2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS MSANSDTGDHQEKLKHGLREIGAGLPDRHRRPIPARSRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDE
NR5A2_HUMAN MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDE
Q9UEC0_HUMAN MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDE
Q9QWM0_RAT MSASSITGDFQDFLKHGLPAIGAGLPDRHRRPIPARSRLVMLPKVETEASGLVRSHGEQGQMPENMQVSQFKMVNYSYDE
Q9QWM1_RAT APAPGSETPHSPKLEEKHREKRAGLPDRHRRPIPARSRLVMLPKVETEASGLVRSHGEQGQMPENMQVSQFKMVNYSYDE
NR5A2_MOUSE ASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRLVMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDE
NR5A2_CHICK ........................................MLPKVETEALGLARSNGEQGQMPENMQVSQFKMVNYSYDE
Q5XGE7_XENTR ........................................MLPKVEPEALGLSRSHGEQGHMPENMQASQFKMMGYSYDE
Q9IB82_RANRU ........................................MLPKVESEALGLSRSHGEHGQMPDNMQVSQFKMMGYSYDD
Q91544_XENLA ........................................MLPKVESEALGLSRLHGEQGHMPDNMQVSQYKMMGYSYDD
Q9GKL1_HORSE ........................................MSSNLDT...GDLRDSGKHGLTP...IVSQFKMVNYSYDE
Q90YL6_BRARE ........................................MLPKVESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDE
Q9IB81_RANRU ........................................................................MMGYSYDD
O42186_BRARE ........................................MLPKVESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDE
Q91601_XENLA ........................................MLPKVESEALGLSRLHGEQGHMPDNMQVSQYKMMGYSYDD
D010 D020 D030 D040 D050 D060
|=========|=========|=========|=========|=========|======
CONSENSUS DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
NR5A2_HUMAN DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q9UEC0_HUMAN DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q9QWM0_RAT DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADR
Q9QWM1_RAT DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADR
NR5A2_MOUSE DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADR !
NR5A2_CHICK DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q5XGE7_XENTR ELEEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q9IB82_RANRU DLEEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQTCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q91544_XENLA ELEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCPIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q9GKL1_HORSE DLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
Q90YL6_BRARE DLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADR
Q9IB81_RANRU DLEEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQTCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
O42186_BRARE DLDEMCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCQIDKTQRKRCPYCRFQKCLTVGMKLEAVRADR
Q91601_XENLA ELEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQSCPIDKTQRKRCPYCRFQKCLSVGMKLEAVRADR
CONSENSUS MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
NR5A2_HUMAN MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
Q9UEC0_HUMAN MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
Q9QWM0_RAT MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLT..SAIQNIHSASKGLPLSHVALPPTDYDRSPF
Q9QWM1_RAT MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLT..SAIQNIHSASKGLPLSHVALPPTDYDRSPF
NR5A2_MOUSE MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLT..SAIQNIHSASKGLPLSHVALPPTDYDRSPF
NR5A2_CHICK MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVIQAMPTDLTISSAIQNIHSASKGLPLNHTALPPTDYDRSPF
Q5XGE7_XENTR MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMGQVIQSIPTDLTISSAIQNIHSASKGLPLNHAALPPSDYDRSPF
Q9IB82_RANRU MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAIPTDLTISSAIQNIHSASKGLPLNHTALPPTDYDRSPF
Q91544_XENLA MRGGRNKFGPMYKRDRAIKQQKKALIRANGLKLEAIGQVIQSIPTDLTISSAIQNIHSASKGLHLNHAALPPSDYDRSPF
Q9GKL1_HORSE MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSELSISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
Q90YL6_BRARE MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLShaGLPPADFDRSPF
Q9IB81_RANRU MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAIPTDLTISSAIQNIHSASKGLPLNHTALPPTDYDRSPF
O42186_BRARE MRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVMQTVPADLTITSAIQNIHSASKGLPLShaGLPPADFDRSPF
Q91601_XENLA MRGGRNKFGPMYKRDRAIKQQKKALIRANGLKLEAIGQVIQSIPTDLTISSAIQNIHSASKGLHLNHAALPPSDYDRSPF
140 150
===|=========|======
CONSENSUS VTSPISMTMPPHGSLQGYQAYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQA
NR5A2_HUMAN VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQA
Q9UEC0_HUMAN VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDSYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQA
Q9QWM0_RAT VTSPISMTMPPHGSLHGYQPYGHFPNRAIKSEYPDPYSSSPESMMGYSYMDGYQTSSPASIPHLILELLKCEPDEPQVQA
Q9QWM1_RAT VTSPISMTMPPHGSLHGYQPYGHFPNRAIKSEYPDPYSSSPESMMGYSYMDGYQTSSPASIPHLILELLKCEPDEPQVQA
NR5A2_MOUSE VTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQA
NR5A2_CHICK VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDGYQTSSPASIPHLILELQKCEPDEPQVQA
