NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation Y401A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation Y401A in VDR_HUMAN

Point mutation:	Y401A
Domain:	LBD HELIX 10-11
General numbering (NucleaRDB):	1061
Protein:	VDR_HUMAN (VDR,NR1I)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in VDR_HUMAN
Family alignments	1I1 Vitamin D3 (VDR) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position
Reference:	Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity. Verlinden L, Verstuyf A, Verboven C, Eelen G, De Ranter C, Gao LJ, Chen YJ, Murad I, Choi M, Yamamoto K, Yamada S, Van Haver D, Vandewalle M, De Clercq PJ, Bouillon R J Biol Chem 2003 Sep 12;278(37):35476-82. Epub 2003 Jun 26.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

Y401A

pCMX-expression vectors encoding wild type VDR and 12 different VDR point mutants (L233A , V234A , I268A , I271A , R274A , S275A , S278A , W286A , V300A , H305A , H397A , and Y401A) were used in transfection experiments (16 )
1 , 25(OH)2D3 was unable to transactivate when cells were transfected with mutated VDRs carrying either the L233A , I271A , R274A , W286A , H397A , or Y401A mutation (Fig. 6 )
Much like 1 , 25(OH)2D3 , 19-nor-TD-vitamin D could not transactivate in cells transfected with the VDR mutants L233A , I271A , R274A , W286A , H397A , or Y401A

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005