2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS MTMTLHTKASGVALLHQIQGTELETLSRPQLKIPLERMLPEESVGSGKVATFDFLEGATYDFAAATPAPTPLYSHSTLGY
ESR1_PIG MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYVDSSKPAVYNYPEGAAYDFNAAAAASAPVYGQSGLAY
ESR1_MESAU MTMTLHTKASGMALLHQIQGNELEPLSRPQLKMPLERALSEVYVDSSKPAMFNYPEGAAYEFNAAT.APAPVYGQTGIAY
ESR1_BOVIN MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYMDSSKPAVYNYPEGAAYDFNAAAPASAPVYGQSGLPY
Q8AYH0_COTJA MTMTLHTKASGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVESNKTGVFNYPEGATYDF....GTTAPVYGSTTLSY
ESR1_RAT MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEfaAAAGASAPVYGQSSITY
ESR1_MOUSE MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEfaAAAAASAPVYGQSGIAY !
ESR1_CHICK MTMTLHTKASGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVESNKTGVFNYPEGATYDF....GTTAPVYGSTTLSY
ESR1_HUMAN MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPY !
ESR1_POEGU ..MTLHTKTSGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVETNKTGVFNYPEGATYDF....GTTAPVYSSTTLSY
Q765N7_ALLMI MTMTLHTKTSGVTLLHQIQGTELETLSRPQLKIPLDRSLSEMYVESNKTGIFNYPEGTTYDFATA....APVYSSTSLSY
ESR1_HORSE MTMTLHTKASGMALLHQIQGNELETLNLPQFKIPLERPLGEVYVESSKPPVYDYPEGAAYDFNAAAAASASVYGQSGLAY
Q8UWB0_CAICR MTMTLHTKTSGVTLLHQIQGTELETLSRPQLKIPLDRSLSEMYVENNKTGIFNYPEGTTYDFATA....APVYSSTSLSY
Q6A4C2_DICLA PAQSRQHCGPVVRPRISPAgtELETLssPPLRAPLSDMYPEESRGSGGAATVDFLEG.TYDYAAPTPAPTPLYSHSTPGY
Q9DDZ4_MICSA PAQSKQPCGTVLRPRIGPAFTELETLssPPLRAPLSDMYPEESRGSGGGATVDFLEG.TYDYVAPTPVPTPLYSHS..GY
Q6W5G7_XENLA MTMPLPNKTTGVTFLHQIQSSELETLTRPPLKISLERPLGEMYVENNRTGIFNYPEGTTYDFAA...AAAPVYSSASLSY
ESR1_PAGMA .....................................MYPEDSRGSGGVATVDFLEG.TYDYAAPTPAPTPLYSHSTPGY
ESR1_XENLA MTMPLPNKTTGVTFLHQIQSSELETLTRPPLKISLERPLGEMYVENNRTGIFNYPEGTTYDFAA...AAAPVYSSASLSY
ESR1_SPAAU .....................................MYPEDSRVSGGVATVDFLEG.TYDYAAPTPAPTPLYSHSTPGY
Q8UWA9_CNEUN MTMTLHTKTSGVALLHQIQGSELEPLNRPQLKIPLERPISEMYVDSNKTGVFNYPEGATYDFSTA....APVYSSASLSY
Q804Q6_ACASC .....................................MYPEDSRVSGGVATVDFLEG.TYDYAAPTPAPTPLYSHSTPGY
Q7SZI0_FUNHE PVQSKEAFGPALRPRLSPASSELETLSPPRLPpsLGDMYPEESRGSGGVAAVDFLEG.TYDYATPTPAPTPLYSHSTTGY
ESR1_ORENI .....................................MYPEESRGSGGVATVDFLEG.TYDYAAPTPAPTPLYSHSTTGC
ESR1_ORYLA SVQIRQLFGPALRSRISPASSELETLSPPRLSppLGDMYPEESRGSGGVAAVDFLEG.TYDYAAPNPATTPLYSQSSTGY
Q800Q2_ZOAVI .....................................MYPEESRGSGGVTTVDFLEG.TYDYAAPTPAPTPLYSHSTPGF
Q6TGB3_HAPBU .....................................MYPEESRGSGGVATVDFLEG.SYDYAAPTPAPTPLYSHSTTGC
Q7T2K8_9LABR .....................................MYPEESRGSGGVGTVDFLEG.TYDYTAPTPAPTL.YSLSTQGY
Q8QHL0_PAROL .....................................MYPEESRGSGGAATVDFLEG.TYDYAAPTPAQTPLYSHSTSGY
ESR1_OREAU .....................................MYPEESRGSGGVATVDFLEG.LMTMTAPTPAPTPLYSHSTTGC
ESR1_ONCMY LVRQSHTQISKPLGAPLRSRTTLESHVISPPktPNSNMYPEETRGGGGAAAFNYLDG.GYDYTAPAQGPAPLYYSTT...
