2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS MPCVQAQYGSPPQSPGPRDHYSSDPLTPEFVKFTMDLASTEIAPTATTSLPSFSTFMDGYTGEFDTKPSCLYQMVQPCSS
NR4A1_HUMAN MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS
Q6IBU8_HUMAN MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS
Q6ZMM6_HUMAN MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS
Q8N3V2_HUMAN MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS
Q5RBB0_PONPY MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSS
NR4A1_CANFA MPCIQAQYGTPAPSPGPRDHLASDPLTPELSKPTMDLASPEAAPTAPTALPSFSTFMDGYTGEFDTFLYQLPGTAQPCSS
NR4A1_MOUSE MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAPAAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSS
NR4A2_MOUSE MPCVQAQYGSSPqsYHSSGEYSSDFLTPEFVKFSMDLTNTEI..TATTSLPSFSTFMDNYSTGYDVKPPCLYQM......
NR4A2_HUMAN MPCVQAQYGSSPqsYHSSGEYSSDFLTPEFVKFSMDLTNTEI..TATTSLPSFSTFMDNYSTGYDVKPPCLYQM......
NR4A2_RAT MPCVQAQYGSSPqsYHSSGEYSSDFLTPEFVKFSMDLTNTEI..TATTSLPSFSTFMDNYSTGYDVKPPCLYQM......
Q5R5Y4_PONPY MPCVQAQYGSSPqsYHSSGEYSSDFLTPEFVKFSMDLTNTEI..TATTSLPSFSTFMDNYSTGYDVKPPCLYQM......
NR4A1_RAT MPCIQAQYGTPATSPGPRDHLTGDPLALEFSKPTMDLASPETAPTAPATLPSFSTFMdgYTGEFDTFLYQLPGTAQPCS.
Q98TQ3_ORYLA MPCVQAQYGSSPqsYHTAGEYSCDFLTPEFVKFSMDLTNTEI..TATTSLPSFSTFMDNYNTGYDVKPPCLYQM......
O97726_PIG MPCVQAQypSPPGSSYAAQTYGSEYTtpDYTKLTMDLGSTEITATATTSLPSFSTFMEGYSSNYELKPSCLYQMQPSGPR
NR4A3_MOUSE MPCVQAQypSPPGSTYATQTYGSEYTtpDYTKLTMDLGSTGIMATATTSLPSFSTFMEGYPSSCELKPSCLYQMPPSGPR
NR4A3_RAT MPCVQAQypSPPGSTYATQTYGSEYTtpDYAKLTMDLGSTGIMATATTSLPSFSTFMEGYPSSCELKPSCLYQMPPSGPR
Q6NXU0_HUMAN ........................................................MDNYSTGYDVKPPCLYQM......
NR4A3_HUMAN MPCVQAQypSPPGSSYAAQTYSSEYTtpDYTKLTMDLGSTEITATATTSLPSISTFVEGYSSNYELKPSCVYQMQRPLI.
Q6INY4_XENLA MPCIQAQHGSLSQCAGPCDNYVPDILNSEFGKFTMDLVNSEIA..ASTSLPSFSTFMDGYTGEFDAF...LYQI......
NR4A2_XENLA MPCIQAQHGSLSQCAGPCDNYVPDILNSEFGKFTMDLVNSEIA..ASTSLPSFSTFMDGYTGEFDAF...LYQI......
Q7T0V3_XENLA MPCIQAQYGSLSQCAGPCDNYVPDILNSEFGKFTMDLVNSEIA..ASTSLPSFSTFMDGYTGEFDAF...LYQI......
Q6DH08_BRARE MPCVQAQYGTSPpsYNTTGEYNCDFLTPEFVKFSMDLTNAEIA..VTSSLPSFSTFVDTYSSNYDVKPPCLYQM......
Q6GMG3_BRARE MTCVQSQHGVQS...YESSLFSSEFLNPDFtrLAMDVTEQREQLSAP.SLPSITSLVGGYVGEFDTYSCQIATGAASTC.
