KChannelDB: Pairwise Alignments

logo    2003, KChannelDB.


The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-1-20c $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       HCN4_RAT
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      AF247453
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 2956.13 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

HCN4_RAT           1 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIR 
                     MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIR 
                     MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIR 
AF247453         228 agaccctacacctaccccgggagtaagggggggggggggccgcacaaac 
                     taatccctgagtagtcaatgcacgttaaaaagaaagcggtaacggggtg 
                     gcggggcgcggccctgggggcgggcgcgagttgaggcgccgcacagctg 


HCN4_RAT          50 LRPLPSPSPSVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRG 
                     LRPLPSPSPSVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRG 
                     LRPLPSPSPSVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRG 
AF247453         375 ccccctctctggggttgtcgggcggggaggcgcaggataaaggtactcg 
                     tgctcccccctccggcacggcctgccagagcgggcgacgcagagggtgg 
                     ggggcgcgcggcccccgcgtgccggaccgggcccccgcccctccgcccg 


HCN4_RAT          99 SLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPP 
                     SLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPP 
                     SLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPP 
AF247453         522 acgtcgacgggaggggggaacgcccgtgggcccaggggggtcgggaacc 
                     gtcctgggggggggcgggggtgataaccaaggttccagacccgaagccc 
                     tgcggccgcccttaagccctcgcgtccgggggccctgctgcccgcggcg 


HCN4_RAT         148 GLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAA 
                     GLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAA 
                     GLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAA 
AF247453         669 gcgagcgccggggccggtcccccccccgtgttgcctggagaaggggggg 
                     gtccacagcgcccacccccccaaccacccccgaacccacctataggccc 
                     cggcgcgcgccgaacacgggcagggggcccccggcggcatcagaacgcc 


HCN4_RAT         197 SDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQE 
                     SDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQE 
                     SDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQE 
AF247453         816 agcaccggggccgcagtaccctggacccggaattcaatgacagggcgcg 
                     gaattcacatgtgaggttagatgcttacgtaatctgttggaactagaaa 
                     ccgcctgcggcgcgcccggcgctcggatgccacgaggcccgaaggtggg 


HCN4_RAT         246 RVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 
                     RVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 
                     RVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 
AF247453         963 agatggttaacctagtatttgcaactcaggacaaacggaattaggaaac 
                     gtaccgtgttacagatgtagatcttttttgattttctgtcttaaaaccc 
                     gtgatgtgtcccccccatcgcgggggggggtgccctgcccccgtgcccc 


HCN4_RAT         295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFV 
                     WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFV 
                     WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFV 
AF247453        1110 tagtaggtgattcagtgcatcagaggggaagaacgcccaaaatcaattg 
                     gtttattcacttttatttatgcgtttaaacatttacagtataataggtt 
                     gccccggacaccctcgcccccggcgggccaacctcaggcgggcgacgtg 


HCN4_RAT         344 VDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLS 
                     VDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLS 
                     VDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLS 
AF247453        1257 ggtattacggtatcaggacagtggtaagagccagctaaacaccccccct 
                     tattcctctaatttttacgtacataaccgctgttgtcattgttgttgtc 
                     gcccccccgcccctaggtctcggccaccgtgctcccggccccgccggtc 


HCN4_RAT         393 RLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPM 
                     RLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPM 
                     RLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPM 
AF247453        1404 ccactacctggatcaatgcgagggcagacagaaccctctggtcctcgca 
                     gttgataagaattatcaatcgcttgttattgtttttgagaggtatttct 
                     cctgctcggagcccgcccgctcgaccgcctcggtgtccgtccggcggcg 


HCN4_RAT         442 LQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMS 
                     LQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMS 
                     LQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMS 
AF247453        1551 ccgtccgttgtaagagaattgactttgctagaacactagtgccgcggat 
                     taatcaaggtctagttaacggaaacacttactgattgtgaggacctgtc 
                     ggccctccggccccggtccggggcctcccgcgccggttgcaggacacgt 


HCN4_RAT         491 DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMS 
                     DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMS 
                     DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMS 
AF247453        1698 ggtcaacaaagggattgatagcgagcactcgttccctcgatacggctat 
                     atgtcttgtttgccgactttgacccttactaccggaaaaaaaataaatc 
                     ccgccgccgcgcccctcgccgcctcccgggcccgcgcgggcgggggcgc 


HCN4_RAT         540 FHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRK 
                     FHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRK 
                     FHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRK 
AF247453        1845 tcacccgaaccacgttgcctcgaatgggaacggcagcccggaaatatca 
                     taatccacgagtaaaaaagaagattaaagttgatgactgaattatagga 
                     ccgcgtccggccccccacccgcggtcgaccgtggtggtaggccctccgg 


HCN4_RAT         589 LVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQH 
                     LVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQH 
                     LVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQH 
AF247453        1992 cggtacctgaggcatgatacaatctggtccggtaacggaagaaattacc 
                     ttcctcttcacacattccttcatgtattacgaattgagctgaatattaa 
                     ggacgagcctaccctggtggcggttgctgtgcccctaccccgggctcgc 


