2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS MDSSNVPSSLLSPSLPNSSQSPLPMDSGPVCIPSPYTELGHEFSTMPFYSPAVMGYSIPPSVTNSDCGPVRQSLSPNLFW
Q8BG65_MOUSE MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLW
ESR2_HUMAN MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLW !
ESR2_MOUSE MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLW
ESR2_RAT MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLW
ESR2_CALJA MDIKNSPSSLNSPSSYNFGQSILPLEHGPIYIPSSYVESHHEYPAMTFYSPAVMNYSIPSSVTNLEEGPGRQITSPNMLW
ESR2_SHEEP MDVKNSPSSLNSPVSYNCGQSILPLEPGPIYLPSSYVESRHEYSAVTFYSPAVMNYSIPN...NSEDGPGRQTTSPNVLW
ESR2_BOVIN MDVKNSPSSLNSPVSYNCGQSILPLEPGPIYLPSSYVESRHEYSAVTFYSPAVMNYSIPN...NSEDGPGRQTTSPNVLW
ESR2_PIG MDIKNSPSNLNSPVSYNCSQSVLPLEPGPIYIPSSYVESCHEYSAMTFYSPAVVNYSISS...NSEVGPGRQATSPNVLW
Q90WS8_BRARE VDSGRVGGHILSP.IFNSSSPSLPVENHPICIPSPYTDLGHDFSTLPFYSPALLGYSTSP...LSDCSSVRQSLSPTLFW
Q7ZU32_BRARE VDSGRVGGHILSP.IFNSSSPSLPVENHPICIPSPYTDLGHDFSTLPFYSPALLGYSTSP...LSDCSSVRQSLSPTLFW
Q8AV62_BRARE VDSGRVGGHILSP.IFNSSSPSLPVENHPICIPSPYTDLGHDFSTLPFYSPALLGYSTSP...LSDCSSVRQSLSPTLFW
Q98SM7_BRARE VDSGRVGGHILSP.IFNSSSPSLPVENHPICIPSPYTDLGT.TSAlpFTVPLCWGTSTSP...LSDCSSVRQSLSPTLFW
Q8JJB9_CYPCA VDSSRVGGHVLSP.AFNSSSPSLPVESHPICIPSPYTDLSHDFTTLPFYSPALLGYGAAP...LSDCPSVRQSLSPSLFW
ESR2_ONCMY VDSSRVGGHILSP.IFNSSSPSLPVESHPVCIQSPYTDLGHDFTTLPFYSPALLGYGTSP...LSECSSVRQSLSPTLFW
ESRB1_CARAU VDSSRMGGHVLSP.TFNSSSPSLPVESHPICIPSPYTDLGHDFTTLPFYSPSLLGYGTSP...LSDCPSVRQSLSPTLFW
Q91Z86_MOUSE .............................................MTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLW
ESR2_STUVU TEIKNSPAGVISPAPYSCNQSTLTAEHSPVYIPSSYMESRHEYSTMAFCSPAMVNYNIASNFGDPEAVAARQTSSPGALW
Q95MF0_MACAR MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVESHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTASPNVLW
Q6XSH2_MICSA VDSSKASQRPSSP.lPAVYSPPLGMDSHTVCIPSPYTDSSHEYNhlTFYSPSVLSYARPPI.TDSP.SSLCPPLSPSAFW
ESR2_MICUN VGSSKVSERPRSP.lPAVYSPPLGMDSHTVCIPSPYTDSSHEYNhlTFYSPSVLSYSRPPI.TNSP.SSLCPSLSPSAFW
ESR2_ANGJA VDSSKvgSSGLLPTMYNGALPALSMESHAVCIPSPYTDSSHDYAALTFYSPPILSHGGPA...VPESPAARQSLSPSLFW
Q8QHK9_PAROL VDSSRVRSCVLSP.ILSTSSPGLSLdsQPICIPSPYTELGHDFATIPFYGPTIFSYAAPS...IPDCPSVHQSLSPSLFW
Q6H9M5_SPAAU VDSSKPSERPSSP.lPAAYSPPLGMDSHTVCIPSPYADSSHEYNhlNFYSQSVLSYARQP.VTDSP.SYLCPSISPSAFW
Q6H9M4_SPAAU VDSSKPSERPSSP.lPAAYSPPLGMDSHTVCIPSPYADSSHEYNhlNFYSQSVLSYARQP.VTDSP.SYLCPSISPSAFW
Q6XSH1_MICSA VDSSRVGSRVVSP.ILN...SPLE.TSQPICITSPYTDHSHDFTTIPFYNPTIFSYA.SP..GISDRPSVHQSLSPSLFW
Q5PR29_BRARE LDSSKADRG.ASP.lPRLYASPLGMDNQTVCIPSPYVEACQDYsaLTLYSPvvLGFHRPP...VSES...LVPLSPTILW
Q98SM8_BRARE LDSSKADRG.ASP.lPRLYASPLGMDNQTVCIPSPYVEACQDYsaLTLYSPvvLGFHRPP...VSES...LVPLSPTILW
Q90WS9_BRARE LDSSKADRG.ASP.lPRLYASPLGMDNQTVCIPSPYVEACQDYsaLTLYSPvvLGFHRPP...VSES...LVPLSPTILW
Q762D6_CONMY VDSSKvgSAGLLPSMYNGALPTLSMENHAVCIPSPYTDSGHDYTTLTFYRPPILGHAGPA...VPEGPDVHPSLSPSLFW
ESR2_SPAAU VDSSRV...ILSP...VLSSP...MenQPICIPSPYTDRGHDFPTIPFYSATNFSYANPP..AISDRPSVHQTLSPSLFW