HR38_DROME QQHQQQQQHLQLQLISPIGGPLSCGSSLPSFQETYSLKYNSSSGSSPQQASSSSTamdgGWSASPPAPSQLQQLHTLQS.
Q8INU7_DROME ..................................MDEDC..........FPPLS....GGWSASPPAPSQLQQLHTLQS.
Q9R1W4_MOUSE ........................................................MDNYSTGYDVKPPCLYQM......
Q9U4L1_AEDAE ..................................MDEDCFKIA.......ASPHHQSVGYG...................
O97727_PIG MPCVQAQypSPPGSSYAAQTYGSEYTtpDYTKLTMDLGSTEITATATTSLPSFSTFMEGYSSNYELKPSCLYQMQPSGPR
NHR6_CAEEL TDELQDQF.SNCSPASVDSSYSSCSSVEDEIEIYTRLVRNEE........PLRRDFFREMSKNSSCSSSFDYGEFGPSSS
Q61JK3_CAEBR .......................................................MMSKRTASKLEKPSTLAALEEQLR.
CONSENSUS ASSSASSTRASSSSPTSGQQSSFKVEDFQVYGCYPGPHSGPQDEELSPSGSDYYGSPCSPPSPSTPSFQPQQLSPWDDSF
NR4A1_HUMAN ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
Q6IBU8_HUMAN ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
Q6ZMM6_HUMAN ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
Q8N3V2_HUMAN ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPRSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
Q5RBB0_PONPY ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
NR4A1_CANFA ASSSASST..SSSSATSPASASFKFEDFQVYGCYPGPLSGPLDETLSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF
NR4A1_MOUSE ACSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSF
NR4A2_MOUSE ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPSTPSFQVQHSPMWDDPG
NR4A2_HUMAN ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPTTPGFQVQHSPMWDDPG !
NR4A2_RAT ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPSTPGFQVQHSPMWDDPG !
Q5R5Y4_PONPY ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPTTPGFQVQHSPMWDDPG
NR4A1_RAT ...SASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPPTPNFQPSQLSPWDGSF
Q98TQ3_ORYLA ..............PHSGEQSSIKVEDVQMHSYHQQSHLPPQSEEMIAHTGPMYFKPSSPHAPSTPNFQVQPNHMWEDPG
O97726_PIG PLIKMEEGRAHGYHHHHHDHHHHHHHQqqQQQPSIPPPSGPEDEVL.PSTSMYFK..QSPPspTTPVFPQQAGALWEDAL
NR4A3_MOUSE PLIKMEEGR..EHGYHHHHHHHHHHHHHQQQQPSIPPPSGPEDEVL.PSTSMYFK..QSPPspTTPGFPPQAGALWDDEL
NR4A3_RAT PLIKMEEGR.EHGYHHHHHHHHHHHHHHQQQQPSIPPPSGPEDEVL.PSTSMYFK..QSPPspTTPGFPPQAGALWDDEL
Q6NXU0_HUMAN ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPTTPGFQVQHSPMWDDPG
NR4A3_HUMAN ..KVEEGRAPSYHHHHHHHHHHHHHHQQQHQQPSIPPASSPEDEVL.PSTSMYFK..QSPPspTTPAFPPQAGALWDEAL
Q6INY4_XENLA ..............PSSNQQSSLKVEEFQVFGCYPGSFTNQLDETMSSSGSDYYGSPCSIPSPSTPGFQNPQLPTWECSY
NR4A2_XENLA ..............PSSNQQSSLKVEEFQVFGCYPGSFTNQLDETMSSSGSDYYGSPCSIPSPSTPGFQNPQLPTWECSY
Q7T0V3_XENLA ..............PSSNQQSSLKVEEFQVFGCYPGSFTNQVDETMSSSGSDYYGSPCSIPSPSTPGFQNPQLPTWECSY
Q6DH08_BRARE ..............AHSGDQLSIKVEEIPAHGYHQQQHHQpqAEESIPHTGAIYYKPSSPNISQSPSYPTAPHHTWEDTG
Q6GMG3_BRARE ............VGSTSGQLDSFKLDDLQVYGCYPGTflSYLDETLSSSgsNCFGSPASAPSPSTPGYQ..HMSAWDSTF
HR38_DROME ....QAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSayEYNGVSAADNFYGQQQQQQQQshNGER
Q8INU7_DROME ....QAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSayEYNGVSAADNFYGQQQQQQQQshNGER
Q9R1W4_MOUSE ..............PLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMpsGSVYYK.PSSPPTPSTPSFQVQHSPMWDDPG
