NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation L121A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation L121A in ANDR_HUMAN

Point mutation:	L121A
Domain:	N-term
General numbering (NucleaRDB):	-
Protein:	ANDR_HUMAN (AR,DHTR, NR3C)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in ANDR_HUMAN
Family alignments	3C4 Androgen (AR) 3C Glucocorticoid-like (GR,MR,PR,AR) 3 Estrogen like (ER,ERR,GR,MR,PR,AR)
Other point mutations / same position
Reference:	Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation. Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ J Biol Chem 2004 May 21;279(21):21766-73. Epub 2004 Mar 18.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

L121A

Tip110 mutants ; {Delta}NR deleted for the NR box , L118A (leucine at position 118 mutated to alanine) , L121A (leucine at position 121 mutated to alanine) , and L122A (leucine at position 122 mutated to alanine) ; were constructed similarly in the context of the pTip110.His backbone using the ExSite PCR-based site-directed mutagenesis kit (Stratagene , La Jolla , CA)
The oligonucleotides for each mutant are: {Delta}NR , 5'-GTC CAC ATG GCA GTT GTA GTC ATA-3' and 5-AGG CTC GAG GGG GAG CTT ACC AAG GTG-3' ; L118A , 5'-CAG GTG TAC CGT CAA CAT CAG TAT CTG C-3' and 5'-CGG CTA GTC TGA CGA GTC CGA CCT TCC CC-3' ; L121A , 5'-AGA CTA GTT CAG GTG TAC CGT CAA CAT C-3' and 5'-CGG GAG TCC GAC CTT CCC CTC GAA TGG-3' ; L122A , 5'-GTC AGA CTA GTT CAG GTG TAC CGT C-3' and 5'-CGG TCC GAC CTT CCC CTC GAA TGG TTC C-3'
L118A , L121A , and L122A are Tip110 containing an amino acid change from leucine to alanine at positions 118 , 121 , and 122 , respectively

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005