Swiss-Prot entry

ID   Q8AXC9_RANCA PRELIMINARY;      PRT;   390 AA.
AC   Q8AXC9;
DT   01-MAR-2003 (TrEMBLrel. 23, Created)
DT   01-MAR-2003 (TrEMBLrel. 23, Last sequence update)
DT   01-JUN-2003 (TrEMBLrel. 24, Last annotation update)
DE   ATP sensitive potassium channel kir 6.2.
OS   Rana catesbeiana (Bull frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana. 
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Park P.J., Chung J.Y., Kim S.K.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This receptor is controled by G proteins. Inward
CC       rectifier potassium channels are characterized by a greater
CC       tendancy to allow potassium to flow into the cell rather than out
CC       of it. Their voltage dependence is regulated by the concentration
CC       of extracellular potassium; as external potassium is raised, the
CC       voltage range of the channel opening shifts to more positive
CC       voltages. The inward rectification is mainly due to the blockage
CC       of outward current by internal magnesium. Can be blocked by
CC       extracellular barium (By similarity).
CC   -!- SUBUNIT: Associates with SUR (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       family.
DR   EMBL; AF454384; AAN76866.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P35562; 1N9P. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   GO; GO:0016021; C:integral to membrane; IEA.
DR   GO; GO:0015272; F:ATP-activated inward rectifier potassium ch...; IEA.
DR   GO; GO:0005267; F:potassium channel activity; IEA.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA.
DR   GO; GO:0006811; P:ion transport; IEA.
DR   GO; GO:0006813; P:potassium ion transport; IEA.
DR   InterPro; IPR001838; K+channel_IR.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR003279; KIR62_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01332; KIR62CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   ProDom; PD001103; K+channel_IR; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q8AXC9.
DR   PRESAGE; Q8AXC9.
DR   ModBase; Q8AXC9.
DR   SMR; Q8AXC9.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Ion transport; Ionic channel; Potassium; Potassium transport;
KW   Transmembrane; Transport; Voltage-gated channel.
SQ   SEQUENCE   390 AA;  43461 MW;  E08E910D1020415B CRC64;
     MLSRKGIIPE EYVLTRLAED PAEPRYRARE RRARFVSKKG NRNVAHKNIR EQGRFLQDVF
     TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL APGEGAAVPC VTSIHSFSSA
     FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET
     LIFSKHAVIA LRQGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM
     ENGVGGNSIF LVAPLIIHHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
     RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGDTVKVP TPLCTARQLD EDRSLLDALT
     LTSARGPLRK RSVAVAKAKP KFSISPDSLS
//