Q9U4L1_AEDAE ................HHGYGHHAAAVHQPHYEFPQHTTAPPTQYSNPsgSFYPTpaVSQPRNTTqsFPQNYGAVTPQDS
O97727_PIG PLIKMEEGRAHGYHHHHHDHHHHHHHQqqQQQPSIPPPSGPEDEVL.PSTSMYFK..QSPPspTTPVFPQQAGALWEDAL
NHR6_CAEEL SRKGSKTTDADLDSLFHSLVETSDQVNTVPKPTKTEVESIPEEFEQKPSSSSHRLpiKSELDPTMQAFQMPH...NDLFL
Q61JK3_CAEBR .....ASGVIINTEFASLQDTSDQANVVPKPEVKVKVETIPE.EFEQPSSS....APSSSNQRALPSQSQLQPSVAPNPE
CONSENSUS GSHSPHQNYEALRHWTEQRKKAVSGLSLPPTFFKFSPPTTPSPSPAGSHLKMFPSPATHQLGEGHSYSVPTAFPPLAPTS
NR4A1_HUMAN GHFSPSQTYEGLRAWTEQLPKA.SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTS
Q6IBU8_HUMAN GHFSPSQTYEGLRAWTEQLPKA.SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTS
Q6ZMM6_HUMAN GHFSPSQTYEGLRAWTEQLPKA.SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTS
Q8N3V2_HUMAN GHSSPSQTYEGLRAWTEQLPKA.SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTS
Q5RBB0_PONPY GHFSPSQTYEGLRAWTEQLPKA.SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLASTS
NR4A1_CANFA GPFSPSQTYEGLRAWTEQLPKA.SGHPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATCQLGERESYSISTAFPGLAPTS
NR4A1_MOUSE GHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPATHQLGEGESYSMPAAFPGLAPTS
NR4A2_MOUSE SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
NR4A2_HUMAN SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
NR4A2_RAT SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSRPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
Q5R5Y4_PONPY SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
NR4A1_RAT GHFSPSQTYEGLRVWTEQLPKA.SGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPAPATHQLGEGESYSVPAAFPGLAPTS
Q98TQ3_ORYLA SLHSFHQNYvaTSHMMEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMRFDGPldNPGAHRGLDGQSFAVPSAIRKQAGLA
O97726_PIG PSAQGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGhlGYDPTAAAALglEGHPYGLPlaFSPLGLTT
NR4A3_MOUSE PSAPGCIAPGPLLDPQMKAVPPMAAAARFPIFFKPSPPHPPAPSPAGGhlGYDPTAAAALslEGHPYGLPLafPPLGLTA
NR4A3_RAT PSAPGCIAPGPLLDPQMKAVPPMAAAARFPIFFKPSPPHPPAPSPAGGhlGYDPTAAAALslEGHPYGLPLafPPLGLTA
Q6NXU0_HUMAN SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
NR4A3_HUMAN PSAPGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGhlGYDPTAAAALslEGHPYGlpLAFPPLGLTP
Q6INY4_XENLA GAYSPTQNYDNMRHWTEQQKNSISQ....QTFFSFGTPA.HSPNMAANPLKIAP..ATHRLdlAQNSSGGFPAVPLGQAP
NR4A2_XENLA GAYSPTQNYDNMRHWTEQQKNSISQ....QTFFSFGTPA.HSPNMAANPLKIAP..ATHRLdlAQNSSAGFPAVPLGQAP
Q7T0V3_XENLA GAYSPNQNYDNMRHWTEQQKNSISQ....QTFFSFGTPA.HSPNVAANPLKMAP..ATHRLdlAHNSSSGFPAIPLGQAH
Q6DH08_BRARE SLHSFHQNYLATShmDQQRKNAMSRL....FSFKQSPVDTPMPSCQMrhVSMGPDTAHRALDSFALPAPPRKQHGVGLSH
Q6GMG3_BRARE GPCSPDEGCWGSEKPLNQAA..........SFFTFGHVTADELSPLGQMQSQIPDQDPFSHTPQH..GSPLPFSPLSLEQ
HR38_DROME YSLPTFPTISELAAATAAVEAAAAATVgpPPVRRASLPVQRTVSPAGS.TAQSPKLAKITLNQRHSHAHAHA...LQLNS
Q8INU7_DROME YSLPTFPTISELAAATAAVEAAAAATVspPPVRRASLPVQRTVSPAGS.TAQSPKLAKITLNQRHSHAHAHA...LQLNS
Q9R1W4_MOUSE SLHNFHQNYVATTHMIEQRKTPVSRLSLFS..FKQSPPGTPVSSCQMrhVPMNPEPasHHVVDGQTFAVPNPIRKPapGL
Q9U4L1_AEDAE YSLPPFPTIAELHVSTTCYRRASLPLQreSTSSSESPKPPRVGIYKYSALPSASSSASSSPGYINNNN.PNTINNNEVAA
O97727_PIG PSAQGCIAPGPLLDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGhlGYDPTAAAALglEGHPYGLPlaFSPLGLTT
NHR6_CAEEL ATAAPHYNPFALSNDFMPNPLMPSFTS......PFYPQHFPVssRRGSQGTTSSSNNTGGTPSPHSSSLPTSPPQLQGFL
Q61JK3_CAEBR MNASIAHIKSELDPMqfQMPPNDLIFGAPHYPFsfYPQHFPVPAEArsQGNTSSSNNTGGTPSPHSNSLPTSPPQLHGFL
D010 D020 D030 D040 D050
|=========|=========|=========|=========|=
CONSENSUS PPLDASGLLDTPVPSPKSRSGASGSNEGRCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A1_HUMAN PHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q6IBU8_HUMAN PHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q6ZMM6_HUMAN PHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q8N3V2_HUMAN PHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q5RBB0_PONPY PHLEGSGILDAPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
NR4A1_CANFA PHLDGPGMLDAPVPSAKARSGAPSGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
NR4A1_MOUSE PNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRN
NR4A2_MOUSE QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A2_HUMAN QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A2_RAT QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
Q5R5Y4_PONPY QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A1_RAT PNCDTSGILDAPVTSTKARSGSSGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRN
Q98TQ3_ORYLA FPhhGHQLVDSQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
O97726_PIG SPTTSSLLGESplPSPPNRSTASG..EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A3_MOUSE SPTASSLLGESplPSPPNRSSSSG..EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A3_RAT SPTASSLLGESplPSPPNRSSSSG..EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
Q6NXU0_HUMAN QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NR4A3_HUMAN SPTASSLLGESplPSPPSRSSSSG..EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
Q6INY4_XENLA GVLDSSVLLDSPLSPSKTRSPSS..NEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
NR4A2_XENLA GVLDSSVLLDSPLSPSKTRSPSS..NEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q7T0V3_XENLA GVLDSSVLLDSPLSPSKTLSPSS..NEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRN
Q6DH08_BRARE SLNVGHPLLESPVASPQARG..SPSSEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
Q6GMG3_BRARE GSRDGSGLMDGHL.SPKVRS..PTGNEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKDCPVDKRRRN
HR38_DROME APNSAA...SSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRN
Q8INU7_DROME APNSAA...SSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRN
Q9R1W4_MOUSE QIGHASQLLDTQVPSPPSRG..SPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
Q9U4L1_AEDAE AAAAAAVAAAAVAGspAPRGPTPQSPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKACPVDKRRRN
O97727_PIG SPTTSSLLGESplPSPPNRSTASG..EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRN
NHR6_CAEEL RSFLNPDNLSTP.TSFGVPSETALDADKMCAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNKTCPIDKRYRS
Q61JK3_CAEBR RSFLNHDNLQTP.PTPFGIQDEVLDADKMCAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNKNCPIDKRYRS
D060 140 150
========|====== ===|=========|======
