NucleaRDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in ANDR_HUMAN at position 81 were found are listed after the table.

Point mutations at position S81 in ANDR_HUMAN

ProteinANDR_HUMAN (P10275)    Gene: AR,DHTR, NR3C    (other point mutations)Swiss-Prot
Cross-reference table
Family page
PositionS81
General numbering (NucleaRDB) -
DomainN-term
Family alignments 3C4 Androgen (AR)
3C Glucocorticoid-like (GR,MR,PR,AR)
3 Estrogen like (ER,ERR,GR,MR,PR,AR)
Other point mutations at the same position Position 62 in 3C4 Androgen (AR) family
Position 25 in 3C Glucocorticoid-like (GR,MR,PR,AR) family
Reference #1Gioeli D, Ficarro SB, Kwiek JJ, Aaronson D, Hancock M, Catling AD, White FM, Christian RE, Settlage RE, Shabanowitz J, Hunt DF, Weber MJ
J Biol Chem 2002 Aug 9;277(32):29304-14.		Medline
Text sourceHTML and PDF full texts
Point mutationS81A (True positive)
Point mutationS81D (True positive)
Reference #2Fu M, Rao M, Wu K, Wang C, Zhang X, Hessien M, Yeung YG, Gioeli D, Weber MJ, Pestell RG
J Biol Chem 2004 Jul 9;279(28):29436-49. Epub 2004 Apr 30.		Medline
Text sourceHTML full text
Point mutationS81A (Not yet checked)

Relevant sentences

Reference #1 (Gioeli D et al.): S81A
  • The QuikChange TM site-directed mutagenesis kit (Stratagene) was used to make the single mutants S81A , S256A , S81D , S308D , and S650D and the double mutants S81A / S650A and S81 / 650D

  • Moreover , the double mutants , S81A / S650S or S81D / S650D also had no effect on AR transcription

Reference #2 (Fu M et al.): S81A
  • The ARwt and point mutants of the AR phosphorylation site (AR S81A , AR S94A , AR S256A , AR S308A , AR S426A , and AR S650A) were described elsewhere (23 )

Reference #1 (Gioeli D et al.): S81D
  • The QuikChange TM site-directed mutagenesis kit (Stratagene) was used to make the single mutants S81A , S256A , S81D , S308D , and S650D and the double mutants S81A / S650A and S81 / 650D

  • Moreover , the double mutants , S81A / S650S or S81D / S650D also had no effect on AR transcription

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F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005