NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation F27A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation F27A in ANDR_HUMAN

Point mutation:	F27A
Domain:	N-term
General numbering (NucleaRDB):	-
Protein:	ANDR_HUMAN (AR,DHTR, NR3C)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in ANDR_HUMAN
Family alignments	3C4 Androgen (AR) 3C Glucocorticoid-like (GR,MR,PR,AR) 3 Estrogen like (ER,ERR,GR,MR,PR,AR)
Other point mutations / same position
Reference:	The FXXLF motif mediates androgen receptor-specific interactions with coregulators. He B, Minges JT, Lee LW, Wilson EM J Biol Chem 2002 Mar 22;277(12):10226-35.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

F27A

AR-FXXAA (pCMVhAR-L26A / F27A) had 23FQNLF27 changed to 23FQNAA27 , and AR-FXXAA / WXXAA (pCMVhAR-L26A / F27A / L436A / F437A) had the additional mutation of 433WHTLF437 changed to 433WHTAA437 (18 , 19 )
pCMVhARDelta 142-337 and pCMVhARDelta 142-337L26A / F27A (ARDelta 142-337FXXAA) have the AF1 region deleted in the NH2-terminal domain (19 , 28 )
The latter AR mutant lacks the NH2-terminal AF1 residues 142-337 and has the NH2-terminal FXXLF motif mutated to FXXAA (L26A / F27A) (Fig. 7 C)
pCMVhAR 142 337 and pCMVhAR 142337L26A / F27A (AR 142337FXXAA) have the AF1 region deleted in the NH2-terminal domain (19 , 28)

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005