CONSENSUS RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPPPSPPVCLINALVRAHTDSTPRTAKLDYSKFQELVLYQFGK
NR4A1_HUMAN RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGK
Q6IBU8_HUMAN RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAFPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGK
Q6ZMM6_HUMAN RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGK
Q8N3V2_HUMAN RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGK
Q5RBB0_PONPY RCQFCRFQKCLAVGMVKEVVRTDSLRGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPRFGK
NR4A1_CANFA RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGK
NR4A1_MOUSE RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPRFGK
NR4A2_MOUSE RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
NR4A2_HUMAN RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
NR4A2_RAT RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
Q5R5Y4_PONPY RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
NR4A1_RAT RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLPRFGK
Q98TQ3_ORYLA RCQFCRFQKCLVVGMVREVVRTDNLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPSMSALDYSRFQANPDYQMTG
O97726_PIG RCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVCMMNALVRALTDSTPR..DLDYSRYCPADQAAAG.
NR4A3_MOUSE RCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPICMMNALVRALTDATPR..DLDYSRYCPTDQATAG.
NR4A3_RAT RCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPICMMNALVRALTDATPR..DLDYSRYCPTDQATAG.
Q6NXU0_HUMAN RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
NR4A3_HUMAN RCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPICMMNALVRALTDSTPR..DLDYSRYCPTDQAAAG.
Q6INY4_XENLA RCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKQIAESSPVSLINSLVRAHIDSIPSSSKLDYSKFQETVPLQLEK
NR4A2_XENLA RCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKQIAESSPVDLINSLVRAHIDSIPSSSKLDYSKFQETVPLQLEK
Q7T0V3_XENLA RCQFCRFQKCLAVGMVKEVVRTDNLKGRRGRLPSKPKQIAESSPVSLINSLVRAHIDSIPSSSKLDYSKFQETVPVQLEK
Q6DH08_BRARE RCQYCRFQKCLVVGMVKEVVRTASLKGRRGRLPSKPKSPQdfTPVNLLNALVRAHIDSNPSMARLDYSKFQTSPEYHSGG
Q6GMG3_BRARE RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKAVQdsSPVNIIASLVTAHIDSNPASANLDYSKYQESTSGLPEK
HR38_DROME RCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQ.....SM
Q8INU7_DROME RCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQ.....SM
Q9R1W4_MOUSE RCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSG
Q9U4L1_AEDAE RCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVSMITALVRAHVDTTPDLASLDYSQYREPGQNEPII
O97727_PIG RCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSppPSPPVCMMNALVRALTDSTPR..DLDYSRGHACGIWKFPG
NHR6_CAEEL RCQYCRYQKCLEVGMVKEIVRHGSLSGRRGRLSSKTKldQPSPPLPLLALMGKAIEDHTNMTV.............VRQF
Q61JK3_CAEBR RCQYCRFQKCLEVGMVKEIVRGGSLSGRRGRLSSKTKldQPSPPLPLLALMGKAIEDNTNMTV.............TRHF
330 340 350 450 550 560
==|=========|=========|=== ===|==========|=========|
CONSENSUS EDAEHVQQFYDLLTGSLDVIRKWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPGEGKLIFCNGLVLHRLQCVR
NR4A1_HUMAN EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
Q6IBU8_HUMAN EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