HCN4_RAT         638 GVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSV 
                     GVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSV 
                     GVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSV 
AF247453        2139 gggagcaagaagaacgggtttggattcacgccagagaggattccttcag 
                     gttgttcagaaacatcagcatgatgttcggggccgtgcacaggtactgt 
                     cgctgctgccggcggttccttagccggcactcagcgggttcccccagcg 


HCN4_RAT         687 DNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFN 
                     DNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFN 
                     DNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFN 
AF247453        2286 gataggcggtcaacagtgaggcgccgcagaaatacccagccgcatggta 
                     aataattaaacttggctactctagtagtgaaactttaataaatacgtta 
                     ccccgggggtcggcgtcggtggctgccacggccccccgggccccacccc 


HCN4_RAT         736 YQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQA 
                     YQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQA 
                     YQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQA 
AF247453        2433 tcgagaaccagccgcgagctgccgcgggtgacacacgataccacgcccg 
                     aaaaattaattgaagatcagcagtacccccccccccttgccttacctac 
                     cagcgccggcggtctggccttcccgttcaccacagtcagcagcgaaggt 


HCN4_RAT         785 AAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLI 
                     AAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLI 
                     AAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLI 
AF247453        2580 gggaatggagcaccccccggatccccgcgcgacgggcacaccaatctta 
                     cccccctctctcaacgtcccttgcccgcgtgatgcgaccgacggtactt 
                     tttttggcaccaccccgactccgctcatggtcggtagaggcaggggcgc 


HCN4_RAT         834 PSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSP 
                     PSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSP 
                     PSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSP 
AF247453        2727 ctgcgtgtcgaactcggactttttcacccggttgccgtacctcttattc 
                     ccctgcccccggccatacccccctataatcgtccccgtgcttcccgccc 
                     tagacttaaccccaggcagtatccccaggtactattagttcgcctctca 


HCN4_RAT         883 PPGACSSPPAPTPSTSTAATTTGFGHFHKALGGSLSSSDSPLLTPLQPG 
                     PPGACSSPPAPTPSTSTAATTTGFGHFHKALGGSLSSSDSPLLTPLQPG 
                     PPGACSSPPAPTPSTSTAATTTGFGHFHKALGGSLSSSDSPLLTPLQPG 
AF247453        2874 ccggtatccgcactataggaaagtgctcagcggtctttgtcccaccccg 
                     ccgcggccccccccccccccccgtgataactggctcccaccttcctacg 
                     taaccttcacctacccttccccgcccttggatccgtcttcggccagagc 


HCN4_RAT         932 ARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGE 
                     ARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGE 
                     ARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGE 
AF247453        3021 gctccggcccccccggcggcgccgcttccccttctcttacgccgcccgg 
                     cgccaccacccctcgcgggtgttaattccccccgccccgcgatgaccga 
                     tctagtcggacagtgcaacgacggccggcatgcgaaatctgggcgttag 


HCN4_RAT         981 LSPGLAAGPPSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHS 
                     LSPGLAAGPPSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHS 
                     LSPGLAAGPPSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHS 
AF247453        3168 ttcgcgggccaacgaccccgccttagggtgggtcggtaccggcaccgca 
                     tccgtccgccgccacccgcagccttcgccggccctctccgggtgccgag 
                     gcatgattaataagacggcagactgagctggtttactccaaccctgccc 


HCN4_RAT        1030 PGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT 
                     PGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT 
                     PGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT 
AF247453        3315 cgccaatcagcccgtgtcgtcccccgtacccccgcccagacccacgcca 
                     cgccgctcgcccgccgcagctttccccgccccatcagggccctccggtc 
                     aacaatcgtcacgctccttcgcgatacctgtcgcagcgcaaccccccca 


HCN4_RAT        1079 QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSGSS 
                     QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSGSS 
                     QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSGSS 
AF247453        3462 cgcacatgtccgcccgggcaccagtccttggtaggttctcaggggagaa 
                     aatattcccacctcaagcactggcccaccgactcctctacgcggggggg 
                     gcggccactgacccgtgagtacgcttccaggggtccacccatgtctgct 


HCN4_RAT        1128 GGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLT 
                     GGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLT 
                     GGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLT 
AF247453        3609 ggcgccgactggacgccgatccaattgttcccctttggaggttggccca 
                     ggtgccggcagctcgaatctcgacccgctccctcttgcgccccggcctc 
                     gctgttagattccacgtctgtggacattgacattgtgaaccttagctgt 


HCN4_RAT        1177 AAPQREPGARSEPVRSKLPSNL                            
                     AAPQREPGARSEPVRSKLPSNL                            
                     AAPQREPGARSEPVRSKLPSNL                            
AF247453        3756 ggccagcggatgcgctacctat                            
                     cccagacgcgcactgcatccat                            
                     tacggatctgcgaaccaggtta                            


//


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F.Horn (nucleardbcmbi.ru.nl), 24-Jul-2003