Swiss-Prot entry
ID ANDR_MOUSE STANDARD; PRT; 899 AA.
AC P19091;
DT 01-NOV-1990 (Rel. 16, Created)
DT 01-NOV-1990 (Rel. 16, Last sequence update)
DT 01-MAY-2005 (Rel. 47, Last annotation update)
DE Androgen receptor (Dihydrotestosterone receptor).
GN Name=Ar; Synonyms=Nr3c4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/c;
RX MEDLINE=90386642; PubMed=2403358 [NCBI, ExPASy, EBI, Israel, Japan];
RA He W.W., Fischer L.M., Sun S., Bilhartz D.L., Zhu X., Young C.Y.F.,
RA Kelley D.B., Tindall D.J.;
RT "Molecular cloning of androgen receptors from divergent species with a
RT polymerase chain reaction technique: complete cDNA sequence of the
RT mouse androgen receptor and isolation of androgen receptor cDNA probes
RT from dog, guinea pig and clawed frog.";
RL Biochem. Biophys. Res. Commun. 171:697-704(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=91133433; PubMed=2178222 [NCBI, ExPASy, EBI, Israel, Japan];
RA Gaspar M.L., Meo T., Tosi M.;
RT "Structure and size distribution of the androgen receptor mRNA in
RT wild-type and Tfm/Y mutant mice.";
RL Mol. Endocrinol. 4:1600-1610(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=91354214; PubMed=1883336 [NCBI, ExPASy, EBI, Israel, Japan];
RA Faber P.W., King A., van Rooij H.C.J., Brinkmann A.O., de Both N.J.,
RA Trapman J.;
RT "The mouse androgen receptor. Functional analysis of the protein and
RT characterization of the gene.";
RL Biochem. J. 278:269-278(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92017874; PubMed=1681426 [NCBI, ExPASy, EBI, Israel, Japan];
RA Charest N.J., Zhou Z., Lubahn D.B., Olsen K.L., Wilson E.M.,
RA French F.S.;
RT "A frameshift mutation destabilizes androgen receptor messenger RNA in
RT the Tfm mouse.";
RL Mol. Endocrinol. 5:573-581(1991).
CC -!- FUNCTION: The steroid hormones and their receptors are involved in
CC the regulation of eukaryotic gene expression and affect cellular
CC proliferation and differentiation in target tissues. Activated,
CC but not phosphorylated, by HIPK3.
CC -!- SUBUNIT: Binds DNA as a homodimer. The AR N-terminal poly-Gln
CC region binds Ran resulting in enhancement of AR-mediated
CC transactivation. Ran-binding decreases as the poly-Gln length
CC increases. Interacts with RANBP9. Interacts with HIPK3 in the
CC presence of androgen (By similarity).
CC -!- SUBCELLULAR LOCATION: Nuclear.
CC -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC a DNA-binding domain and a C-terminal steroid-binding domain.
CC Interaction with RANBP9 is mediated by both the N-terminal domain
CC and the DNA-binding domain (By similarity).
CC -!- MISCELLANEOUS: In the absence of ligand, steroid hormone receptors
CC are thought to be weakly associated with nuclear components;
CC hormone binding greatly increases receptor affinity. The hormone-
CC receptor complex appears to recognize discrete DNA sequences
CC upstream of transcriptional start sites.
CC -!- MISCELLANEOUS: Transcriptional activity is enhanced by binding to
CC RANBP9.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily.
CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; S56585; AAB19916.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X53779; CAA37795.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M37890; AAA37234.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X59592; CAA42160.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; A35895; A35895.
DR HSSP; P10275; 1E3G. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; P19091; 535-608, 649-898.
DR TRANSFAC; T00041; -.
DR Ensembl; ENSMUSG00000046532; Mus_musculus
DR MGD; MGI:88064; Ar.
DR GeneLynx; Ar..
DR SOURCE; Ar..
DR GO; GO:0005737; C:cytoplasm; IDA.
DR GO; GO:0005634; C:nucleus; IDA.
