NucleaRDB 1I2 Pregnane X (PXR)

The logo  2005, NucleaRDB.
                                                                  D010      D020      D030      D040                                                                                                    
                                                                    |=========|=========|=========|                                                                                                     
CONSENSUS          MEVRPEESWNHADLVECEEEESAPGKPGINADEEDGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR                                                                                                     
PXR_HUMAN          MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
Q9UNW4_HUMAN       LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
Q8SQ01_MACMU       MEVRPKEGWNHADFVYCEDTEFAPGKPTVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
PXR_MOUSE          ..MRPEESWSRVGLVQCEEADSALEEP.INVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFR
PXR_RAT            ..MRPEERWNHVGLVQREEADSVLEEP.INVDEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFR
Q9TU02_RABIT       ......................MGGKPTISADEEEG.PQTCRVCGDKANGYHFNVLTCEGCKGFFRRTVKRNARLRCPFR
Q91839_XENLA       ....MWKVQETLVLEEEEEEEDASNSCGTGEDEDDGDPKICRACGDRATGYHFNAMTCEGCKGFFRRAVKRNLRLSCPF.
Q8AVZ2_XENLA       ....MWKVQETLVLEEEEEEEDASNSCGTGEDEDDGDPKICRACGDRATGYHFNAMTCEGCKGFFRRAMKRNLRLSCPF.
Q9DF24_XENLA       ...MSEVQEAVVLEEEEEEEEDPCNSCGTGEDEDDGEPKICRACGDRATGYHFNAMTCEGCKGFFRRAMKRNLRLSCPF.
                          D050      D060                                             140       150                                                                                                      
                   =========|=========|=======                                     ===|=========|==                                                                                                     
CONSENSUS          KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAQPPGGQGLTEEQQMMIRELMDAQMK                                                                                                     
PXR_HUMAN          KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK
Q9UNW4_HUMAN       KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK
Q8SQ01_MACMU       KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEERRALIKRKKRERIGTQPPGVQGLTEEQRMMIRELMDAQMK
PXR_MOUSE          KGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQ
PXR_RAT            KGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQ
Q9TU02_RABIT       KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDVAVAQRRALIKRKKRERMEAQPPGMQGLTGEQRMIIEELMDAQMK
Q91839_XENLA       QNSCVINKSNRRHCQACRLKKCLDIGMRKELIMSDAAVEQRRALIKRkkLTKLPPTPPG.ASLTPEQQHFLTQLVGAHTK
Q8AVZ2_XENLA       QNSCVINKSNRRHCQACRLKKCLDIGMRKELIMSDAAVEQRRALIKRkkLTKSPPTPPG.ASLTPEQQHFLTQLVGAHTK
Q9DF24_XENLA       QNSCVINKNNRRHCQACRLKKCLDIGMRKELIMSDEAVEQRRALIKRKQNLSLSPPTPPGASLTPEQQHFITELVEAHTK
                                                                                               330                                                                                                      
                   ====                                                                       ==|==                                                                                                     
CONSENSUS          TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQIRKDLCSMKVSLQLRGEDGSVWNYKPPADSSGKEIFSLL                                                                                                     
PXR_HUMAN          TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Q9UNW4_HUMAN       TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Q8SQ01_MACMU       TFDTTFSHFKNFRLPGVLSSGCEMPESLQAPSREEAAKWNQVRKDLWSVKVSVQLRGEDGSVWNYKPPADNGGKEIFSLL
PXR_MOUSE          TFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLL
PXR_RAT            TFDTTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGSIWNYQPPSKSDGKEIIPLL
Q9TU02_RABIT       TFDTTFSHFKNFRLPEVLGSGCEIPESLQALTEEEAGRWRQIQEELGTMKLSLQLRGEDGSVWNYTPPADRSGKKLFSLL
Q91839_XENLA       TFDFNFTFSKNFR..........................................PIRRSSDPTQEPQATSS..EAFLML
Q8AVZ2_XENLA       TFDFNFTFSKNFR..........................................PIRRSSDPTQEPQATSS..EAFLML
Q9DF24_XENLA       TFDFNFTFFKNFR..........................................PIRRSPDPTQDPQATSS..EAFLML
                         340       350          450        550       560                                                                                                                                