Q7T3U4_9TELE MDSGNANRG.DSP.lPHLYTSPLGMDSRTICIPSPYVEACQDYsaLTLYSPvvLGYTHPP...VSES...LVPLSPTIFW
Q95ME9_CALJA MDIKNSPSSLNSPSSYNFGQSILPLEHGPIYIPSSYVESHHEYPAMTFYSPAVMNYSIPSSVTNLEEGPGRQITSPNMLW
Q7T2K7_9LABR VDSSKASERPSSP.lPAVYSPRQGMDSHTVYIPSPYTDNNQEYNhvSFYSPSVLSYARPSA.TDSP.SSLCGPLSPSAFW
ESR2_ORENI VDSSRAGSRILSP.ILGSSSPGLSHesQPICIRSPYTDLGHDFTTIPFYSPTIFSYGGPS...ISECSSVHQSLSASLFW
Q804Q7_ACASC VDSSRV...ILSP...VLSSP...MenQPICIPSPYTDRGHDFPAIPFYSPTNFSYANPPS..ISDRPSVHQTLSSSLFW
ESRB2_CARAU MSSspAPAS.ASP.lPLLYTSQLGMDSQTICIPSPYVEACQDYsaLTLYSPvvLGYTHPP...VSE..SLVPLNSA.IFW
Q7T3U5_9TELE LDSGKADRG.DSPtlPHLYTSPLGMDSQTICIPSPYLEACQDYsaLTLYSPvvIGYPHPP...VSES...LVPLSPTIFW
Q6R7S4_SALSA VDPSRvgGRILSP.IFSAPSPALPMEAHPICIPSPYTDIGHDFNPLSFYSPTLLSYAGPA...LPDCPSAHQSLSPSIFW
Q8UW75_ORYLA VDSSRAGSCVLSP.NLSSSSPGLSHesQPICIPAPYADLSHDFTSLPFYNPTIFSYASPS...MSECPSVHQSLSASLFW
ESR3_MICUN VDSSRVGGQVLSP...TLSSS.LE.TSQPICITSPYTDLGHDFPTIPFYSPTIFSYAGPS...ISDCTSVHQSLNPSLFW
ESR2_COTJA .............................................MAFCSPAMMNYNIASNFGDSESASVRQTSSPSLLW
ESR2_CHICK .............................................MAFCSPAMLNYNIASNFGDSESASVRQTSSPSVLW
ESR2_ICTPU MSSSLSPTLQtlPLFPSHYPTALGVDRGTVCIPSPYADNGHAE..MSFCGPS......AP.....ENPAIAPPLSPSLFW
Q90ZE6_SQUAC vhIKNSPTGltQP.QYSSTLPGLS.EHGPVCIPSSYVENRHEFPTLAFYSPSILGYSMPSDASGPDGTIVRQSLSPSMYW
D010
|==
CONSENSUS PSHGHLSPLALHCQSRLLYAEPQHSPWCEAKPLDHVLPVSKKTLKRSVEGSECTSPVTSPGSKRDMHFCAVCSDYASGYH
Q8BG65_MOUSE PTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYH
ESR2_HUMAN PTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYH
ESR2_MOUSE PTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYH
ESR2_RAT PTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYH
ESR2_CALJA STPGHLSPLAVHHQLSHLYAEPQKSPWCEARSLEHTLPVSRETLKRKVSGNHCASPVTGPSSKRDAHFCAVCSDYASGYH
ESR2_SHEEP PTPGHLSPLAIHCQSSLLYAEPQKSPWCETRSLEHTFPVNRETLKRKASGSSCASPVSSPSSKRDAHFCAVCSDYASGYH
ESR2_BOVIN PTPGHLSPLAIHCQPSVLYAEPQKSPWRETRSLEHTLPVNRETLKRKASGSSCASPATSPSSKRDAHFCAVCSDYASGYH
ESR2_PIG PTPGHLSPLAIHCQPSLLYAEPQKSPWCDTRSLEHTLPVNRETLKRKASGSSCASPVTSPSSKRDAHFCAVCSDYASGYH
Q90WS8_BRARE PPHSHVSSLTLQQQSRLQQNHATSGTWTEHTPHDHVEEENSKPLVKRVADTEETS..VSLRGKADMHYCAVCSDYASGYH
Q7ZU32_BRARE PPHSHVSSLTLQQQSRLQQNHATSGTWTEHTPHDHVEEENSKPLVKRVADTEETS..VSLRGKADMHYCAVCSDYASGYH
Q8AV62_BRARE PPHSHVSSLTLQQQSRLQQNHATSGTWTEHTPHDHVEEENSKPLVKPVAETEETS..VSLRGKADMHYCAVCSDYASGYH
Q98SM7_BRARE PPHSHVSSLTLQQQSRLQQNHATSGTWTEHTPHDHVEEENSKPLVKRVADTEETS..VSLRGKADMHYCAVCSDYASGYH
Q8JJB9_CYPCA PPHNHVSSVVLHqqTRLQQNHPTGGSWAELTPHDHSEEENCKPLAKRVADAEETS..ASLRGKADMHYCAVCSDYASGYH
ESR2_ONCMY PPHSQVSSLALHQQ.rLQQNHPTGGTWTELTPHDHSEEEYRKPLVKRVADAEETS..TSLRGKADMHYCAVCSDYASGYH
ESRB1_CARAU PPHSHVSSLALHqqTRLQPNHPTGGTWAELTPHDHGEEENCKPLSKRVAVAEETS..TSLRGKADMHYCAVCSDYASGYH
Q91Z86_MOUSE PTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYH
ESR2_STUVU SAPGHLSPLSLHCQSSLLYAEQPKSLWCEARPMEPVLPGSRETLKRKTNGNDCTSPinNPGSKKDAHFCAVCSDYASGYH