Q6ZMM6_HUMAN EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
Q8N3V2_HUMAN EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
Q5RBB0_PONPY EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
NR4A1_CANFA EDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPGDQDLLLESAFLELFILRLAYRSKPAEGKLIFCSGLVLHRLQCAR
NR4A1_MOUSE EDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHQLQCAR
NR4A2_MOUSE DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
NR4A2_HUMAN DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
NR4A2_RAT DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
Q5R5Y4_PONPY DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
NR4A1_RAT EDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR
Q98TQ3_ORYLA DNTQHIQQFYDLLTGSMEIIRGWAEKIPGFSDLPKQDQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
O97726_PIG TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR
NR4A3_MOUSE TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR
NR4A3_RAT TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR
Q6NXU0_HUMAN DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR
NR4A3_HUMAN TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR
Q6INY4_XENLA ESSVDVQQFYDLLSGSLEVIRKWAEKIQGFVDLPKEDQDLLLESAFLELFILRLAYRSRPEEGKLIFCNGVVLHRTQCVR
NR4A2_XENLA ESSVDVQQFYDLLSGSLEVIRKWAEKIQGFVDLPKEDQDLLLESAFLELFILRLAYRSRPEEGKLIFCNGVVLHRTQCVR
Q7T0V3_XENLA ESSVDVQQFYDLLSGSLEVIRKWAEKIQGFVDLPKEDQDLLLESAFLELFILRLAYRSRPEEEKLIFCNGVVLHRTQCVR
Q6DH08_BRARE DESLHIQQFYDLLTASMSIIRGWAEKIPGFTELPKCDQELLFESAFLELFVLRLAYRSNLPEDKLIFCNGMVLHKLQCVR
Q6GMG3_BRARE EDANDIQQFYDLLTGSMDVIRKWAGSIPGFSAFCKEDQELLLESAFVELFILRLAYRSNPETDKLIFCNGVVLHRTQCVR
HR38_DROME SEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLR
Q8INU7_DROME SEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLR
Q9R1W4_MOUSE DDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRI......................
Q9U4L1_AEDAE SEAEKVQQFYNLLTTSVDVIKQFADKLPGFSDLSSDDQELLFQSASLELFVLRLSYRARIDDTKMTFCNGVVLHKHQCQR
O97727_PIG ................................................................................
NHR6_CAEEL MQPFDETIALRILHGELHATKKLLMAMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTDTIMFESG.ELFSLNAfq
Q61JK3_CAEBR LAPFGEDSAVSILHCEYIATRKLLMAMPQICEIPEPDFRILLARSFFPIMAIRCANRCANNTESIMFESG.ELFMLNAfq
740 750 850 940 950 1040
====|========|= ==|========= ====|=========|======== ==|=====
CONSENSUS GFGEWIDSILEFSSNLQSLNIDISAFACLSALAMITDRHGLKEPKRVEELQNKIVSCLKDHVTFNAGEPNRPNYLSKLLG
NR4A1_HUMAN GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG
Q6IBU8_HUMAN GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG
Q6ZMM6_HUMAN GFGDRIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG
Q8N3V2_HUMAN GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG
Q5RBB0_PONPY GFGDWIDSILAFSRSLHSLVVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG
NR4A1_CANFA GFGDWIDSILAFSRSLHGLVVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVSAVAGEPQPASCLSRLLG
NR4A1_MOUSE GFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLG
NR4A2_MOUSE GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG !
NR4A2_HUMAN GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG
NR4A2_RAT GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG
Q5R5Y4_PONPY GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHWLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG
NR4A1_RAT GFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMAAVAGDPQPASCLSRLLG
Q98TQ3_ORYLA GFGEWVDAIVEFSSNLQSLDIDISAFSCIAALAMVTERHGLKEPKRVEDLQNKIVNCLKDQVTFNSGGLNRPNYLSKLLG
O97726_PIG GFGEWLDSIKDFSLRLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKEHQSKGQ...ALEPTEPKVLR
NR4A3_MOUSE GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCTKITSSLKDHQRKGQ...ALEPSEPKVLR
NR4A3_RAT GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKDHQRKGQ...ALEPSEPKVLR
Q6NXU0_HUMAN GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG
NR4A3_HUMAN GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKDHQSKGQ...ALEPTESKVLG
Q6INY4_XENLA GFGEWIDSIIEFSHSLQRMNIDVPSFSCLSALVIVTDRHGLKEPKKVEELQSQIINCLKEHIPSSMNEQNRPNCLSKLLG
NR4A2_XENLA GFGEWIDSIIEFSHSLQRMNIDVPSFSCLSALVIVTDRHGLKEPKKVEELQSQIINCLKEHIPSSMNEQNRPNCLSKLLG
Q7T0V3_XENLA GFGEWIDSIIEFSHNLQRTNIDVPSFSCLSALVIITDRHGLKEPKKVEELQSRIINCLKEHAPSSMNEQNRPNCLSKLLG
Q6DH08_BRARE GFGEWIDSIVEFSSNLQSMSLDVSAFSCIAALTIVTERHGLKEPKKAEELQNKLINCLKDQVSCSG.......ELSKLLE
Q6GMG3_BRARE SFGDWIDSIMEFSQSLHRLNLDISAFSCLATLVIITDRHGLKEPKRIEDFQNRLITCLRDHVSTSALEVGRPNSLSRLLS
HR38_DROME SFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLG
Q8INU7_DROME SFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLG
Q9R1W4_MOUSE ................................................................................
Q9U4L1_AEDAE SFGDWLNAILEFSKSLHSMEIDISAFACLCALTLVTERYGLREPKKVELLQMKIISSLRDHVTYNSEAQRKPHYFNRLLG
O97727_PIG ................................................................................
NHR6_CAEEL IIRFMVDKARTFSSLVDWEPQAFAAFIALQFLAGNTEHngLTNKPLVDQVQSTIINALKDHCSGSQNKLAKIVRLTQEFD
Q61JK3_CAEBR ILRFMINKAQNFSSLVEWEPQAFASFIALQFLSGNTEQngLSNKVLVDTVQSTIINALKDHCSGSQ......NKLAKIVR
1050 1060 1250
====|=========|= =====|==
CONSENSUS KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
NR4A1_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF.......................................
Q6IBU8_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF.......................................
Q6ZMM6_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF.......................................
Q8N3V2_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF.......................................
Q5RBB0_PONPY KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF.......................................
NR4A1_CANFA KLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF.......................................
NR4A1_MOUSE KLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF.......................................
NR4A2_MOUSE KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF....................................... !
NR4A2_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF....................................... !
NR4A2_RAT KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF....................................... !
Q5R5Y4_PONPY KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF.......................................
NR4A1_RAT KLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF.......................................
Q98TQ3_ORYLA KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF.......................................
O97726_PIG ALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTLPF.......................................
NR4A3_MOUSE ALVELRKICTQGLQRIFYLKLEDLVPPPSVIDKLFLDTLPF.......................................
NR4A3_RAT ALVELRKICTQGLQRIFYLKLEDLVSPPSVIDKLFLDTLPF.......................................
Q6NXU0_HUMAN KLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF.......................................
NR4A3_HUMAN ALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTLPF.......................................
Q6INY4_XENLA KLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF.......................................
NR4A2_XENLA KLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF.......................................
Q7T0V3_XENLA KLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF.......................................
Q6DH08_BRARE KLPEVRALCTQGLQRIFYLKLEDLVPTPAIIDKLFHDTLPF.......................................
Q6GMG3_BRARE KLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF.......................................
HR38_DROME KLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF.......................................
Q8INU7_DROME KLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF.......................................
Q9R1W4_MOUSE ................................................................................
Q9U4L1_AEDAE KLPELRSLSVQGLQRIFYLKLEDLVPAPPLIENMFLASLPF.......................................
O97727_PIG ................................................................................
NHR6_CAEEL VFHALGLQALDILYPSHQLPEEFMFLINLTRAPLRSTDAPP.......................................
Q61JK3_CAEBR LTDEFDVFHTMGIQVLDSMYpeFQHLISLTRAPLRtdTQPA.......................................