NucleaRDB: Point mutations extracted from the literature - PXR_HUMAN

2005, NucleaRDB.

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Protein	PXR_HUMAN (NR1I2,PX)	Swiss-Prot Cross-reference table Family page
Protein isoforms	6
Family alignments	1I2 Pregnane X (PXR) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR

Mutation Location General numbering Reference
E18K N-term Hustert E et al., Drug Metab Dispos 2001 Medline

P27S N-term Hustert E et al., Drug Metab Dispos 2001 Medline

G36R N-term Hustert E et al., Drug Metab Dispos 2001 Medline

V140M HINGE Hustert E et al., Drug Metab Dispos 2001 Medline

D163G LBD HELIX 1 155 Hustert E et al., Drug Metab Dispos 2001 Medline

D205A Loop 1-3 Hustert E et al., Drug Metab Dispos 2001 Medline

F288A LBD HELIX 5 556 Watkins RE et al., Biochemistry 2003 Medline

W299M Loop 5-7 Watkins RE et al., Biochemistry 2003 Medline

L308F Loop 5-7 Tirona RG et al., Mol Pharmacol 2004 Medline

A370T LBD HELIX 9 947 Hustert E et al., Drug Metab Dispos 2001 Medline

H407A LBD HELIX 10-11 1057 Ostberg T et al., Eur J Biochem 2002 Medline

H407Q LBD HELIX 10-11 1057 Watkins RE et al., Biochemistry 2003 Medline

Mutation	Location	General numbering	Reference
E18K	N-term		Hustert E et al., Drug Metab Dispos 2001	Medline
P27S	N-term		Hustert E et al., Drug Metab Dispos 2001	Medline
G36R	N-term		Hustert E et al., Drug Metab Dispos 2001	Medline
V140M	HINGE		Hustert E et al., Drug Metab Dispos 2001	Medline
D163G	LBD HELIX 1	155	Hustert E et al., Drug Metab Dispos 2001	Medline
D205A	Loop 1-3		Hustert E et al., Drug Metab Dispos 2001	Medline
F288A	LBD HELIX 5	556	Watkins RE et al., Biochemistry 2003	Medline
W299M	Loop 5-7		Watkins RE et al., Biochemistry 2003	Medline
L308F	Loop 5-7		Tirona RG et al., Mol Pharmacol 2004	Medline
A370T	LBD HELIX 9	947	Hustert E et al., Drug Metab Dispos 2001	Medline
H407A	LBD HELIX 10-11	1057	Ostberg T et al., Eur J Biochem 2002	Medline
H407Q	LBD HELIX 10-11	1057	Watkins RE et al., Biochemistry 2003	Medline

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005