Q95MF0_MACAR PTPGHLSPLAVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCTSPVTSPSSKRDAHFCAVCSDFASGYH
Q6XSH2_MICSA PSHSHppSLTLRCPQPLVYNEP.hAHWPEPKAHSINPSsnKPLGKRLEEGVEgsSLCSSAVGKADMHFCAVCHDYASGYH
ESR2_MICUN PSHNHppSLTLHCPESIVYNEP.hAPWLESKAHSINASsnKSLVKRSEEGVenSSLCSSAVGKADMHFCAVCHDYASGYH
ESR2_ANGJA PahGHVSPLALHFQQPLVYREPAHSPWAEPKPLEHGQatSKLAGKRMAESEEGTSSVGGcaGKGDMHFCAVCHDYASGYH
Q8QHK9_PAROL PSHGH.pPMTLHrqGRSQQGQPIQSPWGELTPRDGVLANSKGVRRRSQESEDG...VVSSGGKSDLHYCAVCHDYASGYH
Q6H9M5_SPAAU PSHNHppSLTLQCPQPHVYNEP.hAPWLEPKAHAVTTSsnKLPGKRSDERGEGasSCSSAVEKADMHFCAVCHDYASGYH
Q6H9M4_SPAAU PSHNHppSLTLQCPQPHVYNEP.hAPWLEPKAHAVTTSsnKLPGKRSDERGEGasSCSSAVEKADMHFCAVCHDYASGYH
Q6XSH1_MICSA PSHGHvsPIPLHhqPRPQYRQPIQNPWAELSPLESTLTTSKSVRRRSQESQE..SVVSS.GGKADLHYCAVCQDYASGYH
Q5PR29_BRARE PPH......SLHYPPPLAYSET.hSAWEEAKTHTLSQSSSvkLLGQQLEGDNGLNPSASIVGKGDTHFCAVCHDYASGYH
Q98SM8_BRARE PPH......SLHCPPPLAYSET.hSAWEEAKTHTLSQSSSvkLLGQQLEGDNGLNPSASIVGKGDTHFCAVCHDYASGYH
Q90WS9_BRARE PPH......SLHCPPPLAYSET.hSAWEEAKTHTLSQSSSvkLLGQQLEGDNGLNPSASIVGKGDTHFCAVCHDYASGYH
Q762D6_CONMY PshGHVPQLALHFQQPLLYREPPHSPWGDPKPLEQGHAQTSKLTKRVAESEEGASSGGGcaGKGDMHFCAVCHDYASGYH
ESR2_SPAAU PSHGHvtTLPLHhqARPQHGQAVQSPWVELSPLDNVLTSSKSARRRSQENEEG...EVSSGGKADLHFCAVCHDYASGYH
Q7T3U4_9TELE PPHTTHPALSLHCPPPLAYSET.hTTWEDAKTHMINQGSSVLtfGQQLDGDGGLNPSPGVLGKGDAHFCAVCHDYASGYH
Q95ME9_CALJA STPGHLSPLAVHHQLSHLYAEPQKSPWCEARSLEHTLPVSRETLKRKVSGNHCASPVTGPSSKRDAHFCAVCSDYASGYH
Q7T2K7_9LABR PPHSQppSLTLRCPQPLGYNESghAPWLESKPHNISSSsnKPLGKRSEEGVNGvsLCSSVVGKADMHFCAVCHDYASGYH
ESR2_ORENI PSHGRvtPITLHcqGRSQQGQSAQTPW......DSVITTSKSVRRRSQES.EE.SMVSS.GGKADLHYCAVCHDYASGYH
Q804Q7_ACASC PSHGHvtTLPLHhqARPQHGQPVQSPWVELSPLDNVLTSSKSARRRSQESEEG...EVSSGGKADLHFCAVCHDYASGYH
ESRB2_CARAU PPHPTHSTPSLHCPSPLAYRET.hTTWEDAKTH.INQSSSVLtlGQQLDGDDGLNPSPGILGKGDTHFCAVCHDYASGYH
Q7T3U5_9TELE PSHTTHTALSLHCPPQVAYSET.hTAWKDARTHTLNQSSSVLtlAQQVEGDDGLNPSPGIVGNGDTHFCAVCHDYASGYH
Q6R7S4_SALSA PPQAHvpPLSLHhqSRPQQGQPTRVSWAE..PH..ALSESSKPLRKCSQESEE..TVISLEGKAELHFCAVCHDYASGYH
Q8UW75_ORYLA QSHGHvpTIPLHrqARAQHGQPIQSPW......DGVLTTSKGVRRRSQES.EE..AVVSSGGKSELHYCAVCHDYASGYH
ESR3_MICUN PSRGH.sPIPLHHS...QHGQPIQSPWVEISPLDNVlpVRHkaRRRSQES.EEAV.VTS.GGKTDLHYCAVCHDYASGYH
ESR2_COTJA SAPGHLSPLTLHCQLSLLYAEQPKSPWCEARPLEPVLPVSRETLKRKTNGSDCTSPIAS.gSKRDAHFCAVCSDYASGYH
ESR2_CHICK SAPGHLSPLTLHCQSSLLYAEQPKSPWCEVRPLDPVLPVTRETLKRKTNGSDCTSPIAS.gSKRDAHFCAVCSDYASGYH
ESR2_ICTPU SSHNPhpALPLHCPPALPYSEP.hTAWVDTKPHTSglSRPKLFGKRPEDGddEasSSSGAVVKRDMHFCVVCHDYASGYH
Q90ZE6_SQUAC SSTGHVSPITLHCQQPIMYAEPPKSPWDDLRSGDQHLL.NRENLKKKPAP.PG.SSVNGVCSRRDAHFCAVCNDFASGYH
D020 D030 D040 D050 D060
=======|=========|=========|=========|=========|======
CONSENSUS YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGSRRERCGYRGARHQGNPSERGH
Q8BG65_MOUSE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVH
ESR2_HUMAN YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH !
ESR2_MOUSE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVH
ESR2_RAT YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVH
ESR2_CALJA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQGNAEEQLH
ESR2_SHEEP YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRNSDEQLH
ESR2_BOVIN YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRNSDEQLH
ESR2_PIG YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRKQRNSEGHLH
Q90WS8_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSyrLVRFSGRMRMTGP
Q7ZU32_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSyrLVRFSGRMRMTGP
Q8AV62_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSyrLVRFSGRMRMTGP
Q98SM7_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSyrLVRFSGRMRMTGP
Q8JJB9_CYPCA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRGSyrLARFSGRMRTCGP
ESR2_ONCMY YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRGSyrLARFSGRMRTSGP
ESRB1_CARAU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGLRRDRSSyrGarFSGRMRTSGP
Q91Z86_MOUSE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVH
ESR2_STUVU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGSRRERCGYRILRSHRGAEERVH
Q95MF0_MACAR YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQVH
Q6XSH2_MICSA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRGGLQPRD
ESR2_MICUN YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRGGLQPRD
ESR2_ANGJA YGVWSCEGCKAFFKRSIQGHNGYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCTYRGARHRRMPHIREl
Q8QHK9_PAROL YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMTKCGMRKDHGSYR.tRRLTRLSSQGR
Q6H9M5_SPAAU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRGGLQARD
Q6H9M4_SPAAU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRGGLQARD
Q6XSH1_MICSA YGVWSCEGCKAFFKRSIQRHNDYICPATNQCTIDKNRRKSCQACRLRKCNEVGMTKFGIRKERGNCR.mRRVTRLSTQGR
Q5PR29_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRNPQIRDS
Q98SM8_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVDMMKCGVRRERCSYRGARHRRNPQIRDS
Q90WS9_BRARE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRNPQIRDS
Q762D6_CONMY YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCTYRGARHRRLPQIRDL
ESR2_SPAAU YGVWSCEGCKAFFKRSIQRHNDYICPATNQCTIDKNRRKSCQACRLHKCYNVGMTKCGMRKERGNFR.mRRVTRLSSQGR
Q7T3U4_9TELE YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHHRNPQIRDS
Q95ME9_CALJA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQGNAEEQLH
Q7T2K7_9LABR YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGTRHRRGGLQPRD
ESR2_ORENI YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMTKCGIRKERGNYR.aRRLTRLSSQGK
Q804Q7_ACASC YGVWSCEGCKAFFKRSIQRHNDYICPATNQCTIDKNRRKSCQACRLHKCYNVGMTKCGMRKERGNFR.mRRVTRLSSQGR
ESRB2_CARAU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGGRHRRNPPIRDS
Q7T3U5_9TELE YGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKSRRKSCQACRLRKCYEMGMMKCGVRRERCSYRGARHRRNPQIRDS
Q6R7S4_SALSA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMTKCGMRRDRSSYRGhrRVGRFFTRGT
Q8UW75_ORYLA YGVWSCEGCKAFFKRSIQGHTDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMTKCGVRKERSSYRSarRAGRLTSQGR
ESR3_MICUN YGVWSCEGCKAFFKRSIQRDNEYICPATNECTIDKNRRKSCQACRLRKCYEVGMTKCGMRKERGNYR.mRRMTRLTSQGR
ESR2_COTJA YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGSRRERCGYRILRRHRN.SE..D
ESR2_CHICK YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGSRRERCGYRILRRHRN.SE..D
ESR2_ICTPU YGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEMGMMKCGARRERCGYRASRR.TAP.MRDG
Q90ZE6_SQUAC YGVWSCEGCKAFFKRSIQGHNAYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKSETRRDRCSYRLTRQNRLSSAQAQ
140 150 330 340 350
===|=========|====== ==|=========|=========|===
CONSENSUS CSGKAKRRGGPVGRVKEVLLSALSPEQLVLTLLEAEPPEVLLSRMSKPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
Q8BG65_MOUSE CLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFV
ESR2_HUMAN CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFV !
ESR2_MOUSE CLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFV
ESR2_RAT CLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFV
ESR2_CALJA CAGKAKRSGGHVPRVRELLLSALSPEQLVLTLLEAEPPHVLISRPSVPFTEASMMMSLTKLADEELVHMISWAKKIPGFV
