2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS FDAALVGHMGPLSPMKPDLKPDISLLNGSNNGPFSPGPASPGPFNQLQQWLNVEAAFMSPMSPPEMKPDTAMLDGGGLRD
Q9GSG7_AEDAE FDAALVGHMGPLSpmKPDLKPDISLLNGSV.GPFSPgpASPGAFNQQ.....VAAALQQQQQNVNSLNSQQSGGGGGGGG
Q9GSG8_AEDAE FDAALVGHMGPVSpmKPDLKPDISLLNGSV.GPFSPgpASPGAFNQQ.....VAAALQQQQQNVNSLNSQQSGGGGGAGG
Q9U3Y3_AEDAL FDAALVGHMGPLSpmKPDLKPDISLLNGSV.GPFscGPASPGAFNQQ.....VAAAPQQQQQNvnSLNSQQQNSGGGGGG
USP_DROME MDNCDQDASFRLSHIKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAG
USP_CHOFU ..........MSSVAKKD.KPTMSVTALIN.gPPQPQSASPAPAAMLqqWLNLEPGFMSPMSPPEMKPDTAMLD..GLRD
USP_MANSE ..........MSSVAKKD.KRTMSVTALIN.wPLTPAppSSQPSNFLqqWLNIEPGFMSPMSPPEMKPDTAMLD..GLRD
USP_BOMMO ..........MSSVAKKD.KRTMSVTALIN..RAWPMTPSPQQQQQmiQWLNIESGFMSPMSPPEMKPDTAMLD..GFRD
Q962I5_LUCCU MDNGEQDAGFRLAPMSPqiKPDISLLNENNTSSYSPKPGSPNPFAIGLQAINAVAAANANNQN.......QMLQ......
Q6IVK1_PLOIN ....................................MEPSRESGLNL.....ENSTFMSPMSPPEMKPDTAMLD..GLRD
Q8I1M8_9NEOP ....................................MEPSREPGLNL......EGSFMSPMSPPEMKPDTAMLD..VLRD
O45117_CHITE IDSSLLGHMGPLSP..PDLKPDISLLNCNN.nTFSPipSSPLSSIGNGSGTIVTFNQIKLQSPSPSNASSSSTLsgNGNC
D010 D020 D030 D040 D050
|=========|=========|=========|=========|=======
CONSENSUS DATPPPMFKQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDRNCIIDKRQRNRCQYCR
Q9GSG7_AEDAE GttPTNMSQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDKNCTIDKRQRNRCQYCR
Q9GSG8_AEDAE GttPTNMSQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDKNCTIDKRQRNRCQYCR
Q9U3Y3_AEDAL GttPTNMSQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDKNCTIDKRQRNRCLYCR
USP_DROME GSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCR
USP_CHOFU DATSPPNFKNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREERNCIIDKRQRNRCQYCR
USP_MANSE DSTPPPAFKNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREDRNCIIDKRQRNRCQYCR
USP_BOMMO DSTPPPPFKNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREDKNCIIDKRQRNRCQYCR
Q962I5_LUCCU ..TTPPQQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREDRNCIIDKRQRNRCQYCR
Q6IVK1_PLOIN DATSPPSFKNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREERNCIIDKRQRNRCQYCR
Q8I1M8_9NEOP DATSPPSFKNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREERNCIIDKRQRNRCQYCR
O45117_CHITE GNTANGKQSQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREERNCVIDKKQRNRCQYCR
D060 140
==|====== ===|===
CONSENSUS YQKCLACGMKREAVQEERQRAARGTEDALAASGGGSGGGGSVGHPSSKFSGGGGGVSIKSEEINGSDDFMSTSSVRDLTI
Q9GSG7_AEDAE YQKCLACGMKREAVQEERQR.........................SSKFS.......IKSEEIN......STSSVRDVTI
Q9GSG8_AEDAE YQKCLACGMKREAVQEERQR.........................SSKFS.......IKSEEIN......STSSVRDVTI
Q9U3Y3_AEDAL YQKCLACGMKREAVQEERQR.........................SSKFS.......IKSEEIN......STSSVRDVTI
USP_DROME YQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSI
USP_CHOFU YQKCLACGMKREAVQEERQRNARGAEDA...............HPSSSVQ.......................VSDELSI
USP_MANSE YQKCLACGMKREAVQEERQRAARGTEDA...............HPSS..........................SVQELSI
USP_BOMMO YQKCLACGMKREAVQEERQRAARRTEDA...............HPSS..........................SVQELSI
Q962I5_LUCCU YQKCLACGMKREAVQEERQRGTRAANARAAGAGGGGGGGGGvfKPSS..........................SLRDLTI
Q6IVK1_PLOIN YQKCLACGMKREAVQEERQRAARGTEDA...............HPSSSVQ......................VSAEELSI
Q8I1M8_9NEOP YQKCLACGMKREAVQEERQRAARGTEDPL...............PSS..........................SVQELSI
O45117_CHITE YQKCLNCGMKREAVQEERQRGGKSQKGDD.............MSISSTQS..................LVNNGPGRDITV
150 330 340 350 450 550
======|====== ==|=========|=========|=== ===|==========|
CONSENSUS ERIHEAEQLSEDKSGDEEIQFLRVGPNSMVPPEYKGAVSHLCQMVNKQIYQLIDFARRIPHFGQLPLDDQVLLLKAGWNE
Q9GSG7_AEDAE ERIHEAEQLSEQKSGDNAIPYLRVGSNSMIPPEYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNE
Q9GSG8_AEDAE ERIHEAEQLSEQKSGDNAIPYLRVGSNSMIPPEYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNE
Q9U3Y3_AEDAL ERITAAEQLSEQKSGDNAIPYLRVGSNSMIPPEYKGAVSHLCQMVNKQIYQLIDFARRLPHFTNLHRDDQVMLLRCGWNE
USP_DROME ERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIE
USP_CHOFU ERLTEMESLVADPS..EEFQFLRVGPDSNVPPRYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELDDQVVLIKASWNE
USP_MANSE ERLLEIESLVADPP..EEFQFLRVGPESGVPAKYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELEDQILLIKNSWNE
USP_BOMMO ERLLELEALVADSA..EELQILRVGPESGVPAKYRAPVSSLCQIGNKQIAALIVWARDIPHFGQLEIDDQILLIKGSWNE
Q962I5_LUCCU ERIIEAEQKAESLSGDNVLPFLRVGNNSMVQHDYKGAVSHLCQMVNKQLYQMVEYARRTPHFTHLQREDQILLLKAGWNE
Q6IVK1_PLOIN ERLLEMEALVADTS..EEFQFLRVGPDSNVPPKFRAPVSSLCQIGNKQIAALVVWARDIPHFSQLELEDQVTLIKASWNE
Q8I1M8_9NEOP ERLLEMESLVADTS..EECQFLRVGPESNVPPKFRAPVSSLCQIGNKQIAALVVWARDIPHFSQLEMDDQVLLIKGAWNE
O45117_CHITE ERLMEADQMSEARCGDKSIQYLRVAA.SniPPEYRAPVSAICAMVNKQVFQHMDFCRRLPHFTKLPLNDQMYLLKQSLNE
560 650 740 750
=========| ===|=== ====|=========|=
CONSENSUS LLIAAVAWRSMEYLEDERAGGAGGGENVDGSFERRSTVRQPQLMCLMPGFTLHRNSAQQAGVDQIFDRILSELSIKMKRL
Q9GSG7_AEDAE MLIAAVAWRSMEYIETER........SSDGS...RITVRQPQLMCLGPNFTLHRNSAQQAGVDTLFDRILCELGIKMKRL
Q9GSG8_AEDAE MLIAAVAWRSMEYIETER........SSDGS...RITVRQPQLMCLGPNFTLHRNSAQQAGVDTLFDRILCELGIKMKRL
Q9U3Y3_AEDAL MLIAAVAWRSMEYIETER........SPDGS...RISIRQPQLMCLGPNFTLHRNSAQQAGVDTLFDRILCELGIKMKRL
USP_DROME LLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRL
USP_CHOFU LLLFAIAWRSMEYLEDER.......ENGDGT...RST.TQPQLMCLMPGMTLHRNSAQQAGVGAIFDRVLSELSLKMRTL
USP_MANSE LLLFAIAWRSMEYLTDER.......ENVD.S...RST.APPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRTL
USP_BOMMO LLLFAIAWRSMEFLNDER.......ENVD.S...RNT.APPQLICLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRSL
Q962I5_LUCCU LLIANVAWCSIESLDAEY...ASPGTVHDGSFGRRSPVRQPQQLFLNQNFSYHRNSAIKANVVSIFDRILSELSIKMKRL
Q6IVK1_PLOIN LLLFAIAWRSMEYLTDER.......DNVDGS...RTT.SPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELALKMRSL
Q8I1M8_9NEOP LLLFAIAWRSMEFLNDER.......ENMDGS...RTT.SPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRHL
O45117_CHITE LLILNIAYMSIQYVEPDR.......RNADGSLERRQI...SQQMCLSRNYTLGRNMAVQAGVVQIFDRILSELSVKMKRL
850 940 950 1040 1050 1060
==|========= ====|=========|======== ==|=========|=========|=
CONSENSUS DMDRAELGALKAIILFNPDIRGLKCRKEIDVLREKIYACLDEHCRQQHPSEDGRFAQLLLRLPALRSISLKCLDHLFFFH
Q9GSG7_AEDAE DVTRAELGVLKAIILFNPDIRGLKCQKEIDGMREKIYACLDEHCKQQHPSEDGRFAQLLLRLPALRSISLKCLDHLNFIR
Q9GSG8_AEDAE DVTRAELGVLKAIILFNPDIRGLKCQKEIDGMREKIYACLDEHCKQQHPSEDGRFAQLLLRLPALRSISLKCLDHLNFIR
Q9U3Y3_AEDAL DVTRAELGVLKAIILFNPDIRGLKCQNGDDGMREKIYACLDEHCKQQHPSEDGRFAQLLLRLPALRSISLKCLDHLNFIR
USP_DROME NLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFR
USP_CHOFU RMDQAEYVALKAIVLLNPDVKGLKNRQEVDVLREKMFSCLDDYCRRSRSNEEGRFASLLLRLPALRSISLKSFEHLYFFH
USP_MANSE RMDQAEYVALKAIILLNPDVKGLKNKPEVVVLREKMFSCLDEYVRRSRCAEEGRFAALLLRLPALRSISLKCFEHLYFFH
USP_BOMMO RMDQAECVALKAIILLNPDVKGLKNKQEVDVLREKMFLCLDEYCRRSRGGEEGRFAALLLRLPALRSISLKSFEHLYLFH
Q962I5_LUCCU NIDRSELSCLKAIILFNPDIRGLKCRADVEVCREKIYACLDEHCRTEHPGDDGRFAQLLLRLPALRSISLKCLDHLFFFR
Q6IVK1_PLOIN PVDQAEYVALKAVILLNPDVKGLNSRQEVEVLREKMYSCLDEYCRRSRGSEEGRFASLLLRLPALRSISLKSFEHLFFFH
Q8I1M8_9NEOP RMDQAEYVALKAIILLNPDIKGLGNRQEVEVLREKMYSCLDEYCRRVRVSEEGRFASLLLRLPALRSISLKSFEHLFFFH
O45117_CHITE DLDATELCLLKSIVVFNPDVRTLDDRKSIDLLRSRIYASLDEYCRQKHPNEDGRFAQLLLRLPALRSISLKCLDHLFYFQ
1250
=====|==
CONSENSUS LVADKSLDSFIIEALRAPPIDTSAMMLE
Q9GSG7_AEDAE LLSDKHLDSFIVEMLDMPI.............................................................
Q9GSG8_AEDAE LLSDKHLDSFIVEMLDMPI.............................................................
Q9U3Y3_AEDAL LLSDKHLDNFIIEMLDMPM.............................................................
USP_DROME ITSDRPLEELFLEQLEAPPPPGLAMKLE.................................................... !
USP_CHOFU LVAEGSISGYIREALraPPIDVNAMM......................................................
USP_MANSE LVADTSIASYIHDALraPSIDTSIL.......................................................
USP_BOMMO LVAEGSVSSYIRDALcaPPIDTNIM.......................................................
Q962I5_LUCCU LIGERALEELIAEQLEAPIC............................................................
Q6IVK1_PLOIN LVADGSIPGYIRDALrkPPLDAsiM.......................................................
Q8I1M8_9NEOP LVADSSIAGYIRDLLraPPIDASALM......................................................
O45117_CHITE LIDDKNVENSVIEEFHKLN.............................................................