Q5XGE7_XENTR VTSPISMAMPPHGSLQGYQAYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQSSSPSNIPHLIVELLKCEPDEPQVQG
Q9IB82_RANRU VTSPISMAMPPHGSLQSYQAYGHFPSRAIKSEYPDPYTSSPESLMGYSYMDSYQSSSPSNIPHLIVELLKCEPDEPQVQS
Q91544_XENLA VTSPISMAMPPHGSLQGYQSYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQSSSPSNIPHLIVELLKCEPDEPQVQG
Q9GKL1_HORSE VTSPISMTMPPHGSLQGYQTYSHFPSRAIKSEYPDPYTSSPESIMGYSYMDGYQTSSPASIPHLILELLKCEPDEPQVQA
Q90YL6_BRARE VTSPVSMAMPPhgGLQGYQAYGHFQSRTIKSEYPDPYTSSPESLMGYPYVEAYAGGSPPSFPHLVVELLKCEPDEPQVQA
Q9IB81_RANRU VTSPISMAMPPHGSLQSYQAYGHFPSRAIKSEYPDPYTSSPESLMGYSYMDSYQSSSPSNIPHLIVELLKCEPDEPQVQS
O42186_BRARE VTSPVSMAMPPhgGLQGYQAYGHFQSRTIKSEYPTP.TQARQSPHGLPLRRSLRSGSPPSFPHLVVELLKCEPDEPQVQA
Q91601_XENLA VTSPISMAMPPHGSLQGYQSYGHFPSRAIKSEYPDPYTSSPESIMGYSFMDSYQSSSPSNIPHLIVELLKCEPDEPQVQG
330 340 350 450 550 560
==|=========|=========|=== ===|==========|=========|
CONSENSUS KIMAYLQQEQANRSKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKE
NR5A2_HUMAN KIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKE
Q9UEC0_HUMAN KIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKE
Q9QWM0_RAT KIMAYLQQEQNNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKE
Q9QWM1_RAT KIMAYLQQEQNNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKE
NR5A2_MOUSE KIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKE
NR5A2_CHICK KIMAYLQQEQANRSKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHVKE
Q5XGE7_XENTR KIMAYLQQEQANRSKHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIFRQVLHGKE
Q9IB82_RANRU KIMSYLQQEQANRSKHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIFRQVLHGKE
Q91544_XENLA KIMAYLQQEQANRSKHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRDLKVDDQMKLLQNCWSELLILDHIFRQVLHGKE
Q9GKL1_HORSE KIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKE
Q90YL6_BRARE KILAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHVFRQVMHAKE
Q9IB81_RANRU KIMSYLQQEQANRSKHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIFRQVLHGKE
O42186_BRARE KILAYLQQEQASRGKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQKCWRELLILDHVFRQVMHAKE
Q91601_XENLA KIMAYLQQEQANRSKHDKLNTFGLMCKMADQTLFSIVEWARSSIFFRDLKKIK...........................
650 740 750 850 940
===|=== ====|=========|= ==|========= ====|=========
CONSENSUS GSILLVTGQQVDYSVIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
NR5A2_HUMAN GSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
Q9UEC0_HUMAN GSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
Q9QWM0_RAT GTIFLVTGEHVDYSSIISNTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENFQLVEGVQEQVNAA
Q9QWM1_RAT GTIFLVTGEHVDYSSIISNTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENFQLVEGVQEQVNAA
NR5A2_MOUSE GTIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAA
NR5A2_CHICK GSILLVTGQQVDYSVIASQAGATLNNLMSHAQELVAKLRSLQFDLREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
Q5XGE7_XENTR GSILLVTGQQVDYSVIVTQAGATLNNLMSHAQDLVAKLRSLQFDLREFVCLKFLVLFSLDVKNLENYQLVEGVQEQINAA
Q9IB82_RANRU GSILLVTGQQVDFSVIVSQAGTTLNNLMSHAQELVAKLRSLQFDMREFVCLKFLVLFSLDVKNLENFQLVEGVQEQINAA
Q91544_XENLA GSILLVTGQQVDYSVIVTQAGATLNNLMSHAQDLVAKLRSLQFDLREFVCLKFLVLFSLDVKTLENYQLVEGVQEQVNAA
Q9GKL1_HORSE GSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
Q90YL6_BRARE GSILLVTGQQVDYALIASQAGATLNNLLSHAQELVSKLRSLQLDQREFVCLKFLVLFSLDVKNLENFHLVESVQEQVNAA
Q9IB81_RANRU GSILLVTGQQVDFSVIVSQAGTTLNNLMSHAQELVAKLRSLQFDMREFVCLKFLVLFSLDVKNLENFQLVEGVQEQINAA
O42186_BRARE GSILLVTGQQVDYALIASQAGATLNNLLSHAQELVSKLRSLQLDQREFVCLKFLVLFSLDVKNLENFHLVESVQEQVNAA
Q91601_XENLA ................................................................................
950 1040 1050 1060 1250
|======== ==|=========|=========|= =====|==
CONSENSUS LLDYTMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA
NR5A2_HUMAN LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA...................
Q9UEC0_HUMAN LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA...................
Q9QWM0_RAT LLDYTLCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA...................
Q9QWM1_RAT LLDYTLCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA...................
NR5A2_MOUSE LLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA...................
NR5A2_CHICK LLDYTMCNYPQQTDKFGQLLLRLPEIRAISMQAEEYLYCKHLNGDVPCNNLLIEMLHAKRA...................
Q5XGE7_XENTR LLDYTMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
Q9IB82_RANRU LLDYTLCYYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
Q91544_XENLA LLDYTMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
Q9GKL1_HORSE LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA...................
Q90YL6_BRARE LLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
Q9IB81_RANRU LLDYTLCYYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
O42186_BRARE LLDYVMCNYPQQTDKFGQLLLRLPEIRAISLQAEEYLYYKHLNGDVPCNNLLIEMLHAKRA...................
Q91601_XENLA ................................................................................