Swiss-Prot entry

ID   Q6PCJ5_XENLA PRELIMINARY;      PRT;   369 AA.
AC   Q6PCJ5;
DT   05-JUL-2004 (TrEMBLrel. 27, Created)
DT   05-JUL-2004 (TrEMBLrel. 27, Last sequence update)
DT   05-JUL-2004 (TrEMBLrel. 27, Last annotation update)
DE   Kcnj1 protein.
GN   Name=Kcnj1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Embryo;
RX   MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Embryo;
RX   MEDLINE=22341132; PubMed=12454917 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Embryo;
RA   Klein S., Strausberg R.;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inward rectifier potassium channels are characterized by
CC       a greater tendancy to allow potassium to flow into the cell rather
CC       than out of it. Their voltage dependence is regulated by the
CC       concentration of extracellular potassium; as external potassium is
CC       raised, the voltage range of the channel opening shifts to more
CC       positive voltages. The inward rectification is mainly due to the
CC       blockage of outward current by internal magnesium (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       family.
DR   EMBL; BC059301; AAH59301.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GO; GO:0016021; C:integral to membrane; IEA.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA.
DR   GO; GO:0005267; F:potassium channel activity; IEA.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA.
DR   GO; GO:0006811; P:ion transport; IEA.
DR   GO; GO:0006813; P:potassium ion transport; IEA.
DR   InterPro; IPR001838; K+channel_IR.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR003270; KIR13_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01323; KIR13CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   ProDom; PD001103; K+channel_IR; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q6PCJ5.
DR   PRESAGE; Q6PCJ5.
DR   ModBase; Q6PCJ5.
DR   SMR; Q6PCJ5.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Ion transport; Ionic channel; Potassium; Potassium transport;
KW   Transmembrane; Transport; Voltage-gated channel.
SQ   SEQUENCE   369 AA;  42407 MW;  B827FC86085E06E4 CRC64;
     MDAGHSDLSS CPLVLDDIHV EGKPERPRVI SKSGHSNVKI DKVEGVFLLY LQDLWTTVID
     MKWRYKLTLF AATFFLTWCF FGVIYFVIAF FHGDMNIEPM SNHTPCVMNV DSFTGAFLFS
     MESQTTIGYG FRFITEECPH AIFMLVAQLV LTTLIEIFIT GTFLAKIARP KKRAETIKFS
     NKAVIAKHND KLCLVVQVAN MRKSLLIQCQ LYGKLLHSYE TKEGEKILLQ QANMNFNVDS
     SSESPFLILP LTFYHVLDEK SPLKDLTVDN IKTKDFELVV LLNATVESTS TVCQSRTSYL
     PDEIYWGYEF VPVVSLSSQG KYVADFSNFD KIRKCKAIET IYLAHFEKHK LEEKYRKQEL
     MDRERQTNV
//