Q6W5G9_XENTR .....................................MLFFCLflSIPVASV.........FIAA..AAAPVYSSASLSY
ESR1_BRARE .....................................MYpeEHSAGGISSSVNYLDG.AYEYPNPtgTSSPAEPASV.GY
Q69F36_CARAU .....................................MYpeEHSVGGISSSVNYLDG.SYEFPNPtgTSSPAEPASV.GY
Q90WV1_CARAU .....................................MYpeEHSTGGISSSLNYLDG.AYDFSNlfGTSSPTEPASF.GY
ESR1_ICTPU .MSEEQARAEAPAGARQRRRSELEGYSVSLASLKLSPMYPEEEQrgGISSTAHYLDG.TFNY.....TTNPDATNSSVDY
Q5XXP1_9TELE .....................................MYpeEHSAEGISSSVNYLDG.AYEYPDPtgTTSPAEPLSV.GY
Q90WH6_CLAGA .MSGEQTRTEALAGAKQRRRSELEGYSASLASLKLSPMYPEEEQqgGMSSTAHYLDG.TFDY.....ASNPPNP.SVDYY
Q6W5G5_XENLA ................................................................................
Q6W5G6_XENLA ................................................................................
CONSENSUS YPASLADAFGPPSDGGLQSLGSVPPSPLVFLPSSPQLSPFLHHHSHQVPHYLENESSPVYRREAAPPAFYQPVSRERRQG
ESR1_PIG GPGSEAAAFGANGLGGFQPLNSVSPSPLVLLHPPPQLSPFLHPHGQQVPYYLENEPSGYAVREAGPPAFYRPNSDNRRQG
ESR1_MESAU GSGSEATAFGSNSLGLFPQLNSVSPSPLMLlpPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDSGPPAFYRSNSDNRRQS
ESR1_BOVIN GPGSEAAAFGANGLGAFPPLNSVSPSPLVLLHPPPqlSPFLHPHGQQVPYYLENESSGYAVREAGPPAYYRPNSDNRRQG
Q8AYH0_COTJA APTSE..SFGSSSLAGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENEQGSFGMRETAPPAFYRPSSDNRRHS
ESR1_RAT GPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQN !
ESR1_MOUSE GPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQN !
ESR1_CHICK APTSE..SFGSSSLAGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENEQGSFGMREAAPPAFYRPSSDNRRHS
ESR1_HUMAN GPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQG !
ESR1_POEGU APTSE..SFGSSSLAGFHSLNSVPPSPVVFLQTAPHWSPFIHHHSQQVPYYLENDQGSFGMREAAPPAFYRPNSDNRRHS
Q765N7_ALLMI APTSE..SYGSSSLGGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENDQSGFGMREAAPSTFYRPGADSRRQS
ESR1_HORSE GPGSEAAAFGANGLGGFPPLNSVSPSQLMLLHPPPQLSPYLHPPGQQVPYYLENEPSGYSVCEAGPQAFYRPNADNRRQG
Q8UWB0_CAICR APTSE..SYGSSSLGGFHSLNNVPPSPVVFLQTAPQLSPFVHHHSQQVPYYLENDQSGFGMREAASSTFYRPSADSRHQS
Q6A4C2_DICLA YSAPL.DAHGPPSDGSLQSLGSGPTSPLVFVPSSPRLSPFMHPPTH...HYLETTSTPVYRSSV..PSSQQPVSREDPCG
Q9DDZ4_MICSA YSAPL.DAQGPPSDGSLQSLGSGPTSPLVFVPSSPRLSPFMHPPSH...HYLETTSTPVYRSSV..LSSQQPVPREDQCA
Q6W5G7_XENLA AASSE..TFGSSSLTGLHTLNNVPPSPVVFLQT.PQLSPFIHHHGQQVPYYLESEQGTFAVREAAPPTFYRSSSDNRRQS
ESR1_PAGMA YSAPL.DAHGPPSDGSLQSLGSGPNSPLVFVPSSPRLSPFMHPPTH...HYLETTSTPVYRSSV..PSSQQSVSREDQCG
ESR1_XENLA AASSE..TFGSSSLTGLHTLNNVPPSPVVFLAKLPQLSPFIHHHGQQVPYYLESEQGTFAVREAAPPTFYRSSSDNRRQS
ESR1_SPAAU YSAPL.DAHGPPSDGSLQSLGSGPNSPLVFVPSSPHLSPFMQPANH...HYLETTSTPIY..SV..PSSQHSVSREDQCG
Q8UWA9_CNEUN ASTNE..SFGSGNLGGLHSLNNVPPSPVVFLQTAPQLSPFIHHHNQQVPYYLENEPSSSAMREAFPTAFYRPGSENRHHG
Q804Q6_ACASC YSAPL.DAHGPPSDGSLQSLGSGPNSPLVFVPSSPRLSPFMHPPTH...HYLETTSTPIYRSSV..PSSQHSASREDQCG
Q7SZI0_FUNHE YSAPL.DAQGPPSDGSLHSLGSGPTSPLVFVPTSPRLSLFMHAPSQ...HYLETASTPVYRSSH......QPASREDQCD
ESR1_ORENI YSAPL.DAHGPLSDGSLQSLGSGPTSPLVFVPSSPRLSPFMHPPSH...HYLETTSTPVYRSSH......QPVPREDQCG
ESR1_ORYLA YSAPL.ETNGPPSEGSLQSLGSGPTSPLVFVPSSPRLSPFMHPPSH...HYLETTSTPVYRSSH......QGASREDQCG
Q800Q2_ZOAVI YSAPL.DSHRPPSDGSLQSLGSGPTSPIVFVPSSPRLSPFLHPPSH...HYLETTSTHVY..SV..PSSQQSVSREDQCG
Q6TGB3_HAPBU YSAPL.DAHGPPSDGSLQSLGSGTTSPLVFVPSSPRLSPFMHPPSH...HYLETTSTPVYRSSH......QPVPRDDQCG
Q7T2K8_9LABR YSAAL.DTHGQPSDSSIQSLGSGPSSPLVFVPSSPRLSPFMHLPSH...HYLETSSTPVYRSSV..SSSQQSISREEHCG
Q8QHL0_PAROL YSAPL.DAHGPPSDGSRHSLGSGPTSPHVYVPSSPRLSPFMHPPSH...HYLETTATSVYRSS......QQPVTREDHCG
ESR1_OREAU YSAPL.DAHGPLSDGSLQSLGSGPTSPLVFVPSSPRLSPFMHPPSH...HYLETTSTPVYRSSH......QPVPREDQCG
ESR1_ONCMY ...PQ.DAHGPPSDGSMQSLGSSPTGPLVFVSssPQLSPFLHPPShsQSYYLETSSTPLYRSSV..VTNQLSASEEKLCI
Q6W5G9_XENTR AASSE..TFGSSSLTGLHTLNNVPPSPVVFLQT.PQLSPFIHHHGQQVPYYLESEQGTFAVREAAPPTFYRSSSDNRRQS
ESR1_BRARE YPAPP.....DPHEEHLQTLGGGSSSPLMFAPSSPQLSPYLSHHghQVSYYLDSSSSTVYRSSV.......VSSQQAAVG
Q69F36_CARAU YPAPP.DPHVPPVEEHLQSLG....SPRIFAPSSPQLSPYLSHPghQASYYLDTPSSSLYRSSVVSSQQAGGGLCEELCS
Q90WV1_CARAU YPAPP.DPHAPPAEEHLQNLGTGPGSPLMFAPSSPQLSPYLNHHghQVSYYLDSPSSTVYRSSV.......VCSQQAGVG
ESR1_ICTPU YsaPE......PQEENLQPLPNGSSSPPVFVPSSPQLSPFLGHPpqQVPYYLEPSGTSIYRSSVLASAGSRVesAPGRQD
Q5XXP1_9TELE FLAPT.DHHAPPVEEHMQTFSGESSSPLMFAPTSPQLSPYLSHHghQVSYYLDTSSSTVYRSSV.......VSSQQAGVG
