KChannelDB: Pairwise Alignments

logo    2003, KChannelDB.


The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-1-20c $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       HCN3_HUMAN
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      BC000066
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 1414.71 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

HCN3_HUMAN       204 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 
                     AR LRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 
                     ARGLRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 
BC000066           2 gcgccagctaaacaccacccctccactacctggatcaatgcgagggcat 
                     cggtgttgtcattgttgttgtcgttgataagaattatcaatcgcttgtt 
                     aacacctcccgcacggggcccccccccacggggctcgctcgcttgtccc 


HCN3_HUMAN       253 NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHA 
                     NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHA 
                     NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHA 
BC000066         149 acagaaccctctggtcctcgcaccgtccgttgtaacagacttgccttcg 
                     attgtttttgagaggtatttcttaatccaggtctaattaacgggaacac 
                     cctgggggatcgtctggcggcgggcctcccgcccccggccggccgtctc 


HCN3_HUMAN       302 LFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALI 
                     LFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALI 
                     LFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALI 
BC000066         296 ctagaacactagtgccgcggacggtcaacaaagggattgatagcgagca 
                     ttactgattgtgagaacctgtcatgtcttgtttgccgactttgaccctt 
                     gcgcgccggctctgggatacgcccgccgccgcatcacccgccctcgacc 


HCN3_HUMAN       351 QSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDE 
                     QSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDE 
                     QSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDE 
BC000066         443 ctcgttccctcgatacggctattcaccggacccacgttgcctcgaatgg 
                     actaccggaaaaaaaataaatctaatccacgagtaaaaaagaagattaa 
                     gcgctcgtgcgggcgggggcgcccggaacgggcccgctgcccgcggctg 


HCN3_HUMAN       400 ESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEV 
                     ESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEV 
                     ESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEV 
BC000066         590 gaacggcagcccggaaatatcgcggcacctgcggcatgaggcaacctgg 
                     agttgatgactgaattatcgggttcatcttcacacgttccttcatgtat 
                     accgcggcggtcggctccctgcggccgggtctcccccctatccgtctgc 


HCN3_HUMAN       449 FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLL 
                     FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLL 
                     FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLL 
BC000066         737 tccggcggcggtggaaattaccgccagcgcggcgaccaggtttggatcc 
                     tacgatttgagctggatattaagttgttcggcgacgtcagcatgatgtt 
                     cgggtcggtgccgggggcccgtggctggccccgcaccctacctggccga 


HCN3_HUMAN       498 TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLR 
                     TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLR 
                     TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLR 
BC000066         884 aagccagagcggattccttcaggctaggcggtcaaccgtgaggagcccc 
                     cggggccgtgcacaggtactgtaatacttaatcttggctactctagttg 
                     tgcgcacttgtccccctcaccgctcttgtggccggcgctgtgcgtggcc 


HCN3_HUMAN       547 IGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQ 
                     IGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQ 
                     IGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQ 
BC000066        1031 agaaatacccactgcacgaaggaagcctgccgagagcggcgcgcaaggc 
                     tgaaacttagagcacgcgggggttaaattaaagatcggtgggccgcgca 
                     ccggtcaggggccgataccttccgggcggatcacgtgttgtgcgcaatg 


HCN3_HUMAN       596 LSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLAR 
                     LSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLAR 
                     LSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLAR 
BC000066        1178 cagacgctgccgcgcccggggataggagcacccgcccctcgtcgaccgc 
                     tggacttgacttacctaccctccatctctcaaggctctccaccccttcg 
                     ttagaagggagatgctgattgcctgctcgttggctgccctctacccttc 


HCN3_HUMAN       645 SAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSL 
                     SAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSL 
                     SAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSL 
BC000066        1325 tgtctggtcgtccgcgcggctgtatcccgccgcaccgactcggctcgtc 
                     ccggccgcccccttctgcgcgccccgtcccccgctacgtcgcggcatct 
                     ttgcaactatcgggccatcagaccccgccatcacgcccacgagccgccg 


HCN3_HUMAN       694 LGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPS 
                     LGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPS 
                     LGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPS 
BC000066        1472 cgcccggggcccgccgccctgtcctccccgagggtcgcagtgagcccct 
                     tgcccggggggtgcgggctcccacctcagccgagccggagcggagtccc 
                     gtctaaataggaatgccacaccactgtggaactcttgtgaaatgggtca 


HCN3_HUMAN       743 GLLAKPPRTAQPPRPPVPEPATPRGLQLSANM                  
                     GLLAKPPRTAQPPRPPVPEPATPRGLQLSANM                  
                     GLLAKPPRTAQPPRPPVPEPATPRGLQLSANM                  
BC000066        1619 gccgaccaagcccaccgcgcgaccgccctgaa                  
                     gttcaccgccaccgcctcaccccggtatccat                  
                     gcgcatagacgccgaagtgacacgtcgttccg                  


//


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F.Horn (nucleardbcmbi.ru.nl), 24-Jul-2003