NucleaRDB: Point mutations extracted from the literature - PXR_RAT

2005, NucleaRDB.

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Protein	PXR_RAT (Nr1i2,Px)	Swiss-Prot Cross-reference table Family page
Family alignments	1I2 Pregnane X (PXR) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR

Mutation Location General numbering Reference
F305L Loop 5-7 Tirona RG et al., Mol Pharmacol 2004 Medline

K314Q LBD HELIX 7 736 Tirona RG et al., Mol Pharmacol 2004 Medline

M321L LBD HELIX 7 743 Tirona RG et al., Mol Pharmacol 2004 Medline

C325Y LBD HELIX 7 747 Tirona RG et al., Mol Pharmacol 2004 Medline

Mutation	Location	General numbering	Reference
F305L	Loop 5-7		Tirona RG et al., Mol Pharmacol 2004	Medline
K314Q	LBD HELIX 7	736	Tirona RG et al., Mol Pharmacol 2004	Medline
M321L	LBD HELIX 7	743	Tirona RG et al., Mol Pharmacol 2004	Medline
C325Y	LBD HELIX 7	747	Tirona RG et al., Mol Pharmacol 2004	Medline

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005