Swiss-Prot entry

ID   Q9ESM5_RAT  PRELIMINARY;      PRT;   392 AA.
AC   Q9ESM5;
DT   01-MAR-2001 (TrEMBLrel. 16, Created)
DT   01-MAR-2001 (TrEMBLrel. 16, Last sequence update)
DT   01-JUN-2003 (TrEMBLrel. 24, Last annotation update)
DE   TASK1 splice bvariant (TASK1b).
GN   Name=KCNK3b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   Ohya S., Kitsukawa M., Imaizumi Y.;
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: pH-dependent, voltage-insensitive, background potassium
CC       channel protein. Rectification direction results from potassium
CC       ion concentration on either side of the membrane. Acts as an
CC       outward rectifier when external potassium concentration is low.
CC       When external potassium concentration is high, current is inward
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel
CC       (TC 1.A.1.8) family.
DR   EMBL; AB048823; BAB16710.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GO; GO:0016021; C:integral to membrane; IEA.
DR   GO; GO:0005267; F:potassium channel activity; IEA.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA.
DR   GO; GO:0006811; P:ion transport; IEA.
DR   GO; GO:0006813; P:potassium ion transport; IEA.
DR   InterPro; IPR005821; Ion_trans.
DR   InterPro; IPR003280; K+channel_2pore.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR005406; TASK1_channel.
DR   InterPro; IPR003092; TASK_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01584; TASK1CHANNEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   CMR; Q9ESM5.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q9ESM5.
DR   PRESAGE; Q9ESM5.
DR   ModBase; Q9ESM5.
DR   SMR; Q9ESM5.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Ion transport; Ionic channel; Potassium; Potassium channel;
KW   Transmembrane; Transport; Voltage-gated channel.
SQ   SEQUENCE   392 AA;  43150 MW;  F5438B12AAD7FB1B CRC64;
     MKRQNVRTLA LIVCTFTYLL ESELRQLELR ARYNLSEGGY EELERVVLRL KPHKAGVQWR
     FAGSFYFAIT VITTIGYGHA APSTDGGKVF CMFYALLGIP LTLVMFQSLG ERINTFVRYL
     LHRAKRGLGM RHAEVSMANM VLIGFVSCIS TLCIGAAAFS YYERWTFFQA YYYCFITLTT
     IGFGDYVALQ KDQALQTQPQ YVAFSFVYIL TGLTVIGAFL NLVVLRFMTM NAEDEKRDAE
     HRALLTHNGQ AGGLGGLSCL SGSLGDGVRP RDPVTCAAAA GGMGVGVGVG GSGFRNVYAE
     MLHFQSMCSC LWYKSREKLQ YSIPMIIPRD LSTSDTCVEH SHSSPGGGGR YSDTPSHPCL
     CSGTQRSAIS SVSTGLHSLA TFRGLMKRRS SV
//