Results of Nuclear Localization Signal Prediction(NLS):

  • Help on interpretation of results.


    • Input Sequence (NLS's in Red) 
    MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMGPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
    Sequence Length777
    NLS's found. No gives position of Motif
    • DKIRRKN 465
    • DKIRRKN 465
    • RKCLQAGMNLEARKTKK 478
    • RKCLQAGMNLEARKTKK 478

    Statistical data for Nuclear Localization Signals present in the Input Sequence

    Generalized NLS
    ( notation )    		 TypeNo with NLS%Nuc Proteins%NonNuc ProteinsProtein Swiss IdProtein Localizations(Swiss anno.)
    RKCLQAGMNLEARKTKK Experimental 8 100 0 gcr_aotna nuc
    gcr_human nuc
    gcr_mouse nuc
    gcr_rat nuc
    gcr_sagoe nuc
    gcr_saibb nuc
    gcr_tupgb nuc
    gcr_xenla nuc
    RKx{7,12}RK[STMNQ]KK Potential 16 100 0 gcr_aotna nuc
    gcr_cavpo nuc
    aant_hdvit nuc
    aant_hdvl1 nuc
    aant_hdvna nuc
    aant_hdvwo nuc
    gcr_human nuc
    gcr_mouse nuc
    gcr_oncmy nuc
    gcr_parol nuc
    gcr_rat nuc
    gcr_sagoe nuc
    gcr_saibb nuc
    gcr_tupgb nuc
    gcr_xenla nuc
    rox1_yeast nuc
    [DE]K[NIF]RR[DEK][STMNQ] Potential 24 100 0 gcr_aotna nuc
    gcr_cavpo nuc
    prgr_chick nuc
    andr_human nuc
    gcr_human nuc
    mcr_human nuc
    prgr_human nuc
    andr_mouse nuc
    gcr_mouse nuc
    prgr_mouse nuc
    gcr_oncmy nuc
    gcr_parol nuc
    andr_rabit nuc
    andr_rat nuc
    gcr_rat nuc
    mcr_rat nuc
    prgr_rabit nuc
    gcr_sagoe nuc
    gcr_saibb nuc
    prgr_sheep nuc
    gcr_tupgb nuc
    mcr_tupgb nuc
    gcr_xenla nuc
    mcr_xenla nuc
    [DE]KxRRK[MNQ] Potential 23 100 0 gcr_aotna nuc
    prgr_chick nuc
    andr_human nuc
    gcr_human nuc
    mcr_human nuc
    prgr_human nuc
    andr_mouse nuc
    gcr_mouse nuc
    prgr_mouse nuc
    gcr_oncmy nuc
    gcr_parol nuc
    andr_rabit nuc
    andr_rat nuc
    gcr_rat nuc
    mcr_rat nuc
    prgr_rabit nuc
    gcr_sagoe nuc
    gcr_saibb nuc
    prgr_sheep nuc
    gcr_tupgb nuc
    mcr_tupgb nuc
    gcr_xenla nuc
    mcr_xenla nuc

    This protein is predicted to bind to DNA.

    DNA Binding signals. RKx{7,12}RK[STMNQ]KK [DE]KxRRK[MNQ] [DE]K[NIF]RR[DEK][STMNQ]

    DNA binding statistics for the binding NLS signals.

    DnaBindNLS No binding DNA %binding DNA No in binding Domain %in binding Domain % of associated DNA binding domains
    RKx{7,12}RK[STMNQ]KK 12 75 12 100 ZINC FINGERS: 91.66HMG BOX: 8.33
    [DE]KxRRK[MNQ] 23 100 23 100 ZINC FINGERS: 100
    [DE]K[NIF]RR[DEK][STMNQ] 24 100 24 100 ZINC FINGERS: 100

    Symbols used in representing the NLS are explained below:

    An x (or X) implies any amino acid residue can be present at this position.

    Example Motifs
    Example Read Equivalent Motifs
    [KR]KRKK "K or R" KRKK KKRKK,RKRKK
    K{5} 5 times K KKKKK
    [KR]{3,5} between 3 and 5 times K or R KKRR, RRKKR, RRR,KKK ...
    K{3,}? 3 or more K's KKK,KKKK,KKKKK ...