NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation N222K was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation N222K in ANDR_HUMAN

Point mutation:	N222K
Domain:	N-term
General numbering (NucleaRDB):	-
Protein:	ANDR_HUMAN (AR,DHTR, NR3C)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in ANDR_HUMAN
Family alignments	3C4 Androgen (AR) 3C Glucocorticoid-like (GR,MR,PR,AR) 3 Estrogen like (ER,ERR,GR,MR,PR,AR)
Other point mutations / same position	Position 169 in 3C Glucocorticoid-like (GR,MR,PR,AR) family
Reference:	Role of conserved hydrophobic amino acids in androgen receptor AF-1 function. Betney R, McEwan IJ J Mol Endocrinol 2003 Dec;31(3):427-39.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

N222K

None of the mutations described are within the highly conserved region studied in the present paper , but reporter gene activity is available for two of the mutations , G214R and N222K (residues 213 and 221 relative to AR4 numbering) , which exhibited 80% and 46% transactivation activity respectively (Wang et al. 1998 , Lundberg-Giwercman et al. 2001)

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005