Swiss-Prot entry
ID TOK1_YEAST STANDARD; PRT; 691 AA.
AC P40310; Q05721;
DT 01-FEB-1995 (Rel. 31, Created)
DT 01-FEB-1995 (Rel. 31, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Outward-rectifier potassium channel TOK1 (Two-domain outward rectifier
DE K(+) channel YORK).
GN Name=TOK1; Synonyms=DUK1; OrderedLocusNames=YJL093C; ORFNames=J0911;
OS Saccharomyces cerevisiae (Baker's yeast).
OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=4932;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION.
RC STRAIN=NY13;
RX MEDLINE=95379951; PubMed=7651518 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/376690a0;
RA Ketchum K.A., Joiner W.J., Sellers A.J., Kaczmarek L.K.,
RA Goldstein S.A.N.;
RT "A new family of outwardly rectifying potassium channel proteins with
RT two pore domains in tandem.";
RL Nature 376:690-695(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=96303826; PubMed=8723646 [NCBI, ExPASy, EBI, Israel, Japan];
RA Reid J.D., Lukas W., Shafaatian R., Bertl A., Scheurmann-Kettner C.,
RA Guy H.R., North R.A.;
RT "The S. cerevisiae outwardly-rectifying potassium channel (DUK1)
RT identifies a new family of channels with duplicated pore domains.";
RL Recept. Channels 4:51-62(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=96223992; PubMed=8626760 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1074/jbc.271.8.4183;
RA Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G.,
RA Barhanin J.;
RT "A pH-sensitive yeast outward rectifier K+ channel with two pore
RT domains and novel gating properties.";
RL J. Biol. Chem. 271:4183-4187(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S288c;
RX MEDLINE=95076716; PubMed=7985424 [NCBI, ExPASy, EBI, Israel, Japan];
RA Miosga T., Witzel A., Zimmermann F.K.;
RT "Sequence and function analysis of a 9.46 kb fragment of Saccharomyces
RT cerevisiae chromosome X.";
RL Yeast 10:965-973(1994).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / FY1679;
RX MEDLINE=96208490; PubMed=8641269 [NCBI, ExPASy, EBI, Israel, Japan];
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N.,
RA Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H.,
RA Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A.,
RA Hennemann A., Herbert C.J., Heumann K., Hilger F., Hollenberg C.P.,
RA Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L.,
RA Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V.,
RA Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M.,
RA Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W.,
RA Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M.,
RA Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A.,
RA Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M.,
RA Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT X.";
RL EMBO J. 15:2031-2049(1996).
CC -!- FUNCTION: Outwardly rectifying potassium channel.
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel
CC (TC 1.A.1.8) family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
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DR EMBL; U28005; AAC49070.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X94403; CAA64176.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; U37254; AAC49168.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; X77087; CAA54360.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; Z49368; CAA89386.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S46585; S46585.
DR GermOnline; 141707; -.
DR Ensembl; YJL093C; Saccharomyces_cerevisiae
DR SGD; S000003629; TOK1.
DR GO; GO:0005886; C:plasma membrane; IDA.
DR GO; GO:0005267; F:potassium channel activity; IDA.
DR GO; GO:0030007; P:potassium ion homeostasis; IDA.
DR InterPro; IPR003280; K+channel_2pore.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; Graphical view of domain structure.
DR PRINTS; PR01333; 2POREKCHANEL.
DR CMR; P40310.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR BLOCKS; P40310.
DR ProtoNet; P40310.
DR ProtoMap; P40310.
DR PRESAGE; P40310.
DR DIP; P40310.
DR ModBase; P40310.
DR GeneCensus; YJL093C.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Complete proteome; Ion transport; Ionic channel; Transmembrane;
KW Transport; Voltage-gated channel.
FT TRANSMEM 72 92 S1 (Potential).
FT TRANSMEM 138 158 S2 (Potential).
FT TRANSMEM 171 191 S3 (Potential).
FT TRANSMEM 204 224 S4 (Potential).
FT TRANSMEM 247 266 S5 (Potential).
FT TRANSMEM 302 322 S6 (Potential).
FT TRANSMEM 380 400 S7 (Potential).
FT TRANSMEM 436 456 S8 (Potential).
FT CONFLICT 442 442 A -> T (in Ref. 2).
FT CONFLICT 512 512 E -> G (in Ref. 2).
SQ SEQUENCE 691 AA; 77408 MW; 507167E487B77AAF CRC64;
MTRFMNSFAK QTLGYGNMAT VEQESSAQAV DSHSNNTPKQ AKGVLAEELK DALRFRDERV
SIINAEPSST LFVFWFVVSC YFPVITACLG PVANTISIAC VVEKWRSLKN NSVVTNPRSN
DTDVLMNQVK TVFDPPGIFA VNIISLVLGF TSNIILMLHF SKKLTYLKSQ LINITGWTIA
GGMLLVDVIV CSLNDMPSIY SKTIGFWFAC ISSGLYLVCT IILTIHFIGY KLGKYPPTFN
LLPNERSIMA YTVLLSLWLI WGAGMFSGLL HITYGNALYF CTVSLLTVGL GDILPKSVGA
KIMVLIFSLS GVVLMGLIVF MTRSIIQKSS GPIFFFHRVE KGRSKSWKHY MDSSKNLSER
EAFDLMKCIR QTASRKQHWF SLSVTIAIFM AFWLLGALVF KFAENWSYFN CIYFCFLCLL
TIGYGDYAPR TGAGRAFFVI WALGAVPLMG AILSTVGDLL FDISTSLDIK IGESFNNKVK
SIVFNGRQRA LSFMVNTGEI FEESDTADGD LEENTTSSQS SQISEFNDNN SEENDSGVTS
PPASLQESFS SLSKASSPEG ILPLEYVSSA EYALQDSGTC NLRNLQELLK AVKKLHRICL
ADKDYTLSFS DWSYIHKLHL RNITDIEEYT RGPEFWISPD TPLKFPLNEP HFAFMMLFKN
IEELVGNLVE DEELYKVISK RKFLGEHRKT L
//