DR GO; GO:0005515; F:protein binding; IPI.
DR GO; GO:0003700; F:transcription factor activity; IDA.
DR GO; GO:0008151; P:cell growth and/or maintenance; IDA.
DR GO; GO:0001701; P:embryonic development (sensu Mammalia); IMP.
DR GO; GO:0008584; P:male gonad development; IMP.
DR GO; GO:0045449; P:regulation of transcription; IDA.
DR InterPro; IPR001103; Andrgn_receptor.
DR InterPro; IPR000536; Hrmon_recept_lig.
DR InterPro; IPR008946; Str_ncl_receptor.
DR InterPro; IPR001628; Znf_C4steroid.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF02166; Androgen_recep; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00521; ANDROGENR.
DR PRINTS; PR00047; STROIDFINGER.
DR ProDom; PD000035; Znf_C4steroid; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR CMR; P19091.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P19091.
DR ProtoNet; P19091.
DR ProtoMap; P19091.
DR PRESAGE; P19091.
DR DIP; P19091.
DR ModBase; P19091.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW DNA-binding; Nuclear protein; Receptor; Steroid-binding;
KW Transcription; Transcription regulation; Zinc-finger.
FT DOMAIN 1 537 Modulating (By similarity).
FT DNA_BIND 538 611 Nuclear receptor-type.
FT ZN_FING 539 559 C4-type.
FT DOMAIN 551 641 Interaction with HIPK3 (By similarity).
FT ZN_FING 575 599 C4-type.
FT DOMAIN 670 899 Ligand-binding.
FT DOMAIN 63 67 Poly-Arg.
FT DOMAIN 174 193 Poly-Gln.
FT DOMAIN 367 373 Poly-Pro.
FT DOMAIN 391 397 Poly-Ala.
FT DOMAIN 441 447 Poly-Gly.
SQ SEQUENCE 899 AA; 98194 MW; FD9EE07C07F7A568 CRC64;
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAANIAPP GACLQQRQET
SPRRRRRQQH TEDGSPQAHI RGPTGYLALE EEQQPSQQQA ASEGHPESSC LPEPGAATAP
GKGLPQQPPA PPDQDDSAAP STLSLLGPTF PGLSSCSADI KDILNEAGTM QLLQQQQQQQ
QHQQQHQQHQ QQQEVISEGS SARAREATGA PSSSKDSYLG GNSTISDSAK ELCKAVSVSM
GLGVEALEHL SPGEQLRGDC MYASLLGGPP AVRPTPCAPL PECKGLPLDE GPGKSTEETA
EYSSFKGGYA KGLEGESLGC SGSSEAGSSG TLEIPSSLSL YKSGALDEAA AYQNRDYYNF
PLALSGPPHP PPPTHPHARI KLENPLDYGS AWAAAAAQCR YGDLGSLHGG SVAGPSTGSP
PATTSSSWHT LFTAEEGQLY GPGGGGGSSS PSDAGPVAPY GYTRPPQGLT SQESDYSASE
VWYPGGVVNR VPYPSPNCVK SEMGPWMENY SGPYGDMRLD STRDHVLPID YYFPPQKTCL
ICGDEASGCH YGALTCGSCK VFFKRAAEGK QKYLCASRND CTIDKFRRKN CPSCRLRKCY
EAGMTLGARK LKKLGNLKLQ EEGENSNAGS PTEDPSQKMT VSHIEGYECQ PIFLNVLEAI
EPGVVCAGHD NNQPDSFAAL LSSLNELGER QLVHVVKWAK ALPGFRNLHV DDQMAVIQYS
WMGLMVFAMG WRSFTNVNSR MLYFAPDLVF NEYRMHKSRM YSQCVRMRHL SQEFGWLQIT
PQEFLCMKAL LLFSIIPVDG LKNQKFFDEL RMNYIKELDR IIACKRKNPT SCSRRFYQLT
KLLDSVQPIA RELHQFTFDL LIKSHMVSVD FPEMMAEIIS VQVPKILSGK VKPIYFHTQ
//