2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
D010 D020
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CONSENSUS MAMVTGGWGDPGGDTNGVDKAGGYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF
EAR2_HUMAN MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF
Q922G8_MOUSE MAMVTGGWGDPGGDTNGVDKAGgyPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF
EAR2_MOUSE MAMVTGGWGDPGGDTNGVDKAGgyPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF
EAR2_RAT MAMVTGGWGGPGGDTNGVDKAGgyPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF
Q6GL59_XENTR MAMVSGGWGDPNGDTNGVGK..GYPRNSEEEEASPQGGMSDPEQGDEERPGIQVDCVVCGDKSSGKHYGVFTCEGCKSFF
Q7T0T7_XENLA MAMVSGGWGDPNGDTNGVGK..GYPRNSEEEEASPQGGMSDPEQGDEERPGIQVDCVVCGDKSSGKHYGVFTCEGCKSFF
Q6P117_BRARE MAMVRGGWGDPNGETNGldK..GYLRGDEDD.GSPQGGGSDMEAG.EDDKGCVVDCVVCGDKSSGKHYGVFTCEGCKSFF
Q6P115_BRARE MAMVSGGWANPNGSANGLgk..GYLRG.EEEGSSPQAGNSDVE.GGEEDKACVVDCVVCGDKSSGKHYGVFTCEGCKSFF
D030 D040 D050 D060
====|=========|=========|=========|======
CONSENSUS KRTIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPGHSAASPTSPPGDAGAGNATGVEP
EAR2_HUMAN KRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDL
Q922G8_MOUSE KRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPG.PAAC..SPPG......ATGVEP
EAR2_MOUSE KRTIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPG.PAAC..SPPG......ATGVEP
EAR2_RAT KRTIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQPGPIPHALPG.PAAC..SPPG......AAGVEP
Q6GL59_XENTR KRSVRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIP...PAHSSASPTSAPG......A.G.EY
Q7T0T7_XENLA KRSVRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIP...PAHSSASPTSAPG......A.G.EY
Q6P117_BRARE KRSVRRNLNYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIP...PSHSSLSPstPVG....GNA.GgeF
Q6P115_BRARE KRSIRRNLNYTCRSNRECQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPPSHAGISPASMVGAGGDVGGGPGMGADF
140 150 330 340 350 450 550
===|=========|====== ==|=========|=========|=== ===|==========|
CONSENSUS FNGPPVSELIAQLLRAEPYPAAGYRFQYGGGYQGAVLGIDNVCELAARLLFSTVEWARHAPFPELPAADQVALLRLSWSE
EAR2_HUMAN FPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHApfPELPVADQVALLRLSWSE
Q922G8_MOUSE FTGPPVSELIAQLLRAEPYPAAG.RF..GGG..GAVLGIDNVCELAARLLFSTVEWARHApfPELPAADQVALLRLSWSE
EAR2_MOUSE FTGPPVSELIAQLLRAEPYPAAG.RF..GGG..GAVLGIDNVCELAARLLFSTVEWARHApfPELPAADQVALLRLSWSE
EAR2_RAT FAGPPVSELIAQLLRAEPYPAAG.RF..GGG..GAVLGIDNVCELAARLLFSTVEWARHApfPELPAADQVGLLRLSWSE
Q6GL59_XENTR FNGQPVSELISQLLRAEPYPASR....YGSQYagSVMGIDNICELAARLLFSTVEWSRNIpfPELAMADQVSLLRLSWSE
Q7T0T7_XENLA FNGQPVSELISQLLRAEPYPASR....YGSQ.qGSVMGIDNICELAARLLFSTVEWSRSIpfPELAVADQVSLLRLSWSE
Q6P117_BRARE YNGQPVSELISQLLRAEPYPNSRYSHqqGGGGGGSGMGIDSICELAARLLFSIIEWARNIpfPELPVSEQVALLRLSWSE
Q6P115_BRARE FNGQPVSELISQLLRAEPYPNSRYGAQCGQQLQgsMMGIDNICELAARLLFSTIEWARNIpfPDLPVSEQVALLRLSWSE
560 650 740 750 850
=========| ===|=== ====|=========|= ==|========= =
CONSENSUS LFVLNAAQAALPLHTAPLLAAAGFHASPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDP
EAR2_HUMAN LFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDP
Q922G8_MOUSE LFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDP
EAR2_MOUSE LFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDP
EAR2_RAT LFVLNAAQAPVPLHTAPLLAAAGLHAGPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDP
Q6GL59_XENTR LFVLSAAQSALPLHMAPLLAAAGFHASPMSADRVVSFMDQIRLFQDQVEKLNRLQVDSAEYACLKAIALFTSDACGLTDP
Q7T0T7_XENLA LFVLSAAQSALPLHMAPLLAAAGFHSSPMSADRVVSFMDQIRLFQDQVEKLNRLQVDSAEYACLKAIALFTSDACGLTDP
Q6P117_BRARE LFILNAAQSALPLHMAPLLAAAGFHSSPMSAERVVSFMDQVRVFQDQVEKLTRLQVDSAEYSCLKAIALFSPDACGLTDP
Q6P115_BRARE LFILNAAQSALPLHTAPLLAAAGFHSSPMPADRVVSFMDQVRVFQDQVDKLTRLQVDSVEYSCLKAIALFSPDACGLSDP
940 950 1040 1050 1060 1250
===|=========|======== ==|=========|=========|= =====|==
CONSENSUS AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSSFNWPYG
EAR2_HUMAN AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYG !
Q922G8_MOUSE AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYG
EAR2_MOUSE AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISKLFFMRLVGKTPIETLIRDMLLSGSTFNWPYG
EAR2_RAT AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYG
Q6GL59_XENTR AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSSFNWPYS
Q7T0T7_XENLA AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSSFNWPYS
Q6P117_BRARE AHVESLQEKAQVALTEYERMQYPGQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMQLSGSSISWPYA
Q6P115_BRARE AHVESLQEKAQVALTEYERMQYPGQPQRFGRLLLRLPALRAVPANLISQLFFMRLVGKTPIETLIRDMQLSGSSISWPYV
CONSENSUS SGQ
EAR2_HUMAN SGQ.............................................................................
Q922G8_MOUSE SG..............................................................................
EAR2_MOUSE SG..............................................................................
EAR2_RAT SG..............................................................................
Q6GL59_XENTR SGQ.............................................................................
Q7T0T7_XENLA SGQ.............................................................................
Q6P117_BRARE PGQ.............................................................................
Q6P115_BRARE PGQ.............................................................................