Puffs and PCR: the in vivo dynamics of early gene expression during
RT ecdysone responses in Drosophila.";
RL Development 118:613-627(1993).
CC -!- FUNCTION: Implicated in the regulation of ecdysone-triggered gene
CC hierarchies. Probably plays a key role in mediating the regulation
CC of the larval molt by 20-OH-ecdysone.
CC -!- SUBCELLULAR LOCATION: Nuclear (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=B; Synonyms=E75B;
CC IsoId=P17672-1; Sequence=Displayed;
CC Name=A; Synonyms=E75A;
CC IsoId=P17671-1; Sequence=External;
CC Name=C; Synonyms=E75C;
CC IsoId=P13055-2; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: In mid instar larvae salivary glands, levels
CC are low during puff stage 1, increase during puff stages 2-4 and
CC diminish from stage 5 onwards. In prepupae, isoform B is the
CC predominant form during puff stage 19 and the transition to stage
CC 20. By stage 3 it is present in the gut, Malpighian tubules and
CC the fat body, levels persist beyond stage 11.
CC -!- INDUCTION: The expression of this protein is developmentally
CC regulated and is correlated with the 20-OH-ecdysone induced
CC activity of puff 75B.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; X51549; CAA35924.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; B34598; B34598.
DR HSSP; P20393; 1A6Y. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; P17672; 415-480.
DR TRANSFAC; T01368; -.
DR FlyBase; FBgn0000568; Eip75B.
DR GO; GO:0004879; F:ligand-dependent nuclear receptor activity; NAS.
DR GO; GO:0018990; P:ecdysis (sensu Insecta); IMP.
DR GO; GO:0035072; P:ecdysone-mediated induction of salivary gla...; NAS.
DR GO; GO:0007553; P:regulation of ecdysteroid metabolism; IMP.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001728; ThyrH_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P17672.
DR BLOCKS; P17672.
DR ProtoNet; P17672.
DR ProtoMap; P17672.
DR PRESAGE; P17672.
DR DIP; P17672.
DR ModBase; P17672.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; Developmental protein; DNA-binding;
KW Metal-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT DOMAIN 12 21 Poly-Gln.
FT DOMAIN 24 31 Poly-Gln.
FT DOMAIN 104 107 Poly-Gln.
FT DOMAIN 116 123 Poly-Gln.
FT DOMAIN 135 139 Poly-Gln.
FT DOMAIN 147 150 Poly-Thr.
FT DOMAIN 166 172 Poly-Gln.
FT DOMAIN 181 184 Poly-Ala.
FT DOMAIN 300 306 Poly-Gln.
FT DOMAIN 311 325 Poly-Gln.
FT DNA_BIND 385 475 Nuclear receptor-type.
FT DOMAIN 878 886 Poly-Gln.
FT DOMAIN 906 910 Poly-Gln.
FT DOMAIN 1164 1169 Poly-Ser.
FT DOMAIN 1206 1225 Poly-Ser.
FT DOMAIN 1228 1234 Poly-Ser.
FT DOMAIN 1253 1260 Poly-Ser.
SQ SEQUENCE 1394 AA; 152097 MW; 45CACF77BDE9FB80 CRC64;
MVCAMQEVAA VQHQQQQQQL QLPQQQQQQQ QTTQQQHATT IVLLTGNGGG NLHIVATPQQ
HQPMHQLHHQ HQHQHQHQQQ AKSQQLKQQH SALVKLLESA PIKQQQQTPK QIVYLQQQQQ
QPQRKRLKNE AAIVQQQQQT PATLVKTTTT SNSNSNNTQT TNSISQQQQQ HQIVLQHQQP
AAAATPKPCA DLSAKNDSES GIDEDCPNSD EDCPNANPAG TSLEDSSYEQ YQCPWKKIRY
ARELLKQREL EQQQTTGGSN AQQQVEAKPA AIPTSNIKQL HCDSPFSAQT HKEIANLLRQ
QSQQQQVVAT QQQQQQQQQH QHQQQRRDSS DSNCSLMSNS SNSSAGNCCT CNAGDDQQLE
EMDEAHDSGC DDELCEQHHQ RLDSSQLNYL CQKFDEKLDT ALSNSSANTG RNTPAVTANE
DADGFFRRSI QQKIQYRPCT KNQQCSILRI NRNRCQYCRL KKCIAVGMSR DAVRFGRVPK
REKARILAAM QQSTQNRGQQ RALATELDDQ PRLLAAVLRA HLETCEFTKE KVSAMRQRAR
DCPSYSMPTL LACPLNPAPE LQSEQEFSQR FAHVIRGVID FAGMIPGFQL LTQDDKFTLL
KAGLFDALFV RLICMFDSSI NSIICLNGQV MRRDAIQNGA NARFLVDSTF NFAERMNSMN
LTDAEIGLFC AIVLITPDRP GLRNLELIEK MYSRLKGCLQ YIVAQNRPDQ PEFLAKLLET
MPDLRTLSTL HTEKLVVFRT EHKELLRQQM WSMEDGNNSD GQQNKSPSGS WADAMDVEAA
KSPLGSVSST ESADLDYGSP SSSQPQGVSL PSPPQQQPSA LASSAPLLAA TLSGGCPLRN
RANSGSSGDS GAAEMDIVGS HAHLTQNGLT ITPIVRHQQQ QQQQQQIGIL NNAHSRNLNG
GHAMCQQQQQ HPQLHHHLTA GAARYRKLDS PTDSGIESGN EKNECKAVSS GGSSSCSSPR
SSVDDALDCS DAAANHNQVV QHPQLSVVSV SPVRSPQPST SSHLKRQIVE DMPVLKRVLQ
APPLYDTNSL MDEAYKPHKK FRALRHREFE TAEADASSST SGSNSLSAGS PRQSPVPNSV
ATPPPSAASA AAGNPAQSQL HMHLTRSSPK ASMASSHSVL AKSLMAEPRM TPEQMKRSDI
IQNYLKRENS TAASSTTNGV GNRSPSSSST PPPSAVQNQQ RWGSSSVITT TCQQRQQSVS
PHSNGSSSSS SSSSSSSSSS SSTSSNCSSS SASSCQYFQS PHSTSNGTSA PASSSSGSNS
ATPLLELQVD IADSAQPLNL SKKSPTPPPS KLHALVAAAN AVQRYPTLSA DVTVTASNGG
SSVGGGESGR QQQSAGECGL PQSGPERRRA QGNAGGVRAG GGRWFYAEKW ERQRLGVAVQ
RSRKQDHLER RELN
//