NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation Q380A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation Q380A in VDR_MOUSE

Point mutation:	Q380A
Domain:	LBD HELIX 10-11
General numbering (NucleaRDB):	1045
Protein:	VDR_MOUSE (Vdr,Nr1i)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 380 in VDR_MOUSE
Other point mutations / same protein	List of mutations in VDR_MOUSE
Family alignments	1I1 Vitamin D3 (VDR) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 385 in 1I1 Vitamin D3 (VDR) family Position 380 in 1I Vitamin D3-like (VDR,PXR,CAR) family Position 369 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues. Barry JB, Leong GM, Church WB, Issa LL, Eisman JA, Gardiner EM J Biol Chem 2003 Mar 7;278(10):8224-8.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

Q380A

Mutant Delta 389 was further mutated to create Delta 389Q380E , Delta 389D384K , Delta 389R386E , and Delta 389AX3 , the last being a triple point mutant with coordinate Q380A , D384A , and R386A changes
Mutant 389 was further mutated to create 389Q380E , 389D384K , 389R386E , and 389AX3 , the last being a triple point mutant with coordinate Q380A , D384A , and R386A changes

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005