Results of Nuclear Localization Signal Prediction(NLS):

  • Help on interpretation of results.


    • Input Sequence (NLS's in Red) 
    MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSCCSDHYITSPDMMDSSSFSNLDLSEEDSDDPSLTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNPDYKYRISDV
TKAGHNLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPESSMKLTPLVLE
VFGNEIS
    Sequence Length427
    NLS's found. No gives position of Motif
    • RRSMKRK 48
    • RRSMKRK 48
    • RRSMKRK 48
    • RRSMKRK 48

    Statistical data for Nuclear Localization Signals present in the Input Sequence

    Generalized NLS
    ( notation )    		 TypeNo with NLS%Nuc Proteins%NonNuc ProteinsProtein Swiss IdProtein Localizations(Swiss anno.)
    RR[TS]x[QK][KR][KN] Potential 35 100 0 vdr_bovin nuc
    tha_chick nuc
    thb_chick nuc
    vdr_chick nuc
    vdr_cotja nuc
    dnl4_human nuc
    rrb2_human nuc
    rrg1_human nuc
    rrg2_human nuc
    tha1_human nuc
    tha2_human nuc
    thb1_human nuc
    thb2_human nuc
    vdr_human nuc
    rra_mouse nuc
    rrb_mouse nuc
    rrg1_mouse nuc
    rrg2_mouse nuc
    tha1_mouse nuc
    tha2_mouse nuc
    vdr_mouse nuc
    rra_notvi nuc
    rrb_notvi nuc
    tha2_rat nuc
    tha_ranca nuc
    thb_ranca nuc
    vdr_rat nuc
    tha1_sheep nuc
    thb1_sheep nuc
    rra_xenla nuc
    rrg1_xenla nuc
    rrg2_xenla nuc
    thaa_xenla nuc
    thab_xenla nuc
    vdr_xenla nuc
    RRxxKRK Potential 25 100 0 h2b_acrfo nuc
    vdr_bovin nuc
    vdr_chick nuc
    vdr_cotja nuc
    elf1_drome nuc
    t2fa_drome nuc
    twst_drome nuc
    dnl4_human nuc
    ets1_human nuc
    ets2_human nuc
    moz_human nuc
    rag1_human nuc
    vdr_human nuc
    ve2_hpv48 nuc
    ets2_lytva nuc
    ets1_mouse nuc
    ets2_mouse nuc
    vdr_mouse nuc
    ets1_rat nuc
    vdr_rat nuc
    et1a_xenla nuc
    et1b_xenla nuc
    et2a_xenla nuc
    et2b_xenla nuc
    vdr_xenla nuc
    RR[TS]x[QK][KR][KNS] Potential 41 100 0 vdr_bovin nuc
    tha_chick nuc
    thb_chick nuc
    vdr_chick nuc
    vdr_cotja nuc
    dnl4_human nuc
    rrb2_human nuc
    rrg1_human nuc
    rrg2_human nuc
    tha1_human nuc
    tha2_human nuc
    thb1_human nuc
    thb2_human nuc
    vdr_human nuc
    hmgt_mouse nuc
    rra_mouse nuc
    rrb_mouse nuc
    rrg1_mouse nuc
    rrg2_mouse nuc
    tha1_mouse nuc
    tha2_mouse nuc
    thb1_mouse nuc
    thb2_mouse nuc
    vdr_mouse nuc
    rra_notvi nuc
    rrb_notvi nuc
    tha2_rat nuc
    tha_ranca nuc
    thb1_rat nuc
    thb2_rat nuc
    thb_ranca nuc
    vdr_rat nuc
    h1s_strpu nuc
    tha1_sheep nuc
    thb1_sheep nuc
    rra_xenla nuc
    rrg1_xenla nuc
    rrg2_xenla nuc
    thaa_xenla nuc
    thab_xenla nuc
    vdr_xenla nuc
    RRSMKRK Experimental 7 100 0 vdr_bovin nuc
    vdr_chick nuc
    vdr_cotja nuc
    vdr_human nuc
    vdr_mouse nuc
    vdr_rat nuc
    vdr_xenla nuc

    This protein is predicted to bind to DNA.

    DNA Binding signals. RR[TS]x[QK][KR][KN]

    DNA binding statistics for the binding NLS signals.

    DnaBindNLS No binding DNA %binding DNA No in binding Domain %in binding Domain % of associated DNA binding domains
    RR[TS]x[QK][KR][KN] 34 97.14 34 100 ZINC FINGERS: 100

    Symbols used in representing the NLS are explained below:

    An x (or X) implies any amino acid residue can be present at this position.

    Example Motifs
    Example Read Equivalent Motifs
    [KR]KRKK "K or R" KRKK KKRKK,RKRKK
    K{5} 5 times K KKKKK
    [KR]{3,5} between 3 and 5 times K or R KKRR, RRKKR, RRR,KKK ...
    K{3,}? 3 or more K's KKK,KKKK,KKKKK ...