Q90WH6_CLAGA SAAPDLQVAPEPQEENLQPLgnGSASPMVFVSSSPQLSPFLSHPpqQVPYYLEPSGTPVYRSSVLASAGSRVesATSRQD
Q6W5G5_XENLA ................................................................................
Q6W5G6_XENLA ................................................................................
D010 D020 D030 D040 D050
|=========|=========|=========|=========|======
CONSENSUS GRDRMSSAGEKGSGAFESAKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_PIG GRERLASTSDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_MESAU GRERLSSSSEKGSMAMESVKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_BOVIN GRERLASTSDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q8AYH0_COTJA IRERMSSASEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_RAT GRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_MOUSE GRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC !
ESR1_CHICK IRERMSSTNEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_HUMAN GRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC !
ESR1_POEGU IRERMSSANEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q765N7_ALLMI GRERMSSTSEKTSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_HORSE GRERLASSGDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q8UWB0_CAICR GRERMSSTSEKASLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q6A4C2_DICLA TSDDSYSVGESGAGafEMAKDMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q9DDZ4_MICSA TSDESYCVGESGAGafEMAKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q6W5G7_XENLA GRERMSSANDKGPPSMESTKETRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_PAGMA TSDDSYSVGESGAGafEIAKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
ESR1_XENLA GRERMSSANDKGPPSMESTKETRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_SPAAU TSDDSYSVGESGAGafEMAKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q8UWA9_CNEUN GR...ASNSEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q804Q6_ACASC TSDDSYSVGESGAGafEMAKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q7SZI0_FUNHE TRDEACSVGELGAGafEMAKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
ESR1_ORENI TRDEAYSVGELGAGafEMTKDTRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_ORYLA SREDTCSLGELGAGafEMAKDTRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q800Q2_ZOAVI TSDESYSLVESGAGafEMAKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q6TGB3_HAPBU TRDEAYGLGELGAGafEMTKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q7T2K8_9LABR TSDESYSMGESGAGafEMAKEMRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
Q8QHL0_PAROL PRDESFSVGETGAAafEMAKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDRNRRKSCQAC
ESR1_OREAU TRDEAYSVGELGAGafEITKNTRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_ONCMY ASDrsYSAAGSGVRVFEMANETRYCAVCSDFASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTMDRNRRKSCQAC
Q6W5G9_XENTR GRERMTSANDKGPPSMESTKETRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
ESR1_BRARE LCEELCSagSRAAGGFDSGKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
Q69F36_CARAU ASDrmYS.GSRGTGGFDSEKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
Q90WV1_CARAU LCEELCSAAdsGsgGFDSEKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
ESR1_ICTPU VYTagAS.GPSGagAIGLVKEIRYCSVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
Q5XXP1_9TELE LCEVLCSagSRAAGGFDSEKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
Q90WH6_CLAGA VYTAvaS.RPSGagAIGLVKEIRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQAC
Q6W5G5_XENLA ....MSSANDKGPPSMESTKETRYCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
Q6W5G6_XENLA ....MSSANDKGPPSMESTKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
D060 140
===|====== ===|=======
CONSENSUS RLRKCYEVGMMKGGIRKDRRGGRVLKHKKQREEQEDRNKASKSLEHRTAPPQDSPSSISHGKGNSSVLSMPPDQVLLLLL
ESR1_PIG RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPPGDMRSANLWPSPLLIKHTKKNSPVLSLTADQMISALL
ESR1_MESAU RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNDMGPSGDMRATNLWPSPLVIKHTKKNSPALSLTADQMVSALL
ESR1_BOVIN RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPSGDMRAANLWPSPIMIKHTKKNSPVLSLTADQMISALL
Q8AYH0_COTJA RLRKCYEVGMMKGGIRKDRRGGRMMKQKRQREEQESRNGEASSTELRAPTLWTSPLVVKHNKKNSPALSLTAEQMVSALL
ESR1_RAT RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALL
ESR1_MOUSE RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALL !
ESR1_CHICK RLRKCYEVGMMKGGIRKDRRGGEMMKQKRQREEQDSRNGEASSTELRAPTLWTSPLVVKHNKKNSPALSLTAEQMVSALL
ESR1_HUMAN RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALL !
ESR1_POEGU RLRKCYEVGMMKGGIRKDRRGGRVMKQKRQREEQDSRNGEASSTELRAPTLWASPLVVKHNKKNSPALSLTAEQMVSALL
Q765N7_ALLMI RLRKCYEVGMMKGGIRKDRRGGRMLKQKRQREEQDARNGETATAEMRTPTLWTSPLVIKHTKKNSPALSLTAEQMVSALL
ESR1_HORSE RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAGPSGDRRPANFWPSPLLIKHTKKISPVLSLTAEQMISALL
Q8UWB0_CAICR RLRKCYEVGMMKGGIRKDRRGGRMLKQKRQREEQDARNGETATAEMRTPTLWTSPLVIKHTKKNSPALSLTAEQMVSALL
Q6A4C2_DICLA RLRKCYEVGMMKGGVRKDR..GRVLRRDKRRTRAGDKEKASKDLEHRTVPPQdsSSSSSsgGGKSSMIGMPPEQVLLLLQ
Q9DDZ4_MICSA RLRKCYEVGMMKGGVRKDR..GRVLRRDKRRAGTNDRDKASKDLEYRTVPPQdsSSSAGGGGGKSSVTGMSPDQVLLLLQ
Q6W5G7_XENLA RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQKEEQEQKNDVDPS.EIRTASIWVNPSVKS..MKLSPVLSLTAEQLISALM
ESR1_PAGMA RLRKCYEVGMMKGGMRKDR..GRVLRRDKQRTGTSDRDKASKGLEHRTAPPQdiSSSAGGGGGKSSMISMPPDQVLLLLQ
ESR1_XENLA RLRKCYEVGMMKGGIRKDRRGGRLLKHKRQKEEQEQKNDVDPS.EIRTASIWVNPSVKS..MKLSPVLSLTAEQLISALM
ESR1_SPAAU RLRKCYEVGMMKGGVRKDR..GRVLRRDKRRTGTSDRDKASKGLEHRTAPPQdiSSSAGGGGGKSSVISMPPDQVLLLLR
Q8UWA9_CNEUN RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDELDGRNAV.AVTEARNTTLWPSPLMIKHSKKNSPALSLTAEQMVSALL
Q804Q6_ACASC RLRKCYEVGMMKGGVRKDR..GRVLRRDKRRTGTSDRDKASKGLEHRTAPPQdiSSSAAGGGGKSSVISMPPDQVLLLLQ
Q7SZI0_FUNHE RLRKCYEVGMMKGGVRKER..GRVLRRDKRRTAISDREKAVKGLEPKTSPHQDKRKRGSALGgrSSVASLPSEQVLLLFQ
ESR1_ORENI RLRKCYEVGMMKGGMRKDR..GRVLRREKRRAC..DRDKPAKDLPHTRASPQdsSSSTSGGGGRSSLNNMPPDQVLLLLQ
ESR1_ORYLA RLRKCYEVGMMKGGVRKDR..IRILRRDKRRTGVGDGDKVVKGQEHKTV.HYDGRKRSsgGGGRLSVTSIPPEQVLLLLQ
Q800Q2_ZOAVI RLRKCYEVGMMKGGVRKDR..GHVLRRDKRRSDLSDRDKASKDLEHRTVPSQdkRSSISsvGGKSMLTSMPPDQVLLLLQ
Q6TGB3_HAPBU RLRKCYEVGMMKGGMRKDR..GRVLRREKRRAY..DRDKPAKDLPHTKAPPHdsSSSTSGGGGRSSLNSIPPDQVLLLLQ
Q7T2K8_9LABR RLRKCYEVGMMKGGVRKDR..GRVLRRDKRRTGTSDKDNGSKDREQRTVPPQGRRKHGSsgGGKSPVISMPPDQVLLLLQ
Q8QHL0_PAROL RLRKCYEVGMMKGGVRKDR..SHVLRRDKRRAGTNDRDKASKDQDHKTVPLQDGRKSSSsaGGKSSVTAMLPDQVLVLLQ
ESR1_OREAU RLRKCYEVGMMKGGMRKDR..GRVLRRerQTSQNLPTHKASP.QDGRKR..AMSSSSTSGPGGRSSLNNMPPDQVLLLLQ
ESR1_ONCMY RLRKCYEVGMVKGGLRKDR.GGRVLRKDKRYCGpgDREKPYGDLEHRTAPPQdsSSSLNGGGgrGPRITMPPEQVLFLLQ
Q6W5G9_XENTR RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQKEEQEQKNDVTPS.EIRTTSIWVNPSVKS..MKLSPVLSLTAEQLISALM
ESR1_BRARE RLRKCYEVGMMKGGIRKDR.GGRSVRRERRRSSNEDRDKSSSDQC.rTTGPQDKRK..KRSGGVVSTLCMSPDQVLLLLL
Q69F36_CARAU RLRKCYEVGMVKGGIRKDR.GGRAIRRERRRSGNEDLIKSYSEQSsrTAPPQDKRK.KSSGGG.VSALCLPPDQVLLLLL
Q90WV1_CARAU RLRKCYEVGMMKGGIRKER.GGRAIRRDRRRSGNEDRVKSYSEqgLRTAPPQDRRKSSS..TGVVSTLCMPPDQVLVLLL
ESR1_ICTPU RLRKCYEVGMMKGGFRKER.GGRIIKHNRRPSGLKERekAQSGSDVREALPQDGQSSSGIGGGVADVVCMSPEQVLLLLL
Q5XXP1_9TELE RLRKCYEVGMMKGGIRKDR.GGRAIRRERRKSDNEDRDKSYSEQSSRVgtPQDKRKKSS..AEVVSALCMPPDQVLVLLL
Q90WH6_CLAGA RLRKCYEVGMMKGGYRKER.GGRAMKHSRRHGGlrGYNEAQSGSDAREAPPQDGRSTSGIGSAVAGVVCMAPEQVLLLLL
Q6W5G5_XENLA RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQKEEQEQKNDVDPS.EIRTASIWVNPSVKS..MKLSPVLSLTAEQLISALM
Q6W5G6_XENLA RLRKCYEVGMMKGGIRKDRRGGRMLKHKQQKEEPEQKNDVNPS.EIRTASIWVNPSVKS..MKLSPVLSLTAEQLISALM
150 330 340 350 450 550 560
==|====== ==|=========|=========|=== ===|==========|=========|
CONSENSUS GAEPPILCSRYKPSRPFSEATMMTLLTNMADKELVHMIAWAKKVPGFLQLSLHDQVQLLESSWLEILMIGLIWRSIECPG
ESR1_PIG EAEPPIIYSEYDPTRPLSEASMMGLLTNLADRELVHMINWAKRVPGFLDLSLHDQVHLLECAWLEILMIGLVWRSMEHPG !
ESR1_MESAU DAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLIWRSMEHPG
ESR1_BOVIN EAEPPIIYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLALHDQVHLLECAWLEILMIGLVWRSMEHPG
Q8AYH0_COTJA EAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
ESR1_RAT DAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPG
ESR1_MOUSE DAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPG !
ESR1_CHICK EAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
ESR1_HUMAN DAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG !
ESR1_POEGU EAEPPLVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
Q765N7_ALLMI EAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSVEHPG
ESR1_HORSE DAEPPVLYSEYDATRPFNEASMMGLLTNLADRELVHMINWAKRVPGFVDLSLHDQVHLLECAWLEILMIGLVWRSMEHPG
Q8UWB0_CAICR EAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
Q6A4C2_DICLA GAEPPMLCSRQKLSRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q9DDZ4_MICSA GAEPPMLCSRQKLSRPYTEVTIMTLLTSMADKELVHMITWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q6W5G7_XENLA EAEPPIVYSEHDSTKPLSEASMMTLLTNLADKELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG
ESR1_PAGMA GAEPPMLCSRQKLNRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
ESR1_XENLA EAEAPIVYSEHDSTKPLSEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG
ESR1_SPAAU GAEPPMLCSRQKVNRPYTEVTVMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q8UWA9_CNEUN DAEPPIVYSEYDPSSPFSEASVMTLLTNLADRELVHMITWAKRVPGFVDLALHDQVHLLECAWLEILMIGLIWRSLEHPG
Q804Q6_ACASC GAEPPMLCSRQKVNRPYTEVTVMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q7SZI0_FUNHE GAEPPILCSRQKLSRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLALHDQVLLLESSWLEVLMIGLIWRSIHCPG
ESR1_ORENI GAEPPILSSRQKMSRPYTEVTIMTLLTSMADKELVHMITWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSIQCPG
ESR1_ORYLA GAEPPILCSRQKLSRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSIHCPG
Q800Q2_ZOAVI CAEPPILCSRQKLSRPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLGLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q6TGB3_HAPBU GAEPPTLCSRQKMNQPYTEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSIHCPG
Q7T2K8_9LABR GAEPPILCSRQKLSRPYTEVTMMTLLTSMTDRELVHMIAWAKKLPGFLQLTLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q8QHL0_PAROL GAEPPILCSRQKLNQPYTEVTMMTLLTSMADRELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
ESR1_OREAU GAEPPILCSRQKMSRPYTEVTIMTLLTSMADKELVHMITWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSIQCPG
ESR1_ONCMY GAEPPALCSRQKVARPYTEVTMMTLLTSMADKELVHMIAWAKKVPGFQELSLHDQVQLLESSWLEVLMIGLIWRSIHCPG
Q6W5G9_XENTR EAEPPIVYSEHDSTKPLSEASMMTLLTNLADKELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG
ESR1_BRARE GAEPPAVCSRQKHSRPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPG
Q69F36_CARAU EAEPPAVCSRQKHSRPFTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPG
Q90WV1_CARAU GAEPPAVCSRQKHSRPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDKVQLLESTWLEVLMIGLIWRSIHSPG
ESR1_ICTPU RAEPPTLCSRQKHSRPYSELTIMSLLTNMADRELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEILMIGLIWRSIYTPG
Q5XXP1_9TELE GAEPPAVCSRQKHSPPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPG
Q90WH6_CLAGA RAEPPTLSSRQKLSRPYSELTIMSLLTNMADRELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEILMIGLIWRSIHSPG
Q6W5G5_XENLA EAEPPIVYSEHDSTKPLSEASMMTLLTNLADKELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG
Q6W5G6_XENLA EAEPPIVYSEHDSTKPLSEASMMTLLTNLADKELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPE
650 740 750 850 940
===|=== ====|========|= ==|========= ====|====
CONSENSUS KLLFAPDLILDRNEGKCVEGMAEIFDMLLATVSRFRMLKLKGEEFVCLKAIILLNSGAFSFLTGTMEPLHEKDAVQRMLD
ESR1_PIG KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
ESR1_MESAU KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSARFRMMDLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
ESR1_BOVIN KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLRSLEEKDHIHRVLD
Q8AYH0_COTJA KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEERDYIHRVLD
ESR1_RAT KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
ESR1_MOUSE KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
ESR1_CHICK KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEERDYIHRVLD
ESR1_HUMAN KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD !
ESR1_POEGU KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDYIHRVLD
Q765N7_ALLMI KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDYIHRVLD
ESR1_HORSE KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRLRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
Q8UWB0_CAICR KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDYIHRVLD
Q6A4C2_DICLA KLIFAQDLILDRSEGDCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDTAAVQNMLD
Q9DDZ4_MICSA KLIFAQDLILDRNEGDCVEGFVEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHNSVEVHNMLD
Q6W5G7_XENLA KLSFAPNLLLDRNQGRCVEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIILLNSGVYTFLSSTLESLEDTDLIHIILD
ESR1_PAGMA KLIFAQDLILDRSEGDCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDGAAVQNMLD
ESR1_XENLA KLSFAPNLLLDRNQGRCVEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIILLNSGVYTFLSSTLESLEDTDLIHIILD
ESR1_SPAAU KLIFAQDLILDRSEGDCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDSAAVQNMLD
Q8UWA9_CNEUN KLLFAPNLLLDRSQGMCVEGFVEIFDMLLATSSRFRMMNIQGEEFVCLKSIILLNSGIYTFLSSTLRSLEEKEHIHRVLD
Q804Q6_ACASC KFIFAQDFILDRSEGDCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIVLLNSGAFSFCTGTMEPLHDGAAVQNMLD
Q7SZI0_FUNHE KLIFAQDLILDRNEGDCVEGMTEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDSVAVQNMLD
ESR1_ORENI KLIFAQDLILDRNEGTCVEGMAEIFDMLLATASRFRVLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDSAAVQHMLD
ESR1_ORYLA KLIFAQDLILDRNEGDCVEGMTEIFDMLLATASRFRVLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHNSAAVQSMLD
Q800Q2_ZOAVI KLIFAQDLILDRNEGDCVEGMAEIFDMLLATTSRFRLLKLKPEEFVCLKAIILLNSGAFSFCTATMEPLHDTAAVQHMLD
Q6TGB3_HAPBU KLIFAQDLILDRTEGTCVEGMAEIFDMLLATASRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDSAAVQHMLD
Q7T2K8_9LABR KLIFAQDLILDRSEGDCVEGMAEIFDMLLATTSRFRMLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDNEAVQNMLD
Q8QHL0_PAROL KLIFAQDLILDRNEGNCVEGMAEIFDMLLATASRFRMLKLKSEEFFCLKAIILLNSGSFSFCTGTMEPLHNTAAVQDMLE
ESR1_OREAU KLIFEEDLILDRNEGTCVEGMAEIFDMLLATV.RFRVLKLKPEEFVCLKAIILLNSGAFSFCTGTMEPLHDSVAVQHMLD
ESR1_ONCMY KLIFAQDLILDRSEGDCVEGMAEIFDMLLATVSRFRMLKLKPEEFVCLKAIILLNSGAFSFCSNSVESLHNSSAVESMLD
Q6W5G9_XENTR KLSFAPNLLLDRNQGRCVEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIILLNSGVYTFLSSTLESLEDTDLIHIILD
ESR1_BRARE KLIFAQDLILDRSEGECVEGMAEIFDMLLATVARFRSLKLKLEEFVCLKAIILINSGAFSFCSSPVEPLMDNFMVQCMLD
Q69F36_CARAU KLIFAQDLILDRSEGECVEGMTEIFDMLLATVARFRSLKLKLEEFVCLKAIILLNSGAFSFCSSSVEPLMDSFMVQCMLD
Q90WV1_CARAU KLIFAQDLILDRNEGECVEGMAEIFDMLLATVTRFRSLKLKLEEFVCLKALILLNSGAFSFCSSPVEPLMDSFMVQCMLD
ESR1_ICTPU KLIFAQDLILDKSEGECVEGMAEIFDMLLATVARFRTLKLKSEEFVCLKAIILLNSGAFSFCSSPVEPLRDGFMVQCMMD
Q5XXP1_9TELE KLIFAQDLILDRNEGECVEGMAEIFDMLLATVARLRSLKLKLEEFVCLKAIILLNSGAFSFCSSPVEPLMDSFMVQCMLD
Q90WH6_CLAGA KLIFAQDLILDRTEGECVEGMAEIFDMLLATVARFRALKLKSEEFVCLKAIILLNSSAFSFYSSPVEPLRDGFMVQCMMD
Q6W5G5_XENLA KLSFAPNLLLDRNQGRCVEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIILLNSGVYTFLSSTLESLEDTDLIHIILD
Q6W5G6_XENLA KLSFAPNLLLDRNQGRCVEGLVEIFDMLVTTATRFRMMRLHGEEFICLKSIILLNSGVYTFLSSTLESLEDTDLIHIILD
950 1040 1050 1060 1250
=====|======== ==|=========|=========|= =====|==
CONSENSUS KITDALIHLISKSGCSLQQQHRRQAQLLLLLSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPARPAQSQS
ESR1_PIG KITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPTNLGGPPP
ESR1_MESAU KITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPFYDLLLEMLDAHRLHTPVSRMGVSP
ESR1_BOVIN KITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPANFGSAPP
Q8AYH0_COTJA KITDTLIHFMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPM
ESR1_RAT KINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPP !
ESR1_MOUSE KITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPP !
ESR1_CHICK KITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPM
ESR1_HUMAN KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASV !
ESR1_POEGU KITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPM
Q765N7_ALLMI KITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARNAAQV
ESR1_HORSE KMTDTLIHLMAKAGLTLQ.QHRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPANHGGAPM
Q8UWB0_CAICR KITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARNAAQV
Q6A4C2_DICLA TITDALIHHISQSGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIQRPDRPAQSWS
Q9DDZ4_MICSA TITDALIHHISQSGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIHRPDRPAQFWS
Q6W5G7_XENLA KIIDTLVHFMAKSGLSLQQQQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRIHTPKDKTTTQ.
ESR1_PAGMA TITDALIHHINQSGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIHRADRPAETWS
ESR1_XENLA KIIDTLVHFMAKSGLSLQQQQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRIHTPKDKTTTQ.
ESR1_SPAAU TITDALIHHINQSGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRVHRPDRPAETWS
Q8UWA9_CNEUN KITDTLTHLMAKSGLSLQQQHRRLAQLLLMLSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLH..ERRTPTSE
Q804Q6_ACASC TITDALIHHINQSGCTAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRVHRPDRPHETWS
Q7SZI0_FUNHE TITDALIHHISQSGFSVQQQARRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRHH.PVKP..SQ.
ESR1_ORENI TITDALIFHISHLGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIHRPVKPFQSWS
ESR1_ORYLA TITDALIHYISQSGYLAQEQARRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRLHHPVRAPQSLS
Q800Q2_ZOAVI TITDTLIHHIGQSGCSVQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRLHRPDKPGESWF
Q6TGB3_HAPBU TITDALIFHISQLGCSAQHQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAQRIHRPVKPSQSWS
Q7T2K8_9LABR IITDALIHHISQSGCSAHQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRLHRPDRPAESWY
Q8QHL0_PAROL TITDALIHHISQSGCPVQQQWRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHCLHRPARPAQSWL
ESR1_OREAU TITDALIFHISHFGCSAQQQSRRQAQLLLLLSHIRHMSNKGMEHLYSMKCKNKVPLYDLLLEMLDAHRIHRPVKPSQSWS
ESR1_ONCMY NITDALIHHISHSGASVQQQPRRQAQLLLLLSHIRHMSNKGMEHLYSIKCKNKVPLYDLLLEMLDGHRLQSPGKVAQAGE
Q6W5G9_XENTR KIIDTLVHFMAKSGLSLQQQQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRMHTPKDKATAQ.
ESR1_BRARE NITDALIYCISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQRFQSSGKV.qsQS
Q69F36_CARAU NITDALIYCISKSGATPQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQQFHSS.RKVqsQS
Q90WV1_CARAU NITDAFIYGISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQRFHSSGKV.qaQS
ESR1_ICTPU NITDALIYYISQSGISVQLQSRRQAQLLLLLSHIRHMSYKGMEHLYSMKCKNKVPLYDLLLEMLDAHRLR.PlkVPRIW.
Q5XXP1_9TELE NITDALIYGISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYHMKCKNRVPLYDLLLEMLDAQRFQSPGEVqgAQS
Q90WH6_CLAGA NITDALVHYISQSGIPVQLQSRRQAQLLLLLSHIRHMSYKGMEHLYNMKCKNKVPLYDLLLEMLDAHRLR.PLGKV.SKS
Q6W5G5_XENLA KIIDTLVHFMAKSGLSLQQQQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRIHTPKDKTTTQ.
Q6W5G6_XENLA KIIDTLVHFMAKSGLSLQQQQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRIHTPKDKTTTQ.
CONSENSUS EEDSRSPLTTSSNTSSSSLQGYYSSAGSSSGPNTI
ESR1_PIG EDMSQSQLATSGSTPSHSLQMYYITGEAENFPTTI.............................................
ESR1_MESAU EEPSQSQLTTTNSTSSHSLQTYYIPSEAESFPNTI.............................................
ESR1_BOVIN EDVNQSQLAPTGCTSSHSLQTYYITGEAENFPSTV.............................................
Q8AYH0_COTJA EEENRSQLTTAPASSHSLQSFYINSKEEESMQNTI.............................................
ESR1_RAT EEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI.............................................
ESR1_MOUSE EEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI............................................. !
ESR1_CHICK EEENRNQLTTAPASSHSLQSFYINSKEEESMQNTI.............................................
ESR1_HUMAN EETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV............................................. !
ESR1_POEGU EEENRSQLTTASASSHSLQSFYINSKEEENMQNTL.............................................
Q765N7_ALLMI EEE..TRLTTASASSHSLQSFYINNREDENLQNTI.............................................
ESR1_HORSE EETNQSQLATTGSTSPHSMQTYYITGEAEGFPNTI.............................................
Q8UWB0_CAICR EEE..TRLTTASASSHSLQSFYINNREDENLQNTI.............................................
Q6A4C2_DICLA QADG.EPptTNNNNNNISGGGSTSSAGSSSGPRVS.............................................
Q9DDZ4_MICSA QADGEPPFITVNNCNSSSNGGVSSSVGSSSGPRVS.............................................
Q6W5G7_XENLA EEDSRSPPTTTVNGASPCLQPYYTNTEEVSLQSTV.............................................
ESR1_PAGMA QAD.REPPFTSRNSSGGGGggGSSSAGSTSGPRVS.............................................
ESR1_XENLA EEDSRSPPTTTVNGASPCLQPYYTNTEEVSLQSTV.............................................
ESR1_SPAAU QAD.REPLFTSRNSSSSSGGggSSSAGSTSGPQVN.............................................
Q8UWA9_CNEUN QAMN..QLTNAS.TSVHSLPPCynKREEENEQEAV.............................................
Q804Q6_ACASC QAD.REPPFTSRNNRGSGGGGGSSSAGSTSGTRVS.............................................
Q7SZI0_FUNHE ..DGKSPPSTSSFGAGCEGG..SSSAGSSSGPRGS.............................................
ESR1_ORENI QGDRDSP..TASSTSSSGGGggASSAGSSSGPQGS.............................................
ESR1_ORYLA QVD.RDPPSTSSGGGGIAPGSISASRgiES.PSRG.............................................
Q800Q2_ZOAVI PADGETLCTTSDnsSGGSGSGPRVSHDSPSRAPTV.............................................
Q6TGB3_HAPBU QGDRDSP.NTSSSGGGGSDDEGTSSAGSSSGPQGN.............................................
Q7T2K8_9LABR QTdySSSATTTNDNSSSSPAGSRASQESPNRPPTG.............................................
Q8QHL0_PAROL QAdnSSSIIISGGGSSSASSGHRGSQESPSRATTG.............................................
ESR1_OREAU QGDRDSP..TASSTSSRGGGGGD.sAGSSSGPQGS.............................................
ESR1_ONCMY QTEGPSTTTTTSTGSSisQDTHIRSPGssSDQMPI.............................................
Q6W5G9_XENTR EEDSRSPLTTTANGASPCLQPFYTSTEEVSLQSTV.............................................
ESR1_BRARE EKNPPSTPTTSSSSSNNSPRGGA.AAIQSNGACHS.............................................
Q69F36_CARAU EKDSWSTP.TAGSSSPSRGPGAMQPngTesLcnTL.............................................
Q90WV1_CARAU EKDPPSTPTTSSRGPGTML.PNIACHEQSPDP................................................
ESR1_ICTPU .AdsSSPTTTanTTTTTTTTTHHPSNGssNpqSPS.............................................
Q5XXP1_9TELE EKDPPSTPPTRGPGAT...QP...NTGCLS.QSPD.............................................
Q90WH6_CLAGA WADRVSNmtTTTTTNQQSSAPPCPADLPSNPPCTN.............................................
Q6W5G5_XENLA EEDSRSPPTTTVNGASPCLQPYYTNTEEVSLQSTV.............................................
Q6W5G6_XENLA EEESRSPLSTTVNGASPCLQPFYKNTEEVSLQSTV.............................................