2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
D010 D020 D030 D040
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CONSENSUS MEVRPEESWNHADLVECEEEESAPGKPGINADEEDGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
PXR_HUMAN MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR !
Q9UNW4_HUMAN LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
Q8SQ01_MACMU MEVRPKEGWNHADFVYCEDTEFAPGKPTVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR
PXR_MOUSE ..MRPEESWSRVGLVQCEEADSALEEP.INVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFR
PXR_RAT ..MRPEERWNHVGLVQREEADSVLEEP.INVDEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFR
Q9TU02_RABIT ......................MGGKPTISADEEEG.PQTCRVCGDKANGYHFNVLTCEGCKGFFRRTVKRNARLRCPFR
Q91839_XENLA ....MWKVQETLVLEEEEEEEDASNSCGTGEDEDDGDPKICRACGDRATGYHFNAMTCEGCKGFFRRAVKRNLRLSCPF.
Q8AVZ2_XENLA ....MWKVQETLVLEEEEEEEDASNSCGTGEDEDDGDPKICRACGDRATGYHFNAMTCEGCKGFFRRAMKRNLRLSCPF.
Q9DF24_XENLA ...MSEVQEAVVLEEEEEEEEDPCNSCGTGEDEDDGEPKICRACGDRATGYHFNAMTCEGCKGFFRRAMKRNLRLSCPF.
D050 D060 140 150
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CONSENSUS KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAQPPGGQGLTEEQQMMIRELMDAQMK
PXR_HUMAN KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK !
Q9UNW4_HUMAN KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK
Q8SQ01_MACMU KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEERRALIKRKKRERIGTQPPGVQGLTEEQRMMIRELMDAQMK
PXR_MOUSE KGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQ
PXR_RAT KGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQ
Q9TU02_RABIT KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDVAVAQRRALIKRKKRERMEAQPPGMQGLTGEQRMIIEELMDAQMK
Q91839_XENLA QNSCVINKSNRRHCQACRLKKCLDIGMRKELIMSDAAVEQRRALIKRkkLTKLPPTPPG.ASLTPEQQHFLTQLVGAHTK
Q8AVZ2_XENLA QNSCVINKSNRRHCQACRLKKCLDIGMRKELIMSDAAVEQRRALIKRkkLTKSPPTPPG.ASLTPEQQHFLTQLVGAHTK
Q9DF24_XENLA QNSCVINKNNRRHCQACRLKKCLDIGMRKELIMSDEAVEQRRALIKRKQNLSLSPPTPPGASLTPEQQHFITELVEAHTK
330
==== ==|==
CONSENSUS TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQIRKDLCSMKVSLQLRGEDGSVWNYKPPADSSGKEIFSLL
PXR_HUMAN TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL !
Q9UNW4_HUMAN TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Q8SQ01_MACMU TFDTTFSHFKNFRLPGVLSSGCEMPESLQAPSREEAAKWNQVRKDLWSVKVSVQLRGEDGSVWNYKPPADNGGKEIFSLL
PXR_MOUSE TFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLL
PXR_RAT TFDTTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGSIWNYQPPSKSDGKEIIPLL
Q9TU02_RABIT TFDTTFSHFKNFRLPEVLGSGCEIPESLQALTEEEAGRWRQIQEELGTMKLSLQLRGEDGSVWNYTPPADRSGKKLFSLL
Q91839_XENLA TFDFNFTFSKNFR..........................................PIRRSSDPTQEPQATSS..EAFLML
Q8AVZ2_XENLA TFDFNFTFSKNFR..........................................PIRRSSDPTQEPQATSS..EAFLML
Q9DF24_XENLA TFDFNFTFFKNFR..........................................PIRRSPDPTQDPQATSS..EAFLML
340 350 450 550 560
=======|=========|=== ===|==========|=========| ====
CONSENSUS PHLADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDPAGGFQQLLL
PXR_HUMAN PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLL !
Q9UNW4_HUMAN PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLL
Q8SQ01_MACMU PHMADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATFELCQLRFNTVFNAETGTWECGRLSYCLEDPAGGFQQLLL
PXR_MOUSE PHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLL
PXR_RAT PHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLL !
Q9TU02_RABIT PHLADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATLELCLLRFNTVFNAETGTWECGRLSYCVEDPEGGFQQLLV
Q91839_XENLA PHISDLVTYMIKGIISFAKMLPYFKSLDIEDQIALLKGSVAEVSVIRFNTVFNSDTNTWECGPFTYDTEdfLAGFRQLFL
Q8AVZ2_XENLA PHISDLVTYMIKGIISFAKMLPYFKSLDIEDQIALLKGSVAEVSVIRFNTVFNPDTNTWECGPFTYDTEdfLAGFRQLFL
Q9DF24_XENLA PHISDLFTYMLKGVISFAKMLPYFRSLAIEDQIALLKGSVLEVCVIRFNRMFNPKTNTWECGAFTYNADdtMAGFSQQFL
740 750 850 940 950 1040 1050
|========|= ==|========= ====|=========|======== ==|=========|
CONSENSUS EPLLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVVQHEVVDQLQEQFAITLKAYIECNRPQPAHRFLFLKIMAMLTEL
PXR_HUMAN EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL !
Q9UNW4_HUMAN EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL
Q8SQ01_MACMU EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVVQHRVVDQLQEQYAITLKSYIECNRPQPAHRFLFLKIMAMLTEL
PXR_MOUSE DPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTEL
PXR_RAT DPLMKFHCMLKKLQLREEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTEL !
Q9TU02_RABIT DPLLKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQREVVDQLQERFAITLKAYIECSRPQPTHRFLFLKIMAVLTEL
Q91839_XENLA EPLVRIHRMMRKLNLQSEEYAMMAALSIFASDRPGVCDWEKIQKLQEHIALTLKDFIDSQRpsPQNRLLYPKIMECLTEL
Q8AVZ2_XENLA EPLVRIHRMMRKLNLQSEEYAMMAALSIFASDRPGVCDWEKIQKLQEHIALTLKDFIDSQRpsLQNRLLYPKIMECLTEL
Q9DF24_XENLA EPLLRIHCMMTKLNLESEAYALMATMALFSSDRPGVSDCEKIQNLQEHIALMLKAFIESHRpsPQNRLLYPKIMECLTEL
1060 1250
=========|= =====|==
CONSENSUS RSINAQHTQQLLRIQDIHPFATPLMQELFGSTDS
PXR_HUMAN RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS.............................................. !
Q9UNW4_HUMAN RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS..............................................
Q8SQ01_MACMU RSINAQHTQRLLRIQDIHPFATPLMQELFGITGS..............................................
PXR_MOUSE RSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG.............................................. !
PXR_RAT RSINAQQTQQLLRIQDTHPFATPLMQELFSSTDG..............................................
Q9TU02_RABIT RTINAQHTQRLLRIQDTHPFATPLMRELFSTTDD..............................................
Q91839_XENLA RTVNDIHSKQLLEIWDIQPDATPLMREVFGSPE...............................................
Q8AVZ2_XENLA RTVNDIHSKQLLEIWDIQPDATPLMREVFGSPE...............................................
Q9DF24_XENLA RTINDIHSKQLMEIWDIQPDVTPLMREVFGSLNE..............................................