2005, NucleaRDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
D010 D020 D030 D040 D050
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CONSENSUS MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
VDR_HUMAN MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR !
VDR_SAGOE MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
VDR_BOVIN ...MAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
VDR_RAT MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
VDR_MOUSE MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
Q922X0_MOUSE MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
VDR_CHICK MDTVAASTSLPDpgDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFNGDCKITKDNRRHCQACR
VDR_COTJA METPAVGTP.....EFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFSGDCKITKDNRRHCQACR
Q5R8V3_PONPY MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACR
Q9IB73_PAROL MEPMTVTTSMVGPDEFDRNAPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACR
VDR_XENLA MEFMAATTSIADTdeFDKNVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFNGDCRITKDNRRHCQSCR
Q9PTN2_BRARE MDLMAVSTSATGQDQFDRNAPPICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACR
Q9IB74_PAROL MEPTVVSTSSLASDEFDRNMPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKATFTCPFNGSCTITKDNRRHCQACR
Q7ZZY9_PETMA MMamTVSTSNALEDDEEGGVPKVCGVCGDKATGYHFNAMTCEGCKGFFRRSMKRSASFTCPFEGKCNITKDNRRHCQACR
D060 140 150
==|====== ===|=========|======
CONSENSUS LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLRPKLSEEQQRIIAILLEAHHKTYDPTYSDFCQFRPPVREN
VDR_HUMAN LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVN !
VDR_SAGOE LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVN
VDR_BOVIN LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVN
VDR_RAT LKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMD
VDR_MOUSE LKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRAD
Q922X0_MOUSE LKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRAD
VDR_CHICK LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVIDTLLEAHHKTFDTTYSDFNKFRPPVRSK
VDR_COTJA LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVINILLEAHHKTFDTTYSDFNKFRPPVRSK
Q5R8V3_PONPY LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVN
Q9IB73_PAROL LKRCIDIGMMKEFILTDEEVQREKEMILKRKEEEAAREAMRPRLNEEQARMISSLVEAHHKTYDASYSDFSRFRPPVREG
VDR_XENLA LKRCVDIGMMKEFILTDEEVQRKRQMINKRKSEEALKESMRPKISDEQQKMIDILLEAHRKTFDTTYSDFNKFRPPVREN
Q9PTN2_BRARE LKRCIDIGMMKEFILTDEEVQRKKDLIMKRKEEEAAREARKPRLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVREG
Q9IB74_PAROL LKRCVDIGMMREFILTDEEVQRKKDLIQRRKDEEAQREAerPRLTDEQSQVIAMLVEAHHKTYDDSYSDFCRFRPPVREG
Q7ZZY9_PETMA LKRCRDIGMMKELIMTEEEVQRKKEIIMKRKLEDSAREVHTPQLLEEQERLIATLIEAHRKTYDASYSDFSQFRPPKR..
330 340
==|=========|=====
CONSENSUS DSTGSAPSRPSSRSTPSFSGDSSSSCSDHYTTSPDMMEPSSFSNLDLSEEDSDDPSVTLELSPLSMLPHLADLVSYSIQK
VDR_HUMAN DGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK !
VDR_SAGOE DGGGSHPSRPNSRHTPSFSGDSSSCCSDHYITSPDMMDSSSFSNLDLSEEDSDDPSLTLELSQLSMLPHLADLVSYSIQK
VDR_BOVIN DGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VDR_RAT GSTGSY....SPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQK
VDR_MOUSE VSTGSY....SPRPTLSFSGDSSS.NSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQK
Q922X0_MOUSE VSTGSY....SPRPTLSFSGDSSS.NSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQK
VDR_CHICK FSSRMATHSSSVVSQDFSSEDSNDvgSDAFAAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQK
VDR_COTJA FSSSTATHSSSVVSQDFSSEDSNDvgSDAFGAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQK
Q5R8V3_PONPY DGGGSHPSRPNSRHTPSFSGDSSSSCSDNCITSPDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
Q9IB73_PAROL PVTRSASRAASLHSLSDASSDSF......NHSPESVDTKMNFSNLLMMYQdaSSPDSSEENTKLSMLPHLADLVSYSIQK
VDR_XENLA VDPFRRITRSSSVHTqsPSEDS.....DVFTSSPDSSEHGFFSalFGQFEYS...SMGGKSGELSMLPHIADLVSYSIQK
Q9PTN2_BRARE PVTRSASRAASLHSLSDASSDSF......NHSPESVDTKLNFSNLLMMYQDSGSpsEEDQQSRLSMLPHLADLVSYSIQK
Q9IB74_PAROL PVTRSASRAASLHSLSDASSDSFS......HSPESVDTKVNFNNLLMmeQGSSPDSSEEEGSSFSMLPHLADLVSYSIQK
Q7ZZY9_PETMA ...................GDGSPEC..RNATNPFLM.SLLNSDMDELPKASASGAEAAAGDELSMLPHLADLVSYSIQK
350 450 550 560 650 740 750
====|=== ===|==========|=========| ===|=== ====|========|
CONSENSUS VIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMDDMSWTCGSQDFKYRISDVTKAGHTLELLEPLVKFQVGL
VDR_HUMAN VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGL !
VDR_SAGOE VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNPDYKYRISDVTKAGHNLELIEPLIKFQVGL
VDR_BOVIN VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGL
VDR_RAT VIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGL
VDR_MOUSE VIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGL
Q922X0_MOUSE VIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGL
VDR_CHICK VIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGL
VDR_COTJA VIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGL
Q5R8V3_PONPY VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRISDVTKAGHSLELIEPLIKFQVGL
Q9IB73_PAROL VIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGL
VDR_XENLA IIGFAKMIPGFRDLIAEDQIALLKSSVIEVIMLRSNQSFSLDDMSWTCGSEDFKYKVDDVTQAGHNMELLEPLVKFQVGL
Q9PTN2_BRARE VIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGL
Q9IB74_PAROL VIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFNLEDMSWSCGAPDFKYQISDVTKAGHTLELLEPLVKFQVGL
Q7ZZY9_PETMA VIGFAKMIPGFKELCTEDQISLLKASAIEIIILRSNESFTMEDNSWTCGSNEFKYQIGDVMQAGHKLELLEPLVKFQVNM
850 940 950 1040 1050 1060
= ==|========= ====|=========|======== ==|=========|=========|
CONSENSUS KKLNLHEEEHVLLMAICIVSPDRPGVQDAALVEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ
VDR_HUMAN KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ !
VDR_SAGOE KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ
VDR_BOVIN KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ
VDR_RAT KKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQ
VDR_MOUSE KKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQ !
Q922X0_MOUSE KKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQ
VDR_CHICK KKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDILQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQ
VDR_COTJA KKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDTLQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQ
Q5R8V3_PONPY KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYA...................
Q9IB73_PAROL KKLNLHEEEHVLLMGICLLSPDRPGVQDHARVEQLQDRLPEALQAYIRINHP..GGRLLYAKMIQKLADLRSLNEEHSKQ
VDR_XENLA KKLDLHEEEHVLLMAICILSPDRPGLQDKALVESIQDRLSSTLQTYILCKHPPPGSRLLYAKMIQKLADLRSLNEEHSKQ
Q9PTN2_BRARE KKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHP..GGRLLYAKMIQKLADLRSLNEEHSKQ
Q9IB74_PAROL KKLNLQEEEHVMLMAICLLSPDRPGVQDHARIEALQDRLSETLQAYIQLHHP..GGRLLYAKMIQKLADLRSLNEEHSKQ
Q7ZZY9_PETMA KKLDLHEAEHVLLMAICLFSPDRPGVQDRCRVEEVQEHLTETLRAYIACRHPLSCKHMLYTKMVEKLTELRSLNEEHSKQ
1250
= =====|==
CONSENSUS YRSLSFQPEHSMKLTPLVLEVFGNEIS
VDR_HUMAN YRCLSFQPECSMKLTPLVLEVFGNEIS..................................................... !
VDR_SAGOE YRCLSFQPESSMKLTPLVLEVFGNEIS.....................................................
VDR_BOVIN YRCLSFQPECSMKLTPLVLEVFGNEIS.....................................................
VDR_RAT YRSLSFQPENSMKLTPLVLEVFGNEIS.....................................................
VDR_MOUSE YRSLSFQPENSMKLTPLVLEVFGNEIS.....................................................
Q922X0_MOUSE YRSLSFQPENSMKLTPLVLEVFGNEIS.....................................................
VDR_CHICK YRCLSFQPEHSMQLTPLVLEVFGNEIS.....................................................
VDR_COTJA YRCLSFQPEHSMQLTPLVLEVFGNEIS.....................................................
Q5R8V3_PONPY ................................................................................
Q9IB73_PAROL YRSLSFQPEHSMQLTPLVLEVFGSEVS.....................................................
VDR_XENLA YRSISFLPEHSMKLTPLMLEVFSDEIP.....................................................
Q9PTN2_BRARE YRSLSFQPEHSMQLTPLVLEVFGSEVS.....................................................
Q9IB74_PAROL YRSLSFRPEHSMQLTPLVLEVSGSEVS.....................................................
Q7ZZY9_PETMA YLQISQDAVNKEDLPPLLLEVFGNPTA.....................................................