Swiss-Prot entry
ID COT2_CHICK STANDARD; PRT; 410 AA.
AC Q90733;
DT 15-DEC-1998 (Rel. 37, Created)
DT 15-DEC-1998 (Rel. 37, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE COUP transcription factor 2 (COUP-TF2) (COUP-TF II).
GN Name=NR2F2; Synonyms=TFCOUP2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae;
OC Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=94163976; PubMed=8119130 [NCBI, ExPASy, EBI, Israel, Japan];
RA Lutz B., Kuratani S., Cooney A.J., Wawersik W., Tsai S.Y., Eichele G.,
RA Tsai M.;
RT "Developmental regulation of the orphan receptor COUP-TF II gene in
RT spinal motor neurons.";
RL Development 120:25-36(1994).
CC -!- FUNCTION: May be involved in motor neuron development.
CC -!- SUBUNIT: Binds DNA as a homodimer.
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- TISSUE SPECIFICITY: Highly expressed in the developing spinal
CC motor neurons.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
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DR EMBL; U00697; AAA17733.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; I50689; I50689.
DR HSSP; P19793; 1BY4. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR Ensembl; ENSGALG00000007000; Gallus_gallus
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR001723; Stdhrmn_receptor.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01282; COUPTNFACTOR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q90733.
DR ProtoNet; Q90733.
DR ProtoMap; Q90733.
DR PRESAGE; Q90733.
DR DIP; Q90733.
DR ModBase; Q90733.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Transcription;
KW Transcription regulation; Zinc-finger.
FT DOMAIN 67 71 Poly-Gln.
FT DNA_BIND 72 147 Nuclear receptor-type.
FT ZN_FING 75 95 C4-type.
FT ZN_FING 111 135 C4-type.
FT DOMAIN 333 410 Important for dimerization.
SQ SEQUENCE 410 AA; 45427 MW; 760A996E29082E3D CRC64;
MAMVVGAWRD PQDDVPGAQG TQPAPAPPVQ GPPAGTPHTP QTPGPGGPPS TPAQSNAASQ
QSQGDKQQQQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLSYT CRANRNCPID
QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPTHGQF ALTNGDPLNC HSYLSGYISL
LLRAEPYPTS RFGSQCMQPN NIMGIENICE LAARMLFSAV EWARNIPFFP DLQITDQVAL
LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI FQEQVEKLKA
LHVDSAEYSC LKAIVLFTSD ACGLSDVAHV ESLQEKSQCA LEEYVRSQYP NQPTRFGKLL
LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ
//