ESR2_SHEEP CLSKTKRNGAPMTRVKELLLSALSPEQLVLTLLEAEPPHVLMSRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
ESR2_BOVIN CLSKTKRNGGPMTRVKELLLSALSPEQLVLTLLEAEPPHVLISRPSTPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
ESR2_PIG CLSRAKKNGDHTTRVKELLLSTLSPEQLVLTLLEAEPPHVLVSRPSTPFTEASMMMSLTKLADKELVHMISWAKKIPGFM
Q90WS8_BRARE RSQEIKSIPRP.LSGNEVVRISLSPEELISRIMEAEPPEIYLmdMKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q7ZU32_BRARE RSQEIKSIPRP.LSGNEVVRISLSPEELISRIMEAEPPEIYLmdMKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q8AV62_BRARE RSQEIKSIPRP.LSGNEGARISLSPEELISRIMEAEPPEIYLmdMKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q98SM7_BRARE RSQEIKSIPRP.LSGNEVVRISLSPEELISRIMEAEPPEIYLmdMKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q8JJB9_CYPCA RSQEIKSVPRP.LGGNKVVSIALSPEELIARIMDAEPPEIYLmdVKKPFTEANIMMSLTNLADKELVHMISWAKKIPGFV
ESR2_ONCMY RSQEMKSVPCP.LSGNEVVNMALTPEELIARIMDAEPPEIYLmdMKKPFTEANVMMSLTNLADKELVHMISWAKKVPGFV
ESRB1_CARAU RSQEIKTVQRP.LSGNKVVTMALSPEELIARIMDAEPPEIYLmdVKKPFTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q91Z86_MOUSE CLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFV
ESR2_STUVU CLGRARRYSEAATRVKEILLSTVSPEQFVLTLLEAEPPHVLVSRPSKPFTEASMMMSLTKLADKELVHMIGWAKKIPGFI
Q95MF0_MACAR CASKAKRSGSHTPLVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
Q6XSH2_MICSA PTGRGLVRMGL.GSrnHVHPSAMSPEEFISRIMEAEPPEIYLmdMKKPFTEASMMMSLTNLADKELVLMISWAKKIPGFV
ESR2_MICUN PTGRGLVRVGL.GSrkHVHLSAMSPEEFISRIMDAEPPEIYLmdLKKPFTEASMMMSLTNLADKELVFMISWAKKIPGFV
ESR2_ANGJA tGGGaqRRGEgvPQTQEAQSSALTPEQLINRIIEAEPPEIYLmeLKKPFTEDSMMMSLTNLADKELVLMISWAKKIPGFV
Q8QHK9_PAROL ASGPKALTGPVVALMNELQPPALTPEQLIERIMEAEPPVIYLmdMSGPLTEANVMMSLTHLADKELVHMITWAKKIPGFV
Q6H9M5_SPAAU PTGRGLVRVGL.GSrkRVHHSAMSPEEFISRIMEAEPPEIYLmdMNKPFTESSMMMSLTNLADKELVLMISWAKKIPGFV
Q6H9M4_SPAAU PTGRGLVRVGL.GSrkRVHHSAMSPEEFISRIMEAEPPEIYLmdMNKPFTESSMMMSLTNLADKELVLMISWAKKIPGFV
Q6XSH1_MICSA TNRPAVLTGPAAGSLIVPHSPALTPEQLIERIMDAEPPEIDLmdMRRPLTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q5PR29_BRARE SGGVVGLRG.pSGGRAEGRGLNYSPEQLVSCILEAEPPQIYLREpkKPYTEASMMMSLTSLADKELVLMISWAKKIPGFV
Q98SM8_BRARE SGGVVGLRG.pSGGRAEGRGLNYSPEQLVSCILEAEPPQIYLREpkKPYTEASMMMSLTSLADKELVLMISWAKKIPGFV
Q90WS9_BRARE SGGVVGLRG.pSGGRAEGRALNYSPEQLVSCILEAEPPQIYLREpkKPYTEASMMMSLTSLADKELVLMISWAKKIPGFV
Q762D6_CONMY AgaRAHRRGE..GPATQVHTSALTPEQLIHRIVEAEPPEIYLmeLKKPFTEDSMMRSLTNLADKELVLMISWAKKIPGFV
ESR2_SPAAU TSGPSVLNGPAVGPLNTPQPPALTSKQLIERIMEAEPPEIYLmdMRRPLTEANIMMSLTNLADKELVHMITWAKKIPGFL
Q7T3U4_9TELE SGGALGVRR.HsgDRAEGCGRSLSPEQLVNCILEAEPPQIYLREpkKPYTEASMMMSLTNLADKELVLMISWAKKIPGFV
Q95ME9_CALJA CAGKAKRSGGHVPRVRELLLSALSPEQLVLTLLEAEPPHVLISRPSVPFTEASMMMSLTKLADEELVHMISWAKKIPGFV
Q7T2K7_9LABR PTGRGLVRVGL.GSRAQRHlaAMSPEEFIMRIMEAEPPEIYLmeQKKPFTEASMMMSLTNLADKELVLMISWAKKIPGFV
ESR2_ORENI TAEPKGITGPAEGSLNKPEKPALTPEQLIERILEAEPPEIYLvdAKRPLTEASVMMLLTNLADKELVHMISWAKKIPGFV
Q804Q7_ACASC TNGPAV...GP...LIAPQPPALTSKQLIERIIEAEPPEIYLmdVRRPLTEANIMMSLTNLADKELVHMITWAKKIPGFL
ESRB2_CARAU SGGAIGVRGhpLGDRAEGCGQNLSPEQLVNCILEAEPPQIYLREpkKPYTEASMMMSLTNLADKELVLMISWAKKIPGFV
Q7T3U5_9TELE SGGALGVRG.pSGGRAEGCGLSFSPEQLVNCILEAEPPQICLREpkKPYTEASMMMSLTSLADKELVLMISWAKKIPGFV
Q6R7S4_SALSA ASGPKRVLAEGGEPIKELRPTVLTPEQLIGRIMEAEPPEIYLqdMRRPLTEANVMMSLTNLADKELVHMISWAKKIPGFV
Q8UW75_ORYLA MNGPKVSSGPKESSGNEQSSLHLTPEQLIARMMEAEPPDIYLmdTKKPLTEAVVMMSLTNLADKELVHMITWAKKIPGFV
ESR3_MICUN TDSSSVLTGSAVVSLNAPQPSALTSEQLIERLMEAEPPEIYLmdMKKPLTEAKVMMSLTNLADKELVHMITWAKKIPGFV
ESR2_COTJA CMGKTKKYNEAATRVKEILLSTVSPEQFVLTLLEAEPPNVLVSRPSKPFTEASMMMSLTKLADKELVHMIGWAKKIPGFI
ESR2_CHICK CMGKTKKYNEAATRVKEILLSTVSPEQFVLTLLEAEPPNVLVSRPSKPFTEASMMMSLTKLADKELVHMIGWAKKIPGFI
ESR2_ICTPU SARPVGVRGqpHtsRaeSGFSGLSPEQLVYCILEAEPPQIYLkqMKKPYTESTVMMSLTQLADKELVLMISWAKKIPGFV
Q90ZE6_SQUAC HWSRGKRSGESDtnISDTCLNELAPEKLLSSLLEAEPPNVYSlhPNKPYTEVSMMMSLTNLADRELVHMIAWAKKVPGFV
450 550 560 650 740 750 850
===|==========|=========| ===|=== ====|========|= ==|====
CONSENSUS ELSLLDQVRLLECCWLEVLMVGLMWRSIDHPGKLIFAPDLVLSRDEGKCVQGILEIFDMLLATTSRFRELKLQHEEYLCL
Q8BG65_MOUSE ELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLdrDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCV
ESR2_HUMAN ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV !
ESR2_MOUSE ELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFGMLLATTARFRELKLQHKEYLCV
ESR2_RAT ELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV
ESR2_CALJA ELSLLDQVRLLESCWLEVLMVGLMWRSIDHPGKLIFAPNLILDRDEGKCVEGILEVFDMLLATTSRFRELKLQHKEYLCV
ESR2_SHEEP ELSLYDQVRLLESCWLEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV
ESR2_BOVIN ELSLYDQVRLLESCWLEVLMVGLMWRSIDHPGKLIFAPDLILDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV
ESR2_PIG ELSLYDQVRLLESCWLEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV
Q90WS8_BRARE ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLSLSRDESSCVQGLVEIFDMLLAATSRFRELKLQREEYVCL
Q7ZU32_BRARE ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLCLSRDESSCVQGLVEIFDMLLAATSRFRELKLQREEYVCL
Q8AV62_BRARE ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLCLSRDESSCVQGLVEIFDMLLAATSRFRELKLQREEYVCL
Q98SM7_BRARE ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLCLSRDESSCVQGLVEIFDMLLAATSRFRELKLQREEYVCL
Q8JJB9_CYPCA ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLSLSRDEGSCVQGFVEIFDMLLAATSRFRELKLQREEYACL
ESR2_ONCMY ELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLSLSRDEGSCVQGFVEIFDMLLAATSRFRELKLQREEYVCL
ESRB1_CARAU EIGLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLVFSPDLSLSRDEGSCVQGFAEIFDMLLAATSRFRELKLQREEYACL
Q91Z86_MOUSE ELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLdrDEGKCVEGILEIFGMLLATTARFRELKLQHKEYLCV
ESR2_STUVU DLSLYDQVRLLESCWMEVLMIGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLAMTSRFRELKLQHKEYLCV
Q95MF0_MACAR ELSLFDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCV
Q6XSH2_MICSA DLSLADQIHLLKCCWLEILMLGLMWRSVDYPGKLIFSPDFKLNREEGQCVEGFMEIFDMLLAATSRFRELKLQREEYVCL
ESR2_MICUN ELSLADQINLLKCCWLEILMLGLMWRSVDHPGKLIFSPDFKLNREEGQCVEGIMEIFDMLLAGTSRFRELKLQREEYVCL
ESR2_ANGJA ELDLSDQVHLLECCWLEVLMLGLMWRSVDHPGKLIFSPDLKLNRDEGSCVEGILEIFDMVLAATSRFRELKLQREEYVCL
Q8QHK9_PAROL ELGLLDQVHLLECCWLEVLMMGLMWRSVDHPGKLIFSPDLSLSREEGSCVQGFSEIFDMLIAATSRVRELKLQREEYVCL
Q6H9M5_SPAAU ELSLADQIHLLKCCWLEILMLGLMWRSVDHPGKLIFSPDFKLNREEGQCVEGIMEIFDMLLAATSRFRELKLQREEYVCL
Q6H9M4_SPAAU ELSLADQIHLLKCCWLEILMLGLMWRSVDHPGKLIFSPDFKLNREEGQCVEGIMEIFDMLLAATSRFRELKLQREEYVCL
Q6XSH1_MICSA ELGLLDQVHLLECCWLEVLMVGLMWRSVDHPGKLIFSRDLSLSREEGSCVQGFAEIFDMLIAATSRVRELKLQREEYVCL
Q5PR29_BRARE ELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFTPDLKLNREEGNCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q98SM8_BRARE ELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFTPDLKLNREEGNCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q90WS9_BRARE ELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFTPDLKLNREEGNCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q762D6_CONMY ELDLSDQVHLLECCWLELLMLGLMWRSVDHPGKLIFSPDLKLNRDEGSCVDGILEIFDMLLAATSRFRELKLQREEYVCL
ESR2_SPAAU ELGLLDQVHLLECCWLEVLMIGLMWRSVDHPGKLIFSPDLSLSREEGSCVQGFLEIFDMLIAATSRVRELKLQREEYVCL
Q7T3U4_9TELE ELTLSDQVHLLECCWLDILMLGQMWRSVDHPGKLMFSPDLKLNREEGNCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q95ME9_CALJA ELSLLDQVRLLESCWLEVLMVGLMWRSIDHPGKLIFAPNLILDRDEGKCVEGILEVFDMLLATTSRFRELKLQHKEYLCV
Q7T2K7_9LABR ELCLADQIHLLKCCWLEILMLGLMWRSVDHPGKLIFSPDFKLNREEGQCVEGIMEIFDMLLAATSRFRELKLQREEYVCL
ESR2_ORENI ELSLVDQVHLLECCWLEVLMIGLMWRSVDHPGKLIFCPDLSLSREEGSCVQGFVEIFDMLIAATTRVRELKLQREEYVCL
Q804Q7_ACASC ELGLLDQVHLLECCWLEVLMIGLMWRSVDHPGKLIFSPDLSLSREEGSCVQGFLEIFDMLIAATSRVRELKLQREEYVCL
ESRB2_CARAU ELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFSPDLKLNRDEGTCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q7T3U5_9TELE ELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFSPDLKLNRDEWNCVEGIMEIFDMLLATTSRFRELKLQREEYVCL
Q6R7S4_SALSA DLCLFDQVHLLECCWLEVLMLGLMWRSVGHPGRLIFSPDLSLNREEGSCVQGFVDIFDMLLAATSRFRELKLQREEYVCL
Q8UW75_ORYLA ELSLLDQVHLLECCWLEVLMMGLMWRSVGHPGKLIFSPDLSLSREEGSCVQGFVEIFDMLIAATSRVRELNLQREEYVCL
ESR3_MICUN ELGLLDQVHLLECCWLEVLMVGLMWRSVDHPGKLVFSPDLSLSREEGSCVQGFAEIFDMLLAATSRVRELKLQREEYVCL
ESR2_COTJA DLSLYDQVRLLESCWLEVLMIGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLAMTSRFRELKLQHKEYLCV
ESR2_CHICK DLSLYDQVRLLESCWMEVLMIGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLAMTSRFRELKLQHKEYLCV
ESR2_ICTPU ELSLAHQVQLLECCWLEVLMLGLMWRSIDHPGKLIFSLDLKLNRDEGNCVEGIMEIFDMLLAGSSRFRELKLQKEEYVCL
Q90ZE6_SQUAC ELDLHDQVQLLECCWLEVLMVGLMWRSIEYPGKLLFAPDLILDRDEGQCVEGILEIFDMLLAATSRFRDLKLQHEEYLCL
940 950 1040 1050 1060
===== ====|=========|======== ==|=========|=========|=
CONSENSUS KAMILLNSSMCLLSPATEEAESRRKLLHLLDAVTDALVWVIAKTGISFQQQSTRLAHLLMLLSHIRHASNKGMEHLHCMK
Q8BG65_MOUSE KAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
ESR2_HUMAN KAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
ESR2_MOUSE KAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
ESR2_RAT KAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
ESR2_CALJA KAMVLLNSQYDPLVTATQDAESSQKLAHLLNAVTDALVWVIAKSGFSSQQQSVRLANLLMLLSHIRHASNKGMEHLLSMK
ESR2_SHEEP KAMILLNSSMYPSATASQEADSGRKLTHLLNAVTDALVWVIAKSGMSSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
ESR2_BOVIN KAMILLNSSMYPSATAPQEADSGRKLTHLLNAVTDALVWVIAKSGMSSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
ESR2_PIG KAMILLNSSMYPSAAA.QEAESSRKLTHLLNAVTDALVWVIARSGISSQQQSVRLANLLMLLSHVRHASNKGTEHLLNMK
Q90WS8_BRARE KAMILLNSNMCLGSSEGGEdqSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q7ZU32_BRARE KAMILLNSNMCLGSSEGGEdqSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q8AV62_BRARE KAMILLNSNMCLGSSEGGEdqSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q98SM7_BRARE KAMILLNSNMCLGSSEGGEdqSRSKLLCVLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHQHCMK
Q8JJB9_CYPCA KAMILLNSNMCLSSAEgeELQSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHCMK
ESR2_ONCMY KAMILLNSNMCLSSSEgeELQRRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHLSNKGMDHLHCMK
ESRB1_CARAU KAMILLNSNMCLSSAEgeELQSRSKLLCLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSNKGMDHLHSMK
Q91Z86_MOUSE KAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
ESR2_STUVU KAMILLNSSMFPLSAE..EPESNRKLHHLLNVVTEALVWVIAKSGIPSQQQTTRLANLLMLLSHVRHASNKGMEHLLSMK
Q95MF0_MACAR KAMILLNSNMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARAEKASHSLTSF
Q6XSH2_MICSA KAMILLNSNLCTSSPQteELESRNKLLRLLDSVIDALVWAISKLGLSTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMK
ESR2_MICUN KAMILLNSNLCTSSPQteELESRNKLLRLLDSVIDALVWAISKMGLTTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMK
ESR2_ANGJA KAIILLNPNLCTTSSerEELESRNKLLHMLDSVTDALVWTIAKKGLTFQQQSARLAHLLMLLAHIRHLSNKGMEHLSNMK
Q8QHK9_PAROL KAMILLNSNMCLSSSEgeELHSRSKLLLLLDAVTDALVWAIAKTGLTFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q6H9M5_SPAAU KAMILLNSYLCTNSPEteELESRNKLLRLLDSVIDALVWAISKLGLTTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMK
Q6H9M4_SPAAU KAMILLNSYLCTNSPEteELESRNKLLRLLDSVIDALVWAISKLGLTTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMK
Q6XSH1_MICSA KAMILLNSNMCLSSSEgeELQSRSKLLRLLDAVTDALVWAIAKTGLTFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q5PR29_BRARE KAMILLNSNNCSSLPQTPEdeSRGKVLNLLDSVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMK
Q98SM8_BRARE KAMILLNSNNCSSLPQTPEdeSRGKVLNLLDSVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMK
Q90WS9_BRARE KAMILLNSNNCSSLPQTPEdeSRGKVLNLLDSVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMK
Q762D6_CONMY KAIILLNPNLC.SASAteETESRSKLLHMLDAVTDALVWTIAKRGLTFQQQSARLAHLLMLLAHIRHVSNKGMEHLSNMK
ESR2_SPAAU KAMILLNSNMCLSSSEgeELQSRSKLLRLLDAVTDALVWAIAKTGLTFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHGMK
Q7T3U4_9TELE KAMILLNSNNCSSLPQTPEdeSRRKVLRLLDSVTDALVWTISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSTMK
Q95ME9_CALJA KAMVLLNSQYDPLVTATQDAESSQKLAHLLNAVTDALVWVIAKSGFSSQQQSVRLANLLMLLSHIRHARAEKASHSLtmE
Q7T2K7_9LABR KAMILLNSNLCSSSPQTeeLESRNKLLRLLDSVIDALVWAISKLGLSTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMK
ESR2_ORENI KAMILLNSNMCLSSSdsEDLQSRSKLLRLLDAMTDALVLAIGKTGLTFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHCMK
Q804Q7_ACASC KAMILLNSNMCLSSSEgeELQSRSKLLHLLDAVTDALVWAIAKTGLTFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHGMK
ESRB2_CARAU KAMILLNSSNCSRLPQTPEdeSRGKVLRLLDSVTDALVWTISRTGLSSHQQSIRLAHLLMLLSHIRHLSNKGIEHLSTMK
Q7T3U5_9TELE KAMILLNSNNCSSLSQSPEdeSRGKVLRLLDSVTDALVWSISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSSMK
Q6R7S4_SALSA KAMILLNSNMCLSSSEgeELQSRSKLLRLLDAVTDALVWAIAKTGLSFQQQSARLAHLLMLLSHIRHVSNKGMDHLHCMK
Q8UW75_ORYLA KAMILLNSNMCLSSSEGgeLHSRSKLLCLLDAVTDALVWAIGKSGLNFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHCMK
ESR3_MICUN KAMILLNSNMCLSSSE.....SSSKLLRLLDAVTDALVSAIGKTVLSFRQQYTRLAHLLMLLSHIRHVSNKGMDHLHCMK
ESR2_COTJA KAMILLNSSMFPLSAE..EPESNRKLHHLLNVVTDALVWVIAKSGIPSQQQTTRLANLLMLLSHVRHASNKGMEHLLSMK
ESR2_CHICK KAMILLNSSMFPLSPE..EPESNRKLHHLLNVVTDALVWVIAKSGIPSQQQTTRLANLLMLLSHVRHASNKGMEHLLSMK
ESR2_ICTPU KALILLNSSMYMTSSACedLESRTKLLRLLDAVTDALVWAISRTGLSTQQQSARLAHLLMLLSHIRHLSNKGMEHLSSMK
Q90ZE6_SQUAC KAMVLLNSSMFPRSGVTEEHENREKLHKILDTITDTLIWCMSKSGIPPQQQATRLAHLLMLLSHIRHASNKGMEHLYSMK
1250
=====|==
CONSENSUS MKNMVPVYDLLLEMLDANILHGSRLPHSGPEAPPAEDSSQPEQSQSPSSQ
Q8BG65_MOUSE CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ..............................
ESR2_HUMAN CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ.............................. !
ESR2_MOUSE CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ..............................
ESR2_RAT CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ..............................
ESR2_CALJA CKNVVPVYDLLLEMMNAHVVRGCKSSITGSECSPAEDSKSTEGSQNPQSP..............................
ESR2_SHEEP CKNVVPVYDLLLEMLNAHTLRSNKPLVTRSERNLAEDSESKEGSQKPQAQ..............................
ESR2_BOVIN CKNVVPVYDLLLEMLNAHTLRGNKSLVTGSERNLVEDSESKEGSQKPQAQ..............................
ESR2_PIG CKNVVPVYDLLLEMLNAHTLRGNKSLVTGSERSRMEESESKEGSQKPQAQ..............................
Q90WS8_BRARE MKKMVPLYDLLLEMLDAHIMHSSRLSHSGPRAPAAHKDNKSVQEAFPCSS..............................
Q7ZU32_BRARE MKKMVPLYDLLLEMLDAHIMHSSRLSHSGPRAPAAHKDNKSVQEAFPCSS..............................
Q8AV62_BRARE MKKMAPLYDLLLEMLDAHIMHSSRLSHSGPRAPAAHKDNKSVQEAFPCSS..............................
Q98SM7_BRARE MKKMVPLYDLLLEMLDAHIMHSSRLSHSGPRAPAAHKDDKSVQEAFPCSS..............................
Q8JJB9_CYPCA MKKMVPLYDLLLEMLDAHIMHSSRLSHSGPRAAPAPKESKGVQEALTRTS..............................
ESR2_ONCMY MKKMVPLYDLLLEMLDAHIMHGSRLSHSGP.AP...KESTGVQEATLSVL..............................
ESRB1_CARAU MKKMVPLYDLLLEMLDAHIMHGSRLSHSGPQADPVPKESNCVQETFTCTS..............................
Q91Z86_MOUSE CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ..............................
ESR2_STUVU CKNVVPVYDLLLEMLNAHTLRGQRKpaTHPEFGPLEQME.PGESLRKGEP..............................
Q95MF0_MACAR ..GMEDGDTLLPEATDGSVTF...........................................................
Q6XSH2_MICSA RKNVVLVYDLLLEMLDANTSSSGSQPSSSPSSDTYSDQHQYPQPPSHLQP..............................
ESR2_MICUN RKNVVLVYDLLLEMLDANTSSGGSQPSSSPSSETYSDQHQYPQPPSHLHP..............................
ESR2_ANGJA RKNVVPLYDLLLEMLDANTMHSSRMSASYSSQPS.PWsaQSQPGPPPSCS..............................
Q8QHK9_PAROL MKNMVPLYDLLLEMLDAHIMHSSRLPHHASPQP..EFTDQGEVPARPGSS..............................
Q6H9M5_SPAAU RKNVVLVYDLLLEMLDANTTTSGSQASSSPTSETFPDQHQYPQAPSHLQP..............................
Q6H9M4_SPAAU RKNVVLVYDLLLEMLDANTTTSGSQASSSPTSETFPDQHQYPQAPSHLQP..............................
Q6XSH1_MICSA MKNMVPLYDLLLEMLDAHIMHSSRLSHQPTQQDAEDQREAPARPHSSGss..............................
Q5PR29_BRARE RKNVVLLYDLLLEMLDANTSQSSRMLEDRQQSPENLHTSRPQPDLKDSDQ..............................
Q98SM8_BRARE RKNVVLLYDLLLEMLDANTSQSSRMLEDRQQSPENLHTSRPQPDLKDSDQ..............................
Q90WS9_BRARE RKNVVLLYDLLLEMLDANASQSSRMLEDRQQSPENLHTSRPQPDLKDSDQ..............................
Q762D6_CONMY RKNLVPLYDLLLEMLDANTMHGTRMSESYSQPPPWPPTAQSQPSPQPSCS..............................
ESR2_SPAAU MKNMVPLYDLLLEMLDAHIMHSSRLPRRSPQQETVEQCDAPARPHSPGTS..............................
Q7T3U4_9TELE RKNVVLLYDLLLEMLDANTSQSSRMLAAHTEASLQSDT.qPaqEPWHSPQ..............................
Q95ME9_CALJA ......DGD.......................................................................
Q7T2K7_9LABR RKNVVLVYDLLLEMLDANTSSSGSssSSSPNSDSYSDLHQYPQHPSHLQP..............................
ESR2_ORENI MKNIVPLYDLLLEMLDAHIMHSSCLPHQPPQQDSKDQSEVPAPLHspSns..............................
Q804Q7_ACASC MKNMVPLYDLLLEMLDAHIMHSSRLPRRSPQQETGDQCDGPARPHSPGPS..............................
ESRB2_CARAU RKNVVLLYDLLLEMLDANTSQSSRMLAAHTKASLRMDttSKQQPakESNQ..............................
Q7T3U5_9TELE RKNVVLLYDLLLEMLDANTSQSSRMLVAHTEASLTTDLhrPQPAPRESDQ..............................
Q6R7S4_SALSA MKNVVPLYDLLLEMLDAHIMHSPRLPHQANSAGPCPEVSHPQPTTSAAAP..............................
Q8UW75_ORYLA MKNMVPLYDLLLEMLDAHIMHSSRLPRQPPPQDAADPTETSAQGQRScsS..............................
ESR3_MICUN MKNMVPLYDLLLEMLDAHIMHSSRLPRRSPEQEPEDQADAPAPPHSSGss..............................
ESR2_COTJA CKNVVPVYDLLLEMLNAHTLRGQRKS...PV..THPDFE..QVSHF...Q..............................
ESR2_CHICK CKNVVPVYDLLLEMLNAHTLRGQRKS...PV......TH.PEFEQVSHFQ..............................
ESR2_ICTPU RKNVVLLYDLLLEMLDANMAQSRHVSTSVCTDPVTPATstPLPPQLHssQ..............................
Q90ZE6_SQUAC CKNVVPFYDLLLEMLDAHVIYSRTKP...SD.D..HDCGQSKGDNL..................................