                   =======|=========|===      ===|==========|=========|                        ====                                                                                                     
CONSENSUS          PHLADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDPAGGFQQLLL                                                                                                     
PXR_HUMAN          PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLL
Q9UNW4_HUMAN       PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLL
Q8SQ01_MACMU       PHMADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATFELCQLRFNTVFNAETGTWECGRLSYCLEDPAGGFQQLLL
PXR_MOUSE          PHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLL
PXR_RAT            PHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLL
Q9TU02_RABIT       PHLADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATLELCLLRFNTVFNAETGTWECGRLSYCVEDPEGGFQQLLV
Q91839_XENLA       PHISDLVTYMIKGIISFAKMLPYFKSLDIEDQIALLKGSVAEVSVIRFNTVFNSDTNTWECGPFTYDTEdfLAGFRQLFL
Q8AVZ2_XENLA       PHISDLVTYMIKGIISFAKMLPYFKSLDIEDQIALLKGSVAEVSVIRFNTVFNPDTNTWECGPFTYDTEdfLAGFRQLFL
Q9DF24_XENLA       PHISDLFTYMLKGVISFAKMLPYFRSLAIEDQIALLKGSVLEVCVIRFNRMFNPKTNTWECGAFTYNADdtMAGFSQQFL
                  740      750      850                     940       950             1040      1050                                                                                                    
                   |========|=     ==|=========          ====|=========|========      ==|=========|                                                                                                     
CONSENSUS          EPLLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVVQHEVVDQLQEQFAITLKAYIECNRPQPAHRFLFLKIMAMLTEL                                                                                                     
PXR_HUMAN          EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL
Q9UNW4_HUMAN       EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL
Q8SQ01_MACMU       EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVVQHRVVDQLQEQYAITLKSYIECNRPQPAHRFLFLKIMAMLTEL
PXR_MOUSE          DPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTEL
PXR_RAT            DPLMKFHCMLKKLQLREEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTEL
Q9TU02_RABIT       DPLLKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQREVVDQLQERFAITLKAYIECSRPQPTHRFLFLKIMAVLTEL
Q91839_XENLA       EPLVRIHRMMRKLNLQSEEYAMMAALSIFASDRPGVCDWEKIQKLQEHIALTLKDFIDSQRpsPQNRLLYPKIMECLTEL
Q8AVZ2_XENLA       EPLVRIHRMMRKLNLQSEEYAMMAALSIFASDRPGVCDWEKIQKLQEHIALTLKDFIDSQRpsLQNRLLYPKIMECLTEL
Q9DF24_XENLA       EPLLRIHCMMTKLNLESEAYALMATMALFSSDRPGVSDCEKIQNLQEHIALMLKAFIESHRpsPQNRLLYPKIMECLTEL
                          1060             1250                                                                                                                                                         
                   =========|=          =====|==                                                                                                                                                        
CONSENSUS          RSINAQHTQQLLRIQDIHPFATPLMQELFGSTDS                                                                                                                                                   
PXR_HUMAN          RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS..............................................
Q9UNW4_HUMAN       RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS..............................................
Q8SQ01_MACMU       RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS..............................................
PXR_MOUSE          RSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG..............................................
PXR_RAT            RSINAQQTQQLLRIQDTHPFATPLMQELFSSTDG..............................................
Q9TU02_RABIT       RTINAQHTQRLLRIQDTHPFATPLMRELFSTTDD..............................................
Q91839_XENLA       RTVNDIHSKQLLEIWDIQPDATPLMREVFGSPE...............................................
Q8AVZ2_XENLA       RTVNDIHSKQLLEIWDIQPDATPLMREVFGSPE...............................................
Q9DF24_XENLA       RTINDIHSKQLMEIWDIQPDVTPLMREVFGSLNE..............................................

The top layer shows the consensus sequence. Residues are coloured after their physico-chemical properties. (GPX black; positive blue; negative red; CM yellow; H dark purple; NQ light